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BMC Cancer
Published in: BMC Cancer 1/2016

Open Access 01-12-2016 | Case report

Disseminated carcinomatosis of the bone marrow from pancreatic cancer: a case report

Authors: Hiroki Namikawa, Yasuhiko Takemoto, Ayako Makuuchi, Masanori Kobayashi, Shigeki Kinuhata, Mina Morimura, Takashi Ikebe, Hiromu Tanaka, Taichi Shuto

Published in: BMC Cancer | Issue 1/2016

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Abstract

Background

Most cases of disseminated carcinomatosis of the bone marrow (DCBM) arise from gastric cancer. DCBM from pancreatic cancer is very rare. We herein present a case of DCBM from pancreatic cancer.

Case presentation

A 57-year-old man was referred to our hospital for severe lumbago. Laboratory data indicated that he suffered from disseminated intravascular coagulation (DIC). Non-contrast abdominal computed tomography (CT) revealed multiple bone masses but no other abnormal findings. Left iliac bone marrow biopsy revealed poorly differentiated adenocarcinoma cells. Positron emission tomography (PET)-CT showed diffuse abnormal uptake in the bones and tail of the pancreas. Contrast whole-body CT showed a tumor measuring approximately 28 mm in diameter with poor enhancement in the tail of the pancreas. The patient’s final diagnosis was pancreatic cancer located in the tail of the pancreas with diffuse bone metastases and DIC. His DCBM was thus believed to originate from the pancreatic cancer. He succumbed to the disease approximately 2 months after admission to our hospital.

Conclusion

We herein describe a case of pancreatic cancer located in the tail of the pancreas with diffuse bone metastases and DIC, which, in our case, was DCBM. Therefore, in cases of DCBM with an unknown primary tumor, pancreatic cancer should be considered during differential diagnosis.
Literature
1.
Hayashi H, Haruyama H, Emura Y, Kaizuka I, Ozeki T. Disseminated carcinomatosis of the bone marrow – Study of a type of metastatic cancer and relationship of microangiopathic hemolytic anemia or disseminated intravascular coagulation. Jpn J Cancer Clin. 1979;25(4):329.
2.
Rhee J, Han SW, Oh DY, Im SA, Kim TY, Bang YJ. Clinicopathologic features and clinical outcomes of gastric cancer that initially presents with disseminated intravascular coagulation: a retrospective study. J Gastroenterol Hepatol. 2010;25(9):1537–42.CrossRefPubMed
3.
Ikarashi M, Wakabayashi K, Omori K, Ebisawa K, Yamada K, Itou Y. A case of early gastric cancer complicated with UL-IV gastric ulcer with super bone scan. Jpn J of Gastroenterol Surg. 2012;45(2):139.CrossRef
4.
Jarcho S. Diffusely infiltrative carcinoma. A hitherto undescribed correlation of several varieties of tumor metastasis. Arch Pathol. 1936;22:674.
5.
Hasuda N, Koshizuka K, Oyachi N, Takano K, Matsumoto M. A case report of disseminated carcinomatosis of the bone marrow from early gastric cancer 4 years after operation. J Jpn Surg Assoc. 2008;69(2):355–9.CrossRef
6.
Nakamura K, Takamori H, Nakahara O, Ikuta Y, Kuroki H, Nakagawa S, Mima K, Okabe H, Nitta H, Imai K, Chikamoto A, Doi K, Ishiko T, Beppu T, Iyama K, Baba H. A case of cancer the pancreatic tail with disseminated carcinomatosis of the bone marrow. Jpn J Canc Chemother. 2012;39(8):1275–7.
7.
Yamamura Y, Kito T, Yamada E. Clinical evaluation on bone and bone marrow metastasis of gastric carcinoma. Jpn Soc of Gastroenterol Surg. 1985;18(11):2288–93.CrossRef
8.
Karasawa E, Saisho H. Early diagnosis of carcinoma of the pancreas with emphasis on utility of ultrasonography. Jpn J Gastroenterol. 1989;86(12):2794–803.
9.
Kimura A, Kawasaki H, Wajima N, Nakai M, Nakayama Y, Yonaiyama S, Hakamada K. A case of rapidly fatal gastric cancer with disseminated carcinomatosis of the bone marrow. Jpn J Canc Chemother. 2013;40(12):2322–4.
10.
Yamagishi T, Miura K, Ninomiya H, Sasaki T, Katsumi R, Matsuba A. A case of disseminated carcinomatosis of bone marrow appeared by lumbago. Tohoku J Orthop Traumatol. 2010;54(1):80–3.
11.
Takeda A, Kawara F, Onishi K, Higashida A, Mamori S, Ashida C, Okutani T, Yamada H, Kondo T. A very elderly case of advanced gastric cancer with disseminated carcinomatosis of bone marrow and multiple bone metastases, diagnosed by extremely elevated serum alkaline phosphatase levels, and treated with low-dose S-1 to avoid disseminated intravascular coagulation. Nippon Shokakibyo Gakkai Zasshi. 2011;108(11):1879–85.PubMed
12.
Takeda H, Nishikawa H, Tsumura T, Sekikawa A, Maruo T, Okabe Y, Kimura T, Wakasa T, Osaki Y. Prominent hypereosinophilia with disseminated intravascular coagulation as an unusual presentation of advanced gastric cancer. Intern Med. 2014;53(6):563–9.CrossRefPubMed
13.
Kikuchi Y, Matsuzaki M, Tokura N, Kanayama K, Kanayama M, Shiratori M, Shinohara M, Igarashi Y, Sumino Y, Nakano K. Disseminated carcinomatosis of the bone marrow due to gastric cancer: analysis of cases at Toho University and in Japan. J Med Soc Toho. 2010;57(2):127–36.
Metadata
Title
Disseminated carcinomatosis of the bone marrow from pancreatic cancer: a case report
Authors
Hiroki Namikawa
Yasuhiko Takemoto
Ayako Makuuchi
Masanori Kobayashi
Shigeki Kinuhata
Mina Morimura
Takashi Ikebe
Hiromu Tanaka
Taichi Shuto
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2016
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-016-2849-1

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