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01-04-2014 | Case Report

Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma: a case report of an elderly man

Authors: Kenta Takahashi, Masumi Tsuda, Hiromi Kanno, Junichi Murata, Roshan Mahabir, Yusuke Ishida, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Kazuo Nagashima, Shinya Tanaka

Published in: Brain Tumor Pathology | Issue 2/2014

Abstract

Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic carcinoma should be carefully discriminated. Some cases are difficult to differentiate from anaplastic oligodendroglioma. In this report, we present a case of small cell glioblastoma of an elderly man. The lack of IDH1/2 mutation was confirmed by immunohistochemistry and direct sequencing. Fluorescence in situ hybridization revealed the lower rates of chromosome 1p and 19q deletion. Microsatellite analysis disclosed partial 10q alteration near the PTEN locus. Not only morphological and immunohistochemical examinations, but also cytogenetical investigations for IDH1/2 mutation, 1p/19q loss, and PTEN alteration, are strongly supportive methods for the differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma.

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Title: Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma: a case report of an elderly man
Authors: Kenta Takahashi
Masumi Tsuda
Hiromi Kanno
Junichi Murata
Roshan Mahabir
Yusuke Ishida
Taichi Kimura
Mishie Tanino
Hiroshi Nishihara
Kazuo Nagashima
Shinya Tanaka
Publication date: 01-04-2014
Publisher: Springer Japan
Published in: Brain Tumor Pathology / Issue 2/2014
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-013-0158-9

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Differential diagnosis of small cell glioblastoma and anaplastic oligodendroglioma: a case report of an elderly man

Abstract

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