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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2017

Open Access 01-12-2017 | Case report

Distal appendicular skeletal involvement of diffuse large B-cell lymphoma on technetium-99m methylenediphosphonate bone scintigraphy and 18F-fluorodeoxyglucose positron emission tomography/computed tomography: a case report

Authors: Insook Park, Sungmin Kang

Published in: Journal of Medical Case Reports | Issue 1/2017

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Abstract

Background

We report a case of a patient with appendicular bone involvement of diffuse large B-cell lymphoma visualized by whole-body technetium-99m methylenediphosphonate bone scintigraphy (bone scan) and 18F-fluorodeoxyglucose positron emission tomography/computed tomography.

Case presentation

A 73-year-old Asian man who had gingival swelling of the labial area of the left maxillary lateral incisor presented to our institution. Positron emission tomography/computed tomography demonstrated hypermetabolic lesions with maximum standardized uptake values of 12.15 in the left testis, 1.92 in the skin of the right chest, and 2.88 in the left ulna and third metatarsal bone. A bone scan showed multiple uptakes in the left ulna, hand, both tibiae, and the left foot. We diagnosed the tumor as diffuse large B-cell lymphoma by excision. Magnetic resonance imaging showed enhanced signaling of lesions with soft tissue edema in the olecranon of the left ulna, the third metacarpal bone of the left hand, and the third metatarsal bone of the left foot. Magnetic resonance imaging findings prompted a diagnosis of lymphoma. Eight cycles of chemotherapy plus external radiotherapy targeted to the involved bone sites were given for 5 months. Follow-up positron emission tomography/computed tomography and bone scanning revealed the disappearance of hypermetabolism and decreased uptake in lesions compared with the previous images. Laboratory data were also all within the normal limits after chemotherapy.

Conclusions

This report highlights that appendicular bone involvement of diffuse large B-cell lymphoma can be detected on whole-body bone scans and by positron emission tomography/computed tomography.
Literature
1.
2.
Beal K, Allen L, Yahalom J. Primary bone lymphoma: treatment results and prognostic factors with long-term follow-up of 82 patients. Cancer. 2006;106:2652–6.CrossRefPubMed
3.
Chen YW, Huang MY, Hsieh JS, Hou MF, Chou SH, Lin CL. Discordant findings of skeletal metastasis between Tc99m MDP bone scans and F18 FDG PET/CT imaging for advanced breast and lung cancers—two case reports and literature review. Kaohsiung J Med Sci. 2007;23:639–46.CrossRefPubMed
4.
Chung DS, Kang S, Park JB. Incidental finding of appendiceal adenocarcinoma in F-18 FDG PET/CT for health screening. Nucl Med Mol Imaging. 2012;46:308–10.CrossRefPubMedPubMedCentral
5.
Mohan K, Simeone F, Parada N. A 79-year-old man with chest wall pain and a rapidly growing mass. Chest. 2009;135:221–4.CrossRefPubMed
6.
Møller MB, Pedersen NT, Christensen BE. Diffuse large B-cell lymphoma: clinical implications of extranodal versus nodal presentation – a population-based study of 1575 cases. Br J Haematol. 2004;124:151–9.CrossRefPubMed
7.
Zhang Y, Zhao C, Liu H, Hou H, Zhang H. Multiple metastasis-like bone lesions in scintigraphic imaging. J Biomed Biotechnol. 2012;2012:957364.PubMedPubMedCentral
8.
Airaghi L, Greco I, Carrabba M, Barcella M, Baldini IM, Bonara P, et al. Unusual presentation of large B cell lymphoma: a case report and review of literature. Clin Lab Haematol. 2006;28:338–42.CrossRefPubMed
9.
Kumar R, Maillard I, Schuster SJ, Alavi A. Utility of fluorodeoxyglucose-PET imaging in the management of patients with Hodgkin’s and non-Hodgkin’s lymphomas. Radiol Clin North Am. 2004;42:1083–100.CrossRefPubMed
10.
Meignan M, Haioun C, Itti E, Rahmouni A, Reyes F. Value of [18F]fluorodeoxyglucose-positron emission tomography in managing patients with aggressive non-Hodgkin’s lymphoma. Clin Lymphoma Myeloma. 2006;6:306–13.CrossRefPubMed
11.
Ostrowski ML, Unni KK, Banks PM, Shives TC, Evans RG, O’Connell MJ, et al. Malignant lymphoma of bone. Cancer. 1986;58:2646–55.CrossRefPubMed
12.
Malloy PC, Fishman EK, Magid D. Lymphoma of bone, muscle, and skin: CT findings. AJR Am J Roentgenol. 1992;159:805–9.CrossRefPubMed
13.
O’Neill J, Finlay K, Jurriaans E, Friedman L. Radiological manifestations of skeletal lymphoma. Curr Probl Diagn Radiol. 2009;38:228–36.CrossRefPubMed
Metadata
Title
Distal appendicular skeletal involvement of diffuse large B-cell lymphoma on technetium-99m methylenediphosphonate bone scintigraphy and 18F-fluorodeoxyglucose positron emission tomography/computed tomography: a case report
Authors
Insook Park
Sungmin Kang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2017
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/s13256-017-1246-y

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