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Oral and Maxillofacial Surgery

Published in:

01-03-2018 | Original Article

Differences between osteoradionecrosis and medication-related osteonecrosis of the jaw

Authors: Masaya Akashi, Satoshi Wanifuchi, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Shungo Furudoi, Takahide Komori

Published in: Oral and Maxillofacial Surgery | Issue 1/2018

Abstract

Purpose

The appearance of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) is similar, but clinically important differences between ORN and MRONJ exist. The aim of this study was to compare the clinical data between ORN and MRONJ and to reveal the critical differences between these diseases.

Methods

We retrospectively reviewed the epidemiological data, clinical findings, and treatment in 27 ORN and 61 MRONJ patients. Radiographic signs before the initiation of treatment were also assessed.

Results

The median age (P = 0.0474) and the ratio of female to male patients (P < 0.0001) were significantly higher in MRONJ patients. There were significantly more MRONJ patients who reported a history of pain when compared with ORN patients (P = 0.0263). As an aetiological factor, tooth extraction was significantly more relevant to MRONJ than ORN (P = 0.0352). When assessing the radiographic signs on computed tomographic images, periosteal reaction was found only in MRONJ patients (P = 0.0158). Minimal debridement was performed significantly more frequently for MRONJ (P = 0.0093), and by contrast, surgical resection was performed more frequently for ORN (P = 0.0002).

Conclusions

Understanding the clinical and underlying pathological differences between ORN and MRONJ probably contributes to the selection of appropriate treatment for each patient.

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Title: Differences between osteoradionecrosis and medication-related osteonecrosis of the jaw
Authors: Masaya Akashi
Satoshi Wanifuchi
Eiji Iwata
Daisuke Takeda
Junya Kusumoto
Shungo Furudoi
Takahide Komori
Publication date: 01-03-2018
Publisher: Springer Berlin Heidelberg
Published in: Oral and Maxillofacial Surgery / Issue 1/2018
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI: https://doi.org/10.1007/s10006-017-0667-5

At a glance: The STEP trials

Springer Medicine

Differences between osteoradionecrosis and medication-related osteonecrosis of the jaw

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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