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Critical Care
Published in: Critical Care 1/2015

Open Access 01-12-2015 | Research

Do alcohol use disorders impact on long term outcomes from intensive care?

Authors: Joanne M McPeake, Martin Shaw, Anna O’Neill, Ewan Forrest, Alex Puxty, Tara Quasim, John Kinsella

Published in: Critical Care | Issue 1/2015

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Abstract

Introduction

There is limited evidence regarding the impact of alcohol use disorders on long term outcomes from intensive care. The aims of this study were to analyse the nature and complications of alcohol related admissions to intensive care and determine whether alcohol use disorders impact on survival at six months post ICU discharge.

Method

This was an 18 month prospective observational cohort study in a 20 bedded mixed ICU, in a large teaching hospital in Scotland. On admission patients were allocated to one of three alcohol groups: low risk, harmful/hazardous, or alcohol dependency.

Results

34.4% of patients were admitted with an alcohol use disorder. Those with an alcohol related admission (either harmful/hazardous or alcohol dependent) had an increased odds of developing septic shock during their admission, compared with the low risk group (OR 1.67; 95% CI 1.13-2.47, p = 0.01). After adjustment for all lifestyle factors which were significantly different between the groups, alcohol dependence was associated with more than a twofold increased odds of ICU mortality (OR 2.28; 95% CI 1.2-4.69, p = 0.01) and hospital mortality (OR 2.43; 95% CI 1.28-4.621, p = 0.004). After adjustment for deprivation category and age, alcohol dependence was associated with an almost two fold increased odds of mortality at six months post ICU discharge (HR 1.86; CI 1.30-2.70, p = 0.001).

Conclusion

Alcohol use disorders are a significant risk factor for the development of septic shock in intensive care. Further, alcohol dependency is independently associated with poorer long term outcomes from intensive care.
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Metadata
Title
Do alcohol use disorders impact on long term outcomes from intensive care?
Authors
Joanne M McPeake
Martin Shaw
Anna O’Neill
Ewan Forrest
Alex Puxty
Tara Quasim
John Kinsella
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-0909-6

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