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Acta Neurochirurgica
Published in: Acta Neurochirurgica 12/2015

01-12-2015 | Letter to the editor - Brain Tumors

Disappearance of a metastatic brain tumor and achievement of long-term survival with a good quality of life after a combination of systemic chemotherapy with the P-glycoprotein inhibitor nifedipine in a patient with ovarian cancer

Authors: Toru Yanase, Akira Kikuchi, Motoi Sasagawa, Shigeru Honma

Published in: Acta Neurochirurgica | Issue 12/2015

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Excerpt

Dear Editor, …
Literature
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Hegmann EJ, Bauer HC, Kerbel RS (1992) Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells. Cancer Res 52:6969–6975PubMed
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Kondo S, Yin D, Morimura T, Kubo H, Nakatsu S, Takeuchi J (1995) Combination therapy with cisplatin and nifedipine induces apoptosis in cisplatin-sensitive and cisplatin-resistant human glioblastoma cells. Br J Cancer 71:282–289PubMedCentralCrossRefPubMed
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Matsukado K, Nomura T, Ikezaki K, Fukui M (1994) Selective increase in blood–tumor barrier permeability by calcium antagonists in transplanted rat brain tumors. Acta Neurochir Suppl (Wien) 60:403–405
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Onoda JM, Jacobs JR, Taylor JD, Sloane BF, Honn KV (1986) Cisplatin and nifedipine: synergistic cytotoxicity against murine solid tumors and their metastases. Cancer Lett 30:181–188CrossRefPubMed
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Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Roanus-Maandag EC, te Rele HP, Berns AJ, Borst P (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood–brain barrier and to increased sensitivity to drugs. Cell 77:491–502CrossRefPubMed
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Metadata
Title
Disappearance of a metastatic brain tumor and achievement of long-term survival with a good quality of life after a combination of systemic chemotherapy with the P-glycoprotein inhibitor nifedipine in a patient with ovarian cancer
Authors
Toru Yanase
Akira Kikuchi
Motoi Sasagawa
Shigeru Honma
Publication date
01-12-2015
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 12/2015
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-015-2580-8

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