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Open Access 01-12-2020 | Research article

Disrupted brain network dynamics and cognitive functions in methamphetamine use disorder: insights from EEG microstates

Authors: Tianzhen Chen, Hang Su, Na Zhong, Haoye Tan, Xiaotong Li, Yiran Meng, Chunmei Duan, Congbin Zhang, Juwang Bao, Ding Xu, Weidong Song, Jixue Zou, Tao Liu, Qingqing Zhan, Haifeng Jiang, Min Zhao

Published in: BMC Psychiatry | Issue 1/2020

Abstract

Background

Dysfunction in brain network dynamics has been found to correlate with many psychiatric disorders. However, there is limited research regarding resting electroencephalogram (EEG) brain network and its association with cognitive process for patients with methamphetamine use disorder (MUD). This study aimed at using EEG microstate analysis to determine whether brain network dynamics in patients with MUD differ from those of healthy controls (HC).

Methods

A total of 55 MUD patients and 27 matched healthy controls were included for analysis. The resting brain activity was recorded by 64-channel electroencephalography. EEG microstate parameters and intracerebral current sources of each EEG microstate were compared between the two groups. Generalized linear regression model was used to explore the correlation between significant microstates with drug history and cognitive functions.

Results

MUD patients showed lower mean durations of the microstate classes A and B, and a higher global explained variance of the microstate class C. Besides, MUD patients presented with different current density power in microstates A, B, and C relative to the HC. The generalized linear model showed that MA use frequency is negatively correlated with the MMD of class A. Further, the generalized linear model showed that MA use frequency, scores of Two-back task, and the error rate of MA word are correlated with the MMD and GEV of class B, respectively.

Conclusions

Intracranial current source densities of resting EEG microstates are disrupted in MUD patients, hence causing temporal changes in microstate topographies, which are correlated with attention bias and history of drug use.

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Title: Disrupted brain network dynamics and cognitive functions in methamphetamine use disorder: insights from EEG microstates
Authors: Tianzhen Chen
Hang Su
Na Zhong
Haoye Tan
Xiaotong Li
Yiran Meng
Chunmei Duan
Congbin Zhang
Juwang Bao
Ding Xu
Weidong Song
Jixue Zou
Tao Liu
Qingqing Zhan
Haifeng Jiang
Min Zhao
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2020
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-020-02743-5

2024 ASCO Annual Meeting

Springer Medicine

Disrupted brain network dynamics and cognitive functions in methamphetamine use disorder: insights from EEG microstates

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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