Published in:
01-01-2006 | Case Reports
Disseminated Intravascular Coagulation Associated With Systemic Cytomegalovirus Infection During Cyclosporine Therapy for Ulcerative Colitis: Report of a Case
Authors:
Kenji Hibi, M.D., Kazuo Kusugami, M.D., Kenji Ina, M.D., Takafumi Ando, M.D., Yoshinao Komatsu, M.D., Yasuhiro Kodera, M.D., Katsuki Ito, M.D., Seiji Akiyama, M.D., Tetsuro Nagasaka, M.D., Hidemi Goto, M.D., Akimasa Nakao, M.D.
Published in:
Diseases of the Colon & Rectum
|
Issue 1/2006
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Excerpt
Infection with cytomegalovirus (CMV), a ubiquitous virus of the Herpes group, is manifested by a variety of symptoms because of its association with multiple organ pathology.
1 Since Powell
et al. first reported the association of CMV with ulcerative colitis (UC) in 1961,
2 this infection has been described as a relatively rare condition that can exacerbate UC. Evidence from published reports suggests a triggering role of CMV in the occurrence of a more severe clinical course, mainly in patients with steroid refractory disease.
3‐
11 CMV infection might not be suspected until histopathologic review of colonoscopic biopsy specimens, and unrecognized infection during medical management of UC may lead to fulminant disease requiring colectomy or may even cause death if not treated early.
3,
11 Because the majority of CMV colitis cases occur on the basis of a deficiency in cell-mediated immunity,
1 the use of immunosuppressive treatment with steroids, thiopurines, and/or cyclosporine could become a risk for CMV infection or reactivation in patients with UC.
8,
11 …
