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Indian Journal of Hematology and Blood Transfusion

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01-09-2014 | Case Report

Diffuse Large B Cell Lymphoma in Wiskott-Aldrich Syndrome: A Case Report and Review of Literature

Authors: Jayastu Senapati, Anup J. Devasia, Sachin David, Marie Therese Manipadam, Sheila Nair, Giridhara R. Jayandharan, Biju George

Published in: Indian Journal of Hematology and Blood Transfusion | Special Issue 1/2014

Abstract

Wiskott-Aldrich syndrome (WAS) is an X linked rare primary immunodeficiency syndrome with an increased propensity for infection, autoimmunity and malignancy. Here we report a male child, who was diagnosed with WAS at 1 year of age following evaluation for symptomatic thrombocytopenia and eczematous skin lesions. He presented later with lymphadenopathy, which was consistent with diffuse large B cell lymphoma on histopathology. He received 6 cycles of R-CHOP chemotherapy for the same and is presently in remission after 6 months. We review the major publications of lymphoma in WAS and discuss the pathological findings, treatment and prognosis of lymphoma in WAS.

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Title: Diffuse Large B Cell Lymphoma in Wiskott-Aldrich Syndrome: A Case Report and Review of Literature
Authors: Jayastu Senapati
Anup J. Devasia
Sachin David
Marie Therese Manipadam
Sheila Nair
Giridhara R. Jayandharan
Biju George
Publication date: 01-09-2014
Publisher: Springer India
Published in: Indian Journal of Hematology and Blood Transfusion / Issue Special Issue 1/2014
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-014-0377-1

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