Skip to main content
Top
Published in: European Child & Adolescent Psychiatry 2/2010

01-02-2010 | Original Contribution

Does ADHD moderate the manifestation of anxiety disorders in children?

Authors: Paul Hammerness, Daniel Geller, Carter Petty, Alexis Lamb, Elyssa Bristol, Joseph Biederman

Published in: European Child & Adolescent Psychiatry | Issue 2/2010

Login to get access

Abstract

The main aim of this study was to examine the moderating effects of attention deficit hyperactivity disorder (ADHD) on anxiety disorders in children. Data were analyzed from a large referred sample of children with anxiety disorder without comorbid ADHD (anxiety disorder, N = 253), anxiety disorder plus comorbid ADHD (anxiety disorder + ADHD, N = 704), and ADHD without comorbid anxiety disorder (ADHD, N = 511). Children were comprehensively assessed, including by structured diagnostic interview (K-SADS-E). Overall rates of individual anxiety disorders, as well as age of onset and severity of illness were not significantly different in the presence of comorbid ADHD. School functioning in children with anxiety disorders was negatively impacted by the presence of comorbid ADHD. Frequency of mental health treatment in children with anxiety disorders was significantly increased in the presence of comorbid ADHD. ADHD had a limited impact on the manifestation of anxiety disorder in children suggesting that ADHD and anxiety disorders are independently expressed.
Literature
1.
go back to reference Anderson JC, Williams S, McGee R, Silva PA (1987) DSM-III disorders in preadolescent children: prevalence in a large sample from the general population. Arch Gen Psychiatry 44:69–76PubMed Anderson JC, Williams S, McGee R, Silva PA (1987) DSM-III disorders in preadolescent children: prevalence in a large sample from the general population. Arch Gen Psychiatry 44:69–76PubMed
2.
go back to reference Biederman J, Faraone SV, Keenan K, Steingard R, Tsuang MT (1991) Familial association between attention deficit disorder and anxiety disorders. Am J Psychiatry 148:251–256PubMed Biederman J, Faraone SV, Keenan K, Steingard R, Tsuang MT (1991) Familial association between attention deficit disorder and anxiety disorders. Am J Psychiatry 148:251–256PubMed
3.
go back to reference Biederman J, Faraone SV, Mick E, Williamson S, Wilens TE, Spencer TJ, Weber W, Jetton J, Kraus I, Pert J, Zallen B (1999) Clinical correlates of ADHD in females: findings from a large group of girls ascertained from pediatric and psychiatric referral sources. J Am Acad Child Adolesc Psychiatry 38:966–975PubMedCrossRef Biederman J, Faraone SV, Mick E, Williamson S, Wilens TE, Spencer TJ, Weber W, Jetton J, Kraus I, Pert J, Zallen B (1999) Clinical correlates of ADHD in females: findings from a large group of girls ascertained from pediatric and psychiatric referral sources. J Am Acad Child Adolesc Psychiatry 38:966–975PubMedCrossRef
4.
go back to reference Braaten E, Biederman J, Monuteaux M, Mick E, Calhoun E, Cattan G, Faraone S (2003) Revisiting the association between attention deficit hyperactivity disorder and anxiety disorders: a familial risk analysis. Biol Psychiatry 53:93–99CrossRefPubMed Braaten E, Biederman J, Monuteaux M, Mick E, Calhoun E, Cattan G, Faraone S (2003) Revisiting the association between attention deficit hyperactivity disorder and anxiety disorders: a familial risk analysis. Biol Psychiatry 53:93–99CrossRefPubMed
5.
go back to reference Byun H, Yang J, Lee M, Jang W, Yang JW, Kim JH, Hong SD, Joung YS (2006) Psychiatric comorbidity in Korean children and adolescents with attention-deficit hyperactivity disorder: psychopathology according to subtype. Yonsei Med J 47:113–121CrossRefPubMed Byun H, Yang J, Lee M, Jang W, Yang JW, Kim JH, Hong SD, Joung YS (2006) Psychiatric comorbidity in Korean children and adolescents with attention-deficit hyperactivity disorder: psychopathology according to subtype. Yonsei Med J 47:113–121CrossRefPubMed
6.
go back to reference Chavira DA, Stein MB, Bailey K, Stein MT (2004) Child anxiety in primary care: prevalent but untreated. Depress Anxiety 20:155–164CrossRefPubMed Chavira DA, Stein MB, Bailey K, Stein MT (2004) Child anxiety in primary care: prevalent but untreated. Depress Anxiety 20:155–164CrossRefPubMed
7.
go back to reference Costello EJ, Egger HL, Angold A (2005) The developmental epidemiology of anxiety disorders: phenomenology, prevalence, and comorbidity. Child Adolesc Psychiatr Clin N Am 14:631–648 viiCrossRefPubMed Costello EJ, Egger HL, Angold A (2005) The developmental epidemiology of anxiety disorders: phenomenology, prevalence, and comorbidity. Child Adolesc Psychiatr Clin N Am 14:631–648 viiCrossRefPubMed
8.
go back to reference Diamond IR, Tannock R, Schachar RJ (1999) Response to methylphenidate in children with ADHD and comorbid anxiety. J Am Acad Child Adolesc Psychiatry 38:402–409CrossRefPubMed Diamond IR, Tannock R, Schachar RJ (1999) Response to methylphenidate in children with ADHD and comorbid anxiety. J Am Acad Child Adolesc Psychiatry 38:402–409CrossRefPubMed
9.
go back to reference Geller DA, Coffey B, Faraone S, Hagermoser L, Zaman NK, Farrell CL, Mullin B, Biederman J (2003) Does comorbid attention-deficit/hyperactivity disorder impact the clinical expression of pediatric obsessive-compulsive disorder? CNS Spectr 8:259–264PubMed Geller DA, Coffey B, Faraone S, Hagermoser L, Zaman NK, Farrell CL, Mullin B, Biederman J (2003) Does comorbid attention-deficit/hyperactivity disorder impact the clinical expression of pediatric obsessive-compulsive disorder? CNS Spectr 8:259–264PubMed
10.
go back to reference Hollingshead AB (1975) Four factor index of social status. Yale Press, New Haven Hollingshead AB (1975) Four factor index of social status. Yale Press, New Haven
11.
go back to reference Masi G, Millepiedi S, Mucci M, Bertini N, Pfanner C, Arcangeli F (2006) Comorbidity of obsessive-compulsive disorder and attention-deficit/hyperactivity disorder in referred children and adolescents. Compr Psychiatry 47:42–47CrossRefPubMed Masi G, Millepiedi S, Mucci M, Bertini N, Pfanner C, Arcangeli F (2006) Comorbidity of obsessive-compulsive disorder and attention-deficit/hyperactivity disorder in referred children and adolescents. Compr Psychiatry 47:42–47CrossRefPubMed
12.
go back to reference MTA Cooperative Group (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal treatment study of children with ADHD. Arch Gen Psychiatry 56:1073–1086CrossRef MTA Cooperative Group (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal treatment study of children with ADHD. Arch Gen Psychiatry 56:1073–1086CrossRef
13.
go back to reference Orvaschel H, Puig-Antich J (1987) Schedule for affective disorders and schizophrenia for school-age children: epidemiologic version. Nova University, Fort Lauderdale, FL Orvaschel H, Puig-Antich J (1987) Schedule for affective disorders and schizophrenia for school-age children: epidemiologic version. Nova University, Fort Lauderdale, FL
14.
go back to reference Perrin S, Last CG (1996) Relationship between ADHD and anxiety in boys: results from a family study. J Am Acad Child Adolesc Psychiatry 35:988–996CrossRefPubMed Perrin S, Last CG (1996) Relationship between ADHD and anxiety in boys: results from a family study. J Am Acad Child Adolesc Psychiatry 35:988–996CrossRefPubMed
15.
go back to reference Pliszka SR (1989) Effect of anxiety on cognition, behavior, and stimulant response in ADHD. J Am Acad Child Adolesc Psychiatry 28:882–887CrossRefPubMed Pliszka SR (1989) Effect of anxiety on cognition, behavior, and stimulant response in ADHD. J Am Acad Child Adolesc Psychiatry 28:882–887CrossRefPubMed
16.
go back to reference Schatz DB, Rostain AL (2006) ADHD with comorbid anxiety: a review of the current literature. J Atten Disord 10:141–149CrossRefPubMed Schatz DB, Rostain AL (2006) ADHD with comorbid anxiety: a review of the current literature. J Atten Disord 10:141–149CrossRefPubMed
17.
go back to reference Spitzer RL, Williams JB, Gibbon M, First MB (1990) Structured clinical interview for DSM-III-R: non-patient edition (SCID-NP, Version 1.0). American Psychiatric Press, Washington, DC Spitzer RL, Williams JB, Gibbon M, First MB (1990) Structured clinical interview for DSM-III-R: non-patient edition (SCID-NP, Version 1.0). American Psychiatric Press, Washington, DC
18.
go back to reference Tannock R, Ickowicz A, Schachar R (1995) Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety. J Am Acad Child Adolesc Psychiatry 34:886–896CrossRefPubMed Tannock R, Ickowicz A, Schachar R (1995) Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety. J Am Acad Child Adolesc Psychiatry 34:886–896CrossRefPubMed
19.
go back to reference Wang PS, Berglund P, Olfson M, Pincus HA, Wells KB, Kessler RC (2005) Failure and delay in initial treatment contact after first onset of mental disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:603–613CrossRefPubMed Wang PS, Berglund P, Olfson M, Pincus HA, Wells KB, Kessler RC (2005) Failure and delay in initial treatment contact after first onset of mental disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:603–613CrossRefPubMed
20.
go back to reference Wilens T, Biederman J, Brown S, Tanguay S, Monuteaux M, Blake C, Spencer T (2002) Psychiatric comorbidity and functioning in clinically referred preschoolers and school aged youth with ADHD. J Am Acad Child Adolesc Psychiatry 41:262–268CrossRefPubMed Wilens T, Biederman J, Brown S, Tanguay S, Monuteaux M, Blake C, Spencer T (2002) Psychiatric comorbidity and functioning in clinically referred preschoolers and school aged youth with ADHD. J Am Acad Child Adolesc Psychiatry 41:262–268CrossRefPubMed
Metadata
Title
Does ADHD moderate the manifestation of anxiety disorders in children?
Authors
Paul Hammerness
Daniel Geller
Carter Petty
Alexis Lamb
Elyssa Bristol
Joseph Biederman
Publication date
01-02-2010
Publisher
D. Steinkopff-Verlag
Published in
European Child & Adolescent Psychiatry / Issue 2/2010
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-009-0041-8

Other articles of this Issue 2/2010

European Child & Adolescent Psychiatry 2/2010 Go to the issue