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Infectious Agents and Cancer
Published in: Infectious Agents and Cancer 1/2024

Open Access 01-12-2024 | Diffuse Large B-Cell Lymphoma | Research

Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma

Authors: Leihua Fu, Jieni Yu, Zhe Chen, Feidan Gao, Zhijian Zhang, Jiaping Fu, Weiying Feng, Pan Hong, Jing Jin

Published in: Infectious Agents and Cancer | Issue 1/2024

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Abstract

Background

Epidemiological research and systematic meta-analyses indicate a higher risk of B-cell lymphomas in patients with chronic hepatitis C virus (HCV) compared to non-infected individuals. However, the genetic links between HCV and these lymphomas remain under-researched.

Methods

Mendelian randomization analysis was employed to explore the association between chronic hepatitis C (CHC) and B-cell lymphomas as well as chronic lymphocytic leukemia (CLL). Approximate Bayes Factor (ABF) localization analysis was conducted to find shared genetic variants that might connect CHC with B-cell lymphomas and chronic lymphocytic leukemia (CLL). Furthermore, The Variant Effect Predictor (VEP) was utilized to annotate the functional effects of the identified genetic variants.

Results

Mendelian randomization revealed a significant association between CHC and increased diffuse large B cell lymphoma (DLBCL) risk (OR: 1.34; 95% CI: 1.01–1.78; P = 0.0397). Subsequent colocalization analysis pinpointed two noteworthy variants, rs17208853 (chr6:32408583) and rs482759 (chr6:32227240) between these two traits. The annotation of these variants through the VEP revealed their respective associations with the butyrophilin-like protein 2 (BTNL2) and notch receptor 4 (NOTCH4) genes, along with the long non-coding RNA (lncRNA) TSBP1-AS1.

Conclusion

This research provides a refined genetic understanding of the CHC-DLBCL connection, opening avenues for targeted therapeutic research and intervention.
Appendix
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Metadata
Title
Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma
Authors
Leihua Fu
Jieni Yu
Zhe Chen
Feidan Gao
Zhijian Zhang
Jiaping Fu
Weiying Feng
Pan Hong
Jing Jin
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Infectious Agents and Cancer / Issue 1/2024
Electronic ISSN: 1750-9378
DOI
https://doi.org/10.1186/s13027-024-00577-4

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