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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2020

Open Access 01-12-2020 | Case report

Disseminated melioidosis in early pregnancy - an unproven cause of foetal loss

Authors: Chee Yik Chang, Nina Lee Jing Lau, Bart J. Currie, Yuwana Podin

Published in: BMC Infectious Diseases | Issue 1/2020

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Abstract

Background

Melioidosis is a potentially life-threatening infection caused by the Gram-negative bacterium Burkholderia pseudomallei. Melioidosis is difficult to diagnose due to its diverse clinical manifestations, which often delays administration of appropriate antibiotic therapy.

Case presentation

Melioidosis is uncommon in pregnancy but both spontaneous abortion and neonatal melioidosis have been reported. We report a case of bacteraemic melioidosis in a young woman with a subsequent spontaneous abortion, with B. pseudomallei cultured from a high vaginal swab as well as blood.

Conclusion

It remains unclear in this and previously reported cases as to whether the maternal melioidosis was sexually transmitted.
Literature
1.
Limmathurotsakul D, Golding N, Dance DAB, et al. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol. 2016;1(1):15008.CrossRef
2.
Currie BJ, Ward L, Cheng AC. The epidemiology and clinical Spectrum of Melioidosis: 540 cases from the 20 year Darwin prospective study. PLoS Negl Trop Dis. 2010;4(11):e900.CrossRef
3.
Cheng AC, Currie BJ. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev. 2005;18(2):383.CrossRef
4.
Webling DD. Genito-urinary infections with Pseudomonas pseudomallei in Australian aboriginals. Trans R Soc Trop Med Hyg. 1980;74(1):138–9.CrossRef
5.
McCormick JB, Sexton DJ, McMurray JG, Carey E, Hayes P, Feldman RA. Human-to-human transmission of Pseudomonas pseudomallei. Ann Intern Med. 1975;83(4):512.CrossRef
6.
Watson AK, Ellington S, Nelson C, Treadwell T, Jamieson DJ, Meaney-Delman DM. Preparing for biological threats: addressing the needs of pregnant women. Birth Defects Res. 2017;109(5):391–8.CrossRef
7.
Podin Y, Sarovich DS, Price EP, Kaestli M, Mayo M, et al. Burkholderia pseudomallei isolates from Sarawak, Malaysian Borneo, are predominantly susceptible to aminoglycosides and macrolides. Antimicrob Agents Chemother. 2014;58(1):162–6.CrossRef
8.
Novak RT, et al. Development and evaluation of a real-time PCR assay targeting the type III secretion system of Burkholderia pseudomallei. J Clin Microbiol. 2006;44(1):85–90.CrossRef
9.
How SH, Ng TH, Jamalludin AR, Tee HP, Kuan YC, Alex F, et al. Pahang melioidosis registry. Med J Malaysia. 2009;64(1):27–30.PubMed
10.
Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, et al. Melioidosis. Nat Rev Dis Prim. 2018;4:17107.CrossRef
11.
Currie BJ, Fisher DA, Howard DM, Burrow JNC, Lo D, Selvanayagam S, et al. Endemic Melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature. Clin Infect Dis. 2000;31(4):981–6.CrossRef
12.
Suputtamongkol Y, Chaowagul W, Chetchotisakd P, Lertpatanasuwun N, Intaranongpai S, Ruchutrakool T, et al. Risk factors for Melioidosis and Bacteremic Melioidosis. Clin Infect Dis. 1999;29(2):408–13.CrossRef
13.
Nathan S, Chieng S, Kingsley P, Mohan A, Podin Y, Ooi MH, et al. Melioidosis in Malaysia: incidence, clinical challenges, and advances in understanding pathogenesis. Trop Med Infect Dis. 2018;3(1):25.CrossRef
14.
Teparrukkul P, Kongkasame W, Chitsaeng S, Wongsuwan G, Wuthiekanun V, Peacock SJ, et al. Gastrointestinal tract involvement in melioidosis. Trans R Soc Trop Med Hyg. 2017;111(4):185–7.CrossRef
15.
Pagalavan L. Melioidosis: the Johor Bahru experience. Med J Malaysia. 2005;60(5):599–605.PubMed
16.
Abbink FC, Orendi JM, de Beaufort AJ. Mother-to-child transmission of Burkholderia pseudomallei. N Engl J Med. 2001;344(15):1171–2.CrossRef
17.
Porter MC, Pennell CE, Woods P, Dyer J, Merritt AJ, Currie BJ. Case report: Chorioamnionitis and premature delivery due to Burkholderia pseudomallei infection in pregnancy. Am J Trop Med Hyg. 2018;98(3):797–9.CrossRef
18.
Thatrimontrichai A, Maneenil G. Neonatal melioidosis: systemic review of the literature. Pediatr Infect Dis J. 2002;31:1195–7.CrossRef
19.
Low Choy J, Mayo M, Janmaat A, Currie BJ. Animal melioidosis in Australia. Acta Trop. 2000;74:153–8.CrossRef
20.
Thomas AD, Forbes-Faulkner JC, Norton JH, Trueman KF. Clinical and pathological observations on goats experimentally infected with Pseudomonas pseudomallei. Aust Vet J. 1988;65:43–6.CrossRef
21.
Adams Waldorf KM, McAdams RM. Influence of infection during pregnancy on fetal development. Reproduction. 2013;146(5):R151–62.CrossRef
Metadata
Title
Disseminated melioidosis in early pregnancy - an unproven cause of foetal loss
Authors
Chee Yik Chang
Nina Lee Jing Lau
Bart J. Currie
Yuwana Podin
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2020
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-020-4937-8

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