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Open Access 01-12-2013 | Research article

Disrupted default mode network connectivity in migraine without aura

Authors: Alessandro Tessitore, Antonio Russo, Alfonso Giordano, Francesca Conte, Daniele Corbo, Manuela De Stefano, Sossio Cirillo, Mario Cirillo, Fabrizio Esposito, Gioacchino Tedeschi

Published in: The Journal of Headache and Pain | Issue 1/2013

Abstract

Background

Resting-state functional magnetic resonance imaging (RS-fMRI) has demonstrated disrupted default mode network (DMN) connectivity in a number of pain conditions, including migraine. However, the significance of altered resting-state brain functional connectivity in migraine is still unknown. The present study is aimed to explore DMN functional connectivity in patients with migraine without aura (MwoA) and investigate its clinical significance.

Methods

To calculate and compare the resting-state functional connectivity of the DMN in 20 patients with MwoA, during the interictal period, and 20 gender- and age-matched HC, Brain Voyager QX was used. Voxel-based morphometry was used to assess whether between-group differences in DMN functional connectivity were related to structural differences. Secondary analyses explored associations between DMN functional connectivity, clinical and neuropsychological features of migraineurs.

Results

In comparison to HC, patients with MwoA showed decreased connectivity in prefrontal and temporal regions of the DMN. Functional abnormalities were unrelated to detectable structural abnormalities or clinical and neuropsychological features of migraineurs.

Conclusions

Our study provides further evidence of disrupted DMN connectivity in patients with MwoA. We hypothesize that a DMN dysfunction may be related to behavioural processes such as a maladaptive response to stress which seems to characterize patients with migraine.

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Title: Disrupted default mode network connectivity in migraine without aura
Authors: Alessandro Tessitore
Antonio Russo
Alfonso Giordano
Francesca Conte
Daniele Corbo
Manuela De Stefano
Sossio Cirillo
Mario Cirillo
Fabrizio Esposito
Gioacchino Tedeschi
Publication date: 01-12-2013
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/1129-2377-14-89

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Disrupted default mode network connectivity in migraine without aura

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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