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01-10-2011 | Original Paper

Direct Numerical Simulation of Single Leukocyte Deformation in Microchannel Flow for Disease Diagnosis

Authors: Z. Y. Luo, F. Xu, T. J. Lu, B. F. Bai

Published in: Journal of Medical Systems | Issue 5/2011

Abstract

To better understand the physical mechanism of leukocyte separation via microfluidics, a level set method was employed to analyze the coupled deformation-flow of individual leukocytes in microfluidic parabolic shear blood flow. The results show that: (1) Weber number and viscosity ratio have great effects on the deformation of single leukocyte, (2) difference between the deformation and motion behavior of different subtypes of leukocytes (i.e., granulocytes, lymphocytes, monocytes) was observed, and (3) the existence of a second leukocyte significantly changes the leukocyte deformation and motion. These results shed light on the understanding of the motion and deformation of leukocytes in microchannel flow and provide a theoretical foundation for separating lymphocytes via microfluidics.

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Title: Direct Numerical Simulation of Single Leukocyte Deformation in Microchannel Flow for Disease Diagnosis
Authors: Z. Y. Luo
F. Xu
T. J. Lu
B. F. Bai
Publication date: 01-10-2011
Publisher: Springer US
Published in: Journal of Medical Systems / Issue 5/2011
Print ISSN: 0148-5598
Electronic ISSN: 1573-689X
DOI: https://doi.org/10.1007/s10916-010-9502-3

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Direct Numerical Simulation of Single Leukocyte Deformation in Microchannel Flow for Disease Diagnosis

Abstract

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Abstract

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