Skip to main content
Top
Published in: PharmacoEconomics 9/2003

01-06-2003 | Original Research Article

Direct Treatment Costs for Patients with Lung Cancer from First Recurrence to Death in France

Authors: Anne-Chantal Brand, Christine Lévy-Piedbois, Pascal Piedbois, Youri Piedbois, Alain Livartovski, Béatrice Le Vu, Jean Trédaniel, François Reboul, Yvelise Brewer, Said Talbi, François Blanchon, Britta Paschen, Isabelle Durand-Zaleski

Published in: PharmacoEconomics | Issue 9/2003

Login to get access

Abstract

Objective: To determine the direct treatment cost of lung cancer management from progression to death from the viewpoint of the hospital.
Methods: A retrospective descriptive study was performed. Data from 100 patients who died of lung cancer and who had received treatment from four different types of hospital were used; the hospitals were public hospitals (teaching and non-teaching), private not-for-profit cancer centres, and private hospitals. Resource utilisation/cost data collected included the cost of diagnosis of the recurrence, the cost of hospitalisations or day care treatments and ambulatory surgery. All resources were valued in 2001 euros.
Results: In France, the average cost per patient was €12 518 for the whole group (78% with non-small cell lung cancer [NSCLC], and 22% with small cell lung cancer [SCLC]), €13 969 for patients with NSCLC and €7369 for patients with SCLC. The higher cost of treatment in patients with NSCLC is explained by longer survival and duration of chemotherapy. In patients with NSCLC, 51% of the total cost corresponded to terminal care, with up to seven lines of chemotherapy. In patients with SCLC, the costs of diagnosis and terminal care each represented 41% of the total cost.
Conclusion: The cost of treatment of recurrence of lung carcinoma is high, and is related to the number of lines of chemotherapy and the use of radiotherapy and surgery.
Literature
1.
2.
go back to reference Ochs JJ, Tester WJ, Cohen MH, et al. “Salvage” radiation therapy for intrathoracic small cell carcinoma of the lung progressing on combination chemotherapy. Cancer Treat Rep 1983; 67: 1123–6PubMed Ochs JJ, Tester WJ, Cohen MH, et al. “Salvage” radiation therapy for intrathoracic small cell carcinoma of the lung progressing on combination chemotherapy. Cancer Treat Rep 1983; 67: 1123–6PubMed
3.
go back to reference Veeder MH, Jett JR, Su JQ, et al. A phase III trial of mitomycin C alone versus mitomycin C, vinblastine, and cisplatin for metastatic squamous cell lung carcinoma. Cancer 1992; 70: 2281–7PubMedCrossRef Veeder MH, Jett JR, Su JQ, et al. A phase III trial of mitomycin C alone versus mitomycin C, vinblastine, and cisplatin for metastatic squamous cell lung carcinoma. Cancer 1992; 70: 2281–7PubMedCrossRef
4.
go back to reference Le Chevalier T, Brisgand D, Douillard JY, et al. Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: results of a European multicenter trial including 612 patients. J Clin Oncol 1994; 12: 360–7 Le Chevalier T, Brisgand D, Douillard JY, et al. Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: results of a European multicenter trial including 612 patients. J Clin Oncol 1994; 12: 360–7
5.
go back to reference Bonomi P, Kim K, Chang A, et al. Phase III trial comparing etoposide (E) cisplatin (C) versus taxol (T) with cisplatin-GCSF(G) versus taxol-cisplatin in advanced non-small cell lung cancer: an Eastern Cooperative Oncology Group (ECOG) trial [abstract 1145]. Proc Am Soc Clin Oncol 1996; 15: 382 Bonomi P, Kim K, Chang A, et al. Phase III trial comparing etoposide (E) cisplatin (C) versus taxol (T) with cisplatin-GCSF(G) versus taxol-cisplatin in advanced non-small cell lung cancer: an Eastern Cooperative Oncology Group (ECOG) trial [abstract 1145]. Proc Am Soc Clin Oncol 1996; 15: 382
6.
go back to reference Rosell R, Tonato M, Sandler A. The activity of gemcitabine plus cisplatin in randomized trials in untreated patients with advanced non-small cell lung cancer. Semin Oncol 1998; 25 (4 Suppl. 9): 27–34PubMed Rosell R, Tonato M, Sandler A. The activity of gemcitabine plus cisplatin in randomized trials in untreated patients with advanced non-small cell lung cancer. Semin Oncol 1998; 25 (4 Suppl. 9): 27–34PubMed
7.
go back to reference Johnson DH, Paul DM, Hande KR, et al. Paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a phase II trial. J Clin Oncol 1996; 14: 2054–60PubMed Johnson DH, Paul DM, Hande KR, et al. Paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a phase II trial. J Clin Oncol 1996; 14: 2054–60PubMed
8.
go back to reference Langer CJ, Leighton JC, Comis RL, et al. Paclitaxel and carboplatin in combination in the treatment of advanced non-small-cell lung cancer: a phase II toxicity, response, and survival analysis. J Clin Oncol 1995; 13: 1860–70PubMed Langer CJ, Leighton JC, Comis RL, et al. Paclitaxel and carboplatin in combination in the treatment of advanced non-small-cell lung cancer: a phase II toxicity, response, and survival analysis. J Clin Oncol 1995; 13: 1860–70PubMed
9.
go back to reference Arbil E, Wronski M, Burt M, et al. The treatment of patients with recurrent brain metastases: a retrospective analysis of 109 patients with non small cell lung cancer. Cancer 1995; 76: 765–73CrossRef Arbil E, Wronski M, Burt M, et al. The treatment of patients with recurrent brain metastases: a retrospective analysis of 109 patients with non small cell lung cancer. Cancer 1995; 76: 765–73CrossRef
10.
go back to reference Miller JI, Phillips TW. Neodymium: YAG laser and brachytherapy in the management of inoperable bronchogenic carcinoma. Ann Thorac Surg 1990; 50: 190–6PubMedCrossRef Miller JI, Phillips TW. Neodymium: YAG laser and brachytherapy in the management of inoperable bronchogenic carcinoma. Ann Thorac Surg 1990; 50: 190–6PubMedCrossRef
11.
go back to reference Wilson GE, Walshaw MJ, Hind CR. Treatment of large airway obstruction in lung cancer using expandable metal stents inserted under direct vision via the fibreoptic bronchoscope. Thorax 1996; 51: 248–52PubMedCrossRef Wilson GE, Walshaw MJ, Hind CR. Treatment of large airway obstruction in lung cancer using expandable metal stents inserted under direct vision via the fibreoptic bronchoscope. Thorax 1996; 51: 248–52PubMedCrossRef
12.
go back to reference Alexander E, Moriarty TM, Davis RB, et al. Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. J Natl Cancer Inst 1995; 87: 34–40PubMedCrossRef Alexander E, Moriarty TM, Davis RB, et al. Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. J Natl Cancer Inst 1995; 87: 34–40PubMedCrossRef
13.
go back to reference Löffler JS, Kooy HM, Wen PY, et al. The treatment of recurrent brain metastases with stereotactic radiosurgery. J Clin Oncol 1990; 8: 576–82 Löffler JS, Kooy HM, Wen PY, et al. The treatment of recurrent brain metastases with stereotactic radiosurgery. J Clin Oncol 1990; 8: 576–82
14.
go back to reference Drummond M, Torrance G, Stoddard G. Economic evaluation of healthcare programmes. Oxford: Oxford University Press, 1996 Drummond M, Torrance G, Stoddard G. Economic evaluation of healthcare programmes. Oxford: Oxford University Press, 1996
15.
go back to reference Oken MM, Creech RH, Horton DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982; 5: 649–55PubMedCrossRef Oken MM, Creech RH, Horton DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982; 5: 649–55PubMedCrossRef
16.
go back to reference Virgo KS, Naunheim KS, McKirgan LW, et al. Cost of patient follow-up after potentially curative lung cancer treatment. J Thorac Cardiovasc Surg 1996; 112: 356–63PubMedCrossRef Virgo KS, Naunheim KS, McKirgan LW, et al. Cost of patient follow-up after potentially curative lung cancer treatment. J Thorac Cardiovasc Surg 1996; 112: 356–63PubMedCrossRef
17.
go back to reference Evans WK, Will BP, Berthelot JM, et al. Diagnostic and therapeutic approaches to lung cancer in Canada and their costs. Br J Cancer 1995; 72: 1270–7PubMedCrossRef Evans WK, Will BP, Berthelot JM, et al. Diagnostic and therapeutic approaches to lung cancer in Canada and their costs. Br J Cancer 1995; 72: 1270–7PubMedCrossRef
18.
go back to reference Chouaid C, Bassinet L, Fuhrman C, et al. Routine use of granulocyte colony-stimulating factor is not cost-effective and does not increase patient comfort in the treatment of small-cell lung cancer: an analysis using a Markov model. J Clin Oncol 1998; 16: 2700–7PubMed Chouaid C, Bassinet L, Fuhrman C, et al. Routine use of granulocyte colony-stimulating factor is not cost-effective and does not increase patient comfort in the treatment of small-cell lung cancer: an analysis using a Markov model. J Clin Oncol 1998; 16: 2700–7PubMed
19.
go back to reference Hillner BE, McDonald MK, Desch CE, et al. Costs of care associated with non-small-cell lung cancer in a commercially insured cohort. J Clin Oncol 1998; 16: 1420–4PubMed Hillner BE, McDonald MK, Desch CE, et al. Costs of care associated with non-small-cell lung cancer in a commercially insured cohort. J Clin Oncol 1998; 16: 1420–4PubMed
20.
go back to reference Goodwin PJ, Sheperd FA. Economic issues in lung cancer: a review. J Clin Oncol 1998; 16: 3900–12PubMed Goodwin PJ, Sheperd FA. Economic issues in lung cancer: a review. J Clin Oncol 1998; 16: 3900–12PubMed
21.
go back to reference Oliver E, Killen J, Kiebert G, et al. Killen J, Kiebert G, Hutton J, Hall R, Higgins B, Bourke S, Paschen B. Treatment pathways, resource use and costs in the management of small cell lung cancer. Thorax 2001; 56: 785–90PubMedCrossRef Oliver E, Killen J, Kiebert G, et al. Killen J, Kiebert G, Hutton J, Hall R, Higgins B, Bourke S, Paschen B. Treatment pathways, resource use and costs in the management of small cell lung cancer. Thorax 2001; 56: 785–90PubMedCrossRef
22.
go back to reference Wolstenholme JL, Whynes DK. The hospital costs of treating lung cancer in the United Kingdom. Br J Cancer 1999; 80: 215–8PubMedCrossRef Wolstenholme JL, Whynes DK. The hospital costs of treating lung cancer in the United Kingdom. Br J Cancer 1999; 80: 215–8PubMedCrossRef
Metadata
Title
Direct Treatment Costs for Patients with Lung Cancer from First Recurrence to Death in France
Authors
Anne-Chantal Brand
Christine Lévy-Piedbois
Pascal Piedbois
Youri Piedbois
Alain Livartovski
Béatrice Le Vu
Jean Trédaniel
François Reboul
Yvelise Brewer
Said Talbi
François Blanchon
Britta Paschen
Isabelle Durand-Zaleski
Publication date
01-06-2003
Publisher
Springer International Publishing
Published in
PharmacoEconomics / Issue 9/2003
Print ISSN: 1170-7690
Electronic ISSN: 1179-2027
DOI
https://doi.org/10.2165/00019053-200321090-00005

Other articles of this Issue 9/2003

PharmacoEconomics 9/2003 Go to the issue