Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2013

Open Access 01-12-2013 | Research article

Discovery by a proteomic approach of possible early biomarkers of drug-induced nephrotoxicity in medication-overuse headache

Authors: Elisa Bellei, Emanuela Monari, Aurora Cuoghi, Stefania Bergamini, Simona Guerzoni, Michela Ciccarese, Tomris Ozben, Aldo Tomasi, Luigi Alberto Pini

Published in: The Journal of Headache and Pain | Issue 1/2013

Login to get access

Abstract

Background

Medication-overuse headache (MOH) is a chronic headache condition that results from the overuse of analgesics drugs, triptans, or other antimigraine compounds. The epidemiology of drug-induced disorders suggests that medication overuse could lead to nephrotoxicity, particularly in chronic patients. The aim of this work was to confirm and extend the results obtained from a previous study, in which we analyzed the urinary proteome of 3 MOH patients groups: non-steroidal anti-inflammatory drugs (NSAIDs), triptans and mixtures abusers, in comparison with non-abusers individuals (controls).

Methods

In the present work we employed specialized proteomic techniques, namely two-dimensional gel electrophoresis (2-DE) coupled with mass spectrometry (MS), and the innovative Surface-Enhanced Laser Desorption/Ionization Time-of-Flight mass spectrometry (SELDI-TOF-MS), to discover characteristic proteomic profiles associated with MOH condition.

Results

By 2-DE and MS analysis we identified 21 over-excreted proteins in MOH patients, particularly in NSAIDs abusers, and the majority of these proteins were involved in a variety of renal impairments, as resulted from a literature search. Urine protein profiles generated by SELDI-TOF-MS analysis showed different spectra among groups. Moreover, significantly higher number of total protein spots and protein peaks were detected in NSAIDs and mixtures abusers.

Conclusions

These findings confirm the presence of alterations in proteins excretion in MOH patients. Analysis of urinary proteins by powerful proteomic technologies could lead to the discovery of early candidate biomarkers, that might allow to identify MOH patients prone to develop potential drug overuse-induced nephrotoxicity.
Appendix
Available only for authorised users
Literature
1.
International Classification of Headache Disorders, 2nd Edition: Headache Classification Subcommittee of the International Headache Society. Cephalalgia 2004,24(Suppl 1):8–152.
2.
Meng ID, Dodick D, Ossipov MH, Porreca F: Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies. Cephalalgia 2011,31(7):851–860. 10.1177/0333102411402367PubMedCrossRef
3.
Diener HC, Limmroth V: Medication-overuse headache: a worldwide problem. Lancet Neurol 2004, 3: 475–483. 10.1016/S1474-4422(04)00824-5PubMedCrossRef
4.
5.
Di Lorenzo C, Di Lorenzo G, Sances G, Ghiotto N, Guaschino E, Grieco GS, Santarelli FM, Casali C, Troisi A, Siracusano A, Pierelli F: Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism. J Headache Pain 2009, 10: 349–355. 10.1007/s10194-009-0136-0PubMedCentralPubMedCrossRef
6.
Davies P: Medication overuse headache: a silent pandemic. Pain 2012, 153: 7–8. 10.1016/j.pain.2011.10.021PubMedCrossRef
7.
Negro A, Martelletti P: Chronic migraine plus medication overuse headache: two entities or not? J Headache Pain 2011, 12: 593–601. 10.1007/s10194-011-0388-3PubMedCentralPubMedCrossRef
8.
Taber SS, Pasko DA: The epidemiology of drug-induced disorders: the kidney. Expert Opin Drug Saf 2008,7(6):679–690. 10.1517/14740330802410462PubMedCrossRef
9.
Bellei E, Cuoghi A, Monari E, Bergamini S, Fantoni LI, Zappaterra M, Guerzoni S, Bazzocchi A, Tomasi A, Pini LA: Proteomic analysis of urine in medication-overuse headache patients: possibile relation with renal damages. J Headache Pain 2012, 13: 45–52. 10.1007/s10194-011-0390-9PubMedCentralPubMedCrossRef
10.
Ferrari A, Savino G, Gallesi D, Pinetti D, Bertolini A, Sances G, Coccia CPR, Pasciullo G, Leone S, Loi M, Sternieri E: Effect of overuse of the antimigraine combination of indomethacin, prochlorperazine and caffeine (IPC) on the disposition of its components in chronic headache patients. Pharmacol Res 2006, 54: 142–149. 10.1016/j.phrs.2006.03.022PubMedCrossRef
11.
Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72: 248–254. 10.1016/0003-2697(76)90527-3PubMedCrossRef
12.
Bellei E, Rossi E, Lucchi L, Uggeri S, Albertazzi A, Tomasi A, Iannone A: Proteomic analysis of early urinary biomarkers of renal changes in type 2 diabetic patients. Proteomics Clin Appl 2008, 2: 478–491. 10.1002/prca.200780109PubMedCrossRef
13.
Bellei E, Monari E, Bergamini S, Ozben T, Tomasi A: Optimizing protein recovery yield from serum samples treated with beads technology. Electrophoresis 2011, 32: 1414–1421. 10.1002/elps.201000699PubMedCrossRef
14.
Bellei E, Bergamini S, Monari E, Fantoni LI, Cuoghi A, Ozben T, Tomasi A: High-abundance proteins depletion for serum proteomic analysis: concomitant removal of non-targeted proteins. Amino Acids 2011,40(1):145–156. 10.1007/s00726-010-0628-xPubMedCrossRef
15.
Dihazi H, Müller GA: Urinary proteomics: a tool to discover biomarkers of kidney diseases. Expert Rev Proteomics 2007,4(1):39–50. 10.1586/14789450.4.1.39PubMedCrossRef
16.
Julian BA, Suzuki H, Suzuki Y, Tomino Y, Spasovski G, Novak J: Sources of urinary proteins and their analysis by urinary proteomics for the detection of biomarkers of disease. Proteomics Clin Appl 2009, 3: 1029–1043. 10.1002/prca.200800243PubMedCentralPubMedCrossRef
17.
Bolisetty S, Agarwal A: Urine albumin as a biomarker in acute kidney injury. Am J Physiol Renal Physiol 2011, 300: F626-F627. 10.1152/ajprenal.00004.2011PubMedCentralPubMedCrossRef
18.
Hortin GL, Sviridov D: Analysis of molecular forms of albumin in urine. Proteomics Clin Appl 2008, 2: 950–955. 10.1002/prca.200780145PubMedCrossRef
19.
Khan TN, Sinniah R: Renal tubular antiproteinase (alpha-1-antitrypsin and alpha-1-antichymotrypsin) response in tubulo-interstitial damage. Nephron 1993,65(2):232–239. 10.1159/000187480PubMedCrossRef
20.
Markoff A, Gerke V: Expression and functions of annexins in the kidney. Am J Physiol Renal Physiol 2005, 289: F949-F956. 10.1152/ajprenal.00089.2005PubMedCrossRef
21.
Norden AGW, Fulcher LM, Lapsley M, Flynn FV: Excretion of β 2 -glycoprotein I (apolipoprotein H) in renal tubular disease. Clin Chem 1991,97(1):74–77.
22.
Ikeda A, Konta T, Takasaki S, Hao Z, Suzuki K, Sato H, Shibata Y, Takeishi Y, Kato T, Kawata S, Kubota I: In a non-diabetic Japanese population, the combination of macroalbuminuria and increased urine beta-2-microglobulin predicts a decline of renal function: the Takahata study. Nephrol Dial Transplant 2009, 24: 841–847.PubMedCrossRef
23.
Miyata T, Jadoul M, Kurokawa K, Ypersele V, de Strihou C: β-2 microglobulin in renal disease. J Am Soc Nephrol 1998, 9: 1723–1735.PubMed
24.
Roelofsen H, Alvarez-Llamas G, Schepers M, Landman K, Vonk RJ: Proteomics profiling of urine with surface enhanced laser desorption/ionization time of flight mass spectrometry. Proteome Sci 2007, 5: 2. 10.1186/1477-5956-5-2PubMedCentralPubMedCrossRef
25.
Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedcler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G: Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidnet injury. Nat Biotechnol 2010, 28: 463–469. 10.1038/nbt.1622PubMedCrossRef
26.
Hoffmann A, Nimtz M, Conradt HS: Molecular characterization of β-trace protein in human serum and urine: a potential diagnostic marker for renal diseases. Glycobiology 1997, 7: 499–506. 10.1093/glycob/7.4.499PubMedCrossRef
27.
Nakayama H, Echizen H, Gomi T, Shibuya Y, Nakamura Y, Nakano K, Arashi H, Itai T, Ohnishi S, Tanaka M, Orii T: Urinary lipocalin-type prostaglandin D synthase: a potentila marker for early gentamicin-induced renal damage? Ther Drug Monit 2009, 31: 126–130. 10.1097/FTD.0b013e31819566f1PubMedCrossRef
28.
Goldberg S, Harvey SJ, Cunningham J, Trayggvason K, Miner JH: Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane. Nephrol Dial Transplant 2009, 24: 2044–2051. 10.1093/ndt/gfn758PubMedCentralPubMedCrossRef
29.
Lobato L, Rocha A: Transthyretin amyloidosis and the kidney. Clin J Am Soc Nephrol 2012, 7: 1337–1346. 10.2215/CJN.08720811PubMedCrossRef
30.
Kamijo-Ikemori A, Sugaya T, Matsui K, Yokoyama T, Kimura K: Roles of human liver type farry acid binding protein in kidney disease clarified using hL-FABP chromosomal transgenic mice. Nephrology 2011, 16: 539–544. 10.1111/j.1440-1797.2011.01469.xPubMedCrossRef
31.
Kamijo A, Sugaya T, Hikawa A, Yamanouchi M, Hirata Y, Ishimitsu T, Numabe A, Takagi M, Hayakawa H, Tabei F, Sugimoto T, Mise N, Omata M, Kimura K: Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease. Mol Cell Biochem 2006, 284: 175–182. 10.1007/s11010-005-9047-9PubMedCrossRef
32.
Waring WS, Moonie A: Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury. Clin Toxicol 2011, 49: 720–728. 10.3109/15563650.2011.615319CrossRef
33.
Sleno L, Emili A: Proteomic methods for drug target discovery. Curr Opin Chem Biol 2008, 12: 46–54. 10.1016/j.cbpa.2008.01.022PubMedCrossRef
Metadata
Title
Discovery by a proteomic approach of possible early biomarkers of drug-induced nephrotoxicity in medication-overuse headache
Authors
Elisa Bellei
Emanuela Monari
Aurora Cuoghi
Stefania Bergamini
Simona Guerzoni
Michela Ciccarese
Tomris Ozben
Aldo Tomasi
Luigi Alberto Pini
Publication date
01-12-2013
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2013
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-14-6

Other articles of this Issue 1/2013

The Journal of Headache and Pain 1/2013 Go to the issue

Research article

Sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study

Research article

Association between somatic amplification, anxiety, depression, stress and migraine

Review article

Genes and primary headaches: discovering new potential therapeutic targets

Case report

New daily persistent headache with a thunderclap headache onset and complete response to Nimodipine (A new distinct subtype of NDPH)

Short report

New onset migraine with aura after treatment initiation with ivabradine

Editorial

Migraine: the seventh disabler