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Insights into Imaging

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Open Access 01-06-2013 | Original Article

Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores

Authors: Mehmet Ruhi Onur, Ahmet Kursad Poyraz, Pinar Gundogan Bozdag, Semen Onder, Cem Aygun

Published in: Insights into Imaging | Issue 3/2013

Abstract

Objective

To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH.

Materials and methods

The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained.

Results

Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05).

Conclusion

ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH.

Teaching Points

• In chronic viral hepatitis apparent coefficient values are decreased in the liver

• There is no correlation between ADC values and histopathologic severity of CVH

• DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis

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Title: Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores
Authors: Mehmet Ruhi Onur
Ahmet Kursad Poyraz
Pinar Gundogan Bozdag
Semen Onder
Cem Aygun
Publication date: 01-06-2013
Publisher: Springer Berlin Heidelberg
Published in: Insights into Imaging / Issue 3/2013
Electronic ISSN: 1869-4101
DOI: https://doi.org/10.1007/s13244-013-0252-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores

Abstract

Objective

Materials and methods

Results

Conclusion

Teaching Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

Teaching Points

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