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Social Psychiatry and Psychiatric Epidemiology

Published in:

01-12-2015 | Original Paper

Disease network of mental disorders in Korea

Authors: Myoungje Choi, Dong-Woo Lee, Maeng Je Cho, Jee Eun Park, Minsook Gim

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 12/2015

Abstract

Purpose

Network medicine considers networks among genes, diseases, and individuals. Networks of mental disorders remain poorly understood, despite their high comorbidity. In this study, a network of mental disorders in Korea was constructed to offer a complementary approach to treatment.

Methods

Data on the prevalence and morbidity of mental disorders were obtained from the 2006 and 2011 Korean Epidemiologic Catchment Area Study, including 22 psychiatric disorders. Nodes in the network were disease phenotypes identified by Diagnostic and Statistical Manual of Mental Disorders-IV, and the links connected phenotypes showing significant comorbidity. Odds ratios were used to quantify the distance between disease pairs. Network centrality was analyzed with and without weighting of the links between disorders. Degree centrality was correlated with suicidal behaviors and use of mental health services.

Results

In 2011 and 2006, degree centrality was highest for major depressive disorder, followed by nicotine dependence and generalized anxiety disorder (2011) or alcohol dependence (2006). Weighted degree centrality was highest in conversion disorder in both years.

Conclusions

Therefore, major depressive disorder and nicotine dependence are highly connected to other mental disorders in Korea, indicating their comorbidity and possibility of shared biological mechanisms. The use of networks could enhance the understanding of mental disorders to provide effective mental health services.

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Title: Disease network of mental disorders in Korea
Authors: Myoungje Choi
Dong-Woo Lee
Maeng Je Cho
Jee Eun Park
Minsook Gim
Publication date: 01-12-2015
Publisher: Springer Berlin Heidelberg
Published in: Social Psychiatry and Psychiatric Epidemiology / Issue 12/2015
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-015-1106-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Disease network of mental disorders in Korea

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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