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01-06-2018 | Original Article

Disease of mRNA Regulation: Relevance for Ischemic Brain Injury

Author: Donald J. DeGracia

Published in: Translational Stroke Research | Issue 3/2018

Abstract

In this mini-review we give an overview of the role of mRNA-binding proteins and their associated messenger ribonucleoprotein complexes (mRNPs) in several disease states, and bring this information to bear on the pathophysiology of brain ischemia. One conclusion reached is that mRNPs may play a causal role in proteotoxicity instead of being merely passive targets. Ischemia therapies targeting mRNPs have advantages over targeting single pathways, but the behavior of mRNPs needs to be considered in the design of therapies.

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Title: Disease of mRNA Regulation: Relevance for Ischemic Brain Injury
Author: Donald J. DeGracia
Publication date: 01-06-2018
Publisher: Springer US
Published in: Translational Stroke Research / Issue 3/2018
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-017-0586-7

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Disease of mRNA Regulation: Relevance for Ischemic Brain Injury

Abstract

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