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AIDS and Behavior
Published in: AIDS and Behavior 3/2019

01-03-2019 | Original Paper

Do Symptoms of Depression Interact with Substance Use to Affect HIV Continuum of Care Outcomes?

Authors: Anthony T. Fojo, Catherine R. Lesko, Keri L. Calkins, Richard D. Moore, Mary E. McCaul, Heidi E. Hutton, William C. Mathews, Heidi Crane, Katerina Christopoulos, Karen Cropsey, Michael J. Mugavero, Kenneth Mayer, Brian W. Pence, Bryan Lau, Geetanjali Chander

Published in: AIDS and Behavior | Issue 3/2019

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Abstract

Few studies examine how depression and substance use interact to affect HIV control. In 14,380 persons with HIV (PWH), we used logistic regression and generalized estimating equations to evaluate how symptoms of depression interact with alcohol, cocaine, opioid, and methamphetamine use to affect subsequent retention in care, maintaining an active prescription for ART, and consistent virologic suppression. Among PWH with no or mild depressive symptoms, heavy alcohol use had no association with virologic suppression (OR 1.00 [0.95–1.06]); among those with moderate or severe symptoms, it was associated with reduced viral suppression (OR 0.80 [0.74–0.87]). We found no interactions with heavy alcohol use on retention in care or maintaining ART prescription or with other substances for any outcome. These results highlight the importance of treating moderate or severe depression in PWH, especially with comorbid heavy alcohol use, and support multifaceted interventions targeting alcohol use and depression.
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Metadata
Title
Do Symptoms of Depression Interact with Substance Use to Affect HIV Continuum of Care Outcomes?
Authors
Anthony T. Fojo
Catherine R. Lesko
Keri L. Calkins
Richard D. Moore
Mary E. McCaul
Heidi E. Hutton
William C. Mathews
Heidi Crane
Katerina Christopoulos
Karen Cropsey
Michael J. Mugavero
Kenneth Mayer
Brian W. Pence
Bryan Lau
Geetanjali Chander
Publication date
01-03-2019
Publisher
Springer US
Published in
AIDS and Behavior / Issue 3/2019
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-018-2269-0

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