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Cancer Cell International
Published in: Cancer Cell International 1/2022

Open Access 01-12-2022 | Review

Disease-associated regulation of gene expression by resveratrol: Special focus on the PI3K/AKT signaling pathway

Authors: Soudeh Ghafouri-Fard, Zahra Bahroudi, Hamed Shoorei, Bashdar Mahmud Hussen, Seyedeh Fahimeh Talebi, Sadia Ghousia Baig, Mohammad Taheri, Seyed Abdulmajid Ayatollahi

Published in: Cancer Cell International | Issue 1/2022

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Abstract

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural phenol that is present in the skin of the grape, blueberry, raspberry, mulberry, and peanut. This substance is synthesized in these plants following injury or exposure to pathogens. Resveratrol is used as a dietary supplement for a long time and its effects have been assessed in animal models of human disorders. It has potential beneficial effects in diverse pathological conditions such as diabetes mellitus, obesity, hypertension, neoplastic conditions, Alzheimer's disease, and cardiovascular disorders. Notably, resveratrol has been found to affect the expression of several genes including cytokine coding genes, caspases, matrix metalloproteinases, adhesion molecules, and growth factors. Moreover, it can modulate the activity of several signaling pathways such as PI3K/AKT, Wnt, NF-κB, and Notch pathways. In the current review, we summarize the results of studies that reported modulatory effects of resveratrol on the expression of genes and the activity of signaling pathways. We explain these results in two distinct sections of non-neoplastic and neoplastic conditions.
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Metadata
Title
Disease-associated regulation of gene expression by resveratrol: Special focus on the PI3K/AKT signaling pathway
Authors
Soudeh Ghafouri-Fard
Zahra Bahroudi
Hamed Shoorei
Bashdar Mahmud Hussen
Seyedeh Fahimeh Talebi
Sadia Ghousia Baig
Mohammad Taheri
Seyed Abdulmajid Ayatollahi
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2022
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-022-02719-3

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Cancer Cell International 1/2022 Go to the issue

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The emerging role of deubiquitylating enzymes as therapeutic targets in cancer metabolism

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Noncoding RNA-mediated molecular bases of chemotherapy resistance in hepatocellular carcinoma

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GRB10 is a novel oncogene associated with cell proliferation and prognosis in glioma

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LncRNA HOTAIR impairs the prognosis of papillary thyroid cancer via regulating cellular malignancy and epigenetically suppressing DLX1

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Integrated regulation of chondrogenic differentiation in mesenchymal stem cells and differentiation of cancer cells

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The prognostic impact of the immune microenvironment in small-cell neuroendocrine carcinoma of the uterine cervix: PD-L1 and immune cell subtypes
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