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Open Access 01-12-2020 | Research article

Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant

Authors: Peicong Ge, Qian Zhang, Xun Ye, Xingju Liu, Xiaofeng Deng, Jia Wang, Rong Wang, Yan Zhang, Dong Zhang, Jizong Zhao

Published in: BMC Neurology | Issue 1/2020

Abstract

Background

The aim of this study was to investigate the hemorrhgic sites and collateral vessels in hemorrhagic MMD with the p.R4810K variant.

Methods

Hemorrhage sites were classified as either anterior or posterior. Collateral vessels were classified into three subtypes according to origin: lenticulostriate anastomosis, thalamic anastomosis, and choroidal anastomosis. Hemorrhage sites and collateral vessels were compared between patients with wild-type p.R4810K variant (GG) and patients with heterozygous p.R4810K variant (GA) after 1:1 propensity score matching.

Results

A total of 130 hemorrhagic MMD patients were included in present study, 21 pairs (42 hemorrhagic hemispheres) were obtained after 1:1 propensity score. In GA group, 16 hemispheres (76.2%) presented anterior hemorrhage, and 5 hemispheres (23.8%) presented with posterior hemorrhage. In GG group, 13 hemispheres (61.9%) presented anterior hemorrhage, and 8 hemispheres (38.1%) presented with posterior hemorrhage. No significant differences were found in hemorrhagic sites between two matched groups (P > 0.05). Of 21 hemispheres in GA group, 10 (47.6%) exhibited lenticulostriate anastomosis, 6 (28.6%) thalamic anastomosis, and 6 (28.6%) choroidal anastomosis. Of 21 hemispheres in GG group, 3 (14.3%) exhibited lenticulostriate anastomosis, 5 (23.8%) thalamic anastomosis, and 9 (42.9%) choroidal anastomosis. There was significant difference in lenticulostriate anastomosis between two matched groups (P = 0.045). After adjustment the age, sex, and PCA involvement, we found that lenticulostriate anastomosis was associated with p.R4810K variant (OR, 5.995; 95% CI, 1.296–27.737; P = 0.022).

Conclusion

Lenticulostriate anastomosis might be associated with p.R4810K variant. Whereas hemorrhagic sites, thalamic anastomosis, and choroidal anastomosis might not be associted withp.R4810K variant.

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Title: Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant
Authors: Peicong Ge
Qian Zhang
Xun Ye
Xingju Liu
Xiaofeng Deng
Jia Wang
Rong Wang
Yan Zhang
Dong Zhang
Jizong Zhao
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2020
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-020-01884-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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