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Indian Journal of Pediatrics
Published in: Indian Journal of Pediatrics 5/2024

23-11-2023 | Disseminated Intravascular Coagulation | Scientific Letter

Role of MDA5 Deficiency in Pathogenesis of Fungal Infections

Authors: Anisha Goyal, Adiba Shakeel, Anu Maheshwari, Deonath Mahto

Published in: Indian Journal of Pediatrics | Issue 5/2024

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Excerpt

To the Editor: Multiple molecules which sense viruses and trigger IFN1 secretion include toll-like receptors, Retinoic acid-inducible gene I (RIG-I) and Melanoma Differentiation-Associated protein 5 (MDA5), collectively known as the RIG-I-like receptors (RLRs). They sense viral double-stranded RNA motifs to induce expression of IFN1 and other pro-inflammatory cytokines during the early stage of viral infection [1]. MDA5 is encoded by interferon induced with helicase C domain - containing protein 1 (IFIH1) gene located on chromosome 2q24.2 of human gene. The loss of function mutations of IFIH1 gene lead to MDA5 deficiency leading to recurrent viral infections [2]. …
Literature
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2.
3.
Jaeger M, van der Lee R, Cheng SC, et al. The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections. Eur J Clin Microbiol Infect Dis. 2015;34:963–74.CrossRefPubMedPubMedCentral
4.
Wang X, Caffrey-Carr AK, Liu KW, et al. MDA5 is an essential sensor of a pathogen-associated molecular pattern associated with vitality that is necessary for host resistance against Aspergillus Fumigatus. J Immunol. 2020;205:3058–70.CrossRefPubMed
Metadata
Title
Role of MDA5 Deficiency in Pathogenesis of Fungal Infections
Authors
Anisha Goyal
Adiba Shakeel
Anu Maheshwari
Deonath Mahto
Publication date
23-11-2023
Publisher
Springer India
Published in
Indian Journal of Pediatrics / Issue 5/2024
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-023-04948-4

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