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Pediatric Radiology
Published in: Pediatric Radiology 1/2010

Open Access 01-01-2010 | Minisymposium

Diffusion imaging and tractography of congenital brain malformations

Authors: Michael Wahl, A. James Barkovich, Pratik Mukherjee

Published in: Pediatric Radiology | Issue 1/2010

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Abstract

Diffusion imaging is an MRI modality that measures the microscopic molecular motion of water in order to investigate white matter microstructure. The modality has been used extensively in recent years to investigate the neuroanatomical basis of congenital brain malformations. We review the basic principles of diffusion imaging and of specific techniques, including diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI). We show how DTI and HARDI, and their application to fiber tractography, has elucidated the aberrant connectivity underlying a number of congenital brain malformations. Finally, we discuss potential uses for diffusion imaging of developmental disorders in the clinical and research realms.
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Metadata
Title
Diffusion imaging and tractography of congenital brain malformations
Authors
Michael Wahl
A. James Barkovich
Pratik Mukherjee
Publication date
01-01-2010
Publisher
Springer-Verlag
Published in
Pediatric Radiology / Issue 1/2010
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-009-1448-6

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