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Published in: European Journal of Medical Research 1/2023

Open Access 01-12-2023 | Research

Dietary fatty acid patterns and risk of metabolic syndrome: Tehran lipid and glucose study

Authors: Parvin Mirmiran, Zahra Gaeini, Zahra Feizy, Fereidoun Azizi

Published in: European Journal of Medical Research | Issue 1/2023

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Abstract

Background

The association between individual dietary fatty acids (FAs) and risk of metabolic syndrome (MetS) has been investigated in previous studies. However, synergistic or additive effects of multiple FA have received less attention. Hence, we aimed to determine the major dietary FA patterns and evaluate the association between FA patterns and risk of MetS.

Methods

Dietary intakes of 1713 MetS-free adults who participated in the third phase of the Tehran Lipid and Glucose Study (TLGS) were assessed using a validated 168-items food frequency questionnaire. FA patterns were obtained by principal component analysis (PCA). Adjusted Hazard Ratios (HRs) and 95% confidence intervals (CIs) were calculated for the association of MetS incident with the extracted FA patterns.

Results

Four major FA patterns were identified through PCA of the 24 FAs consumed: “short- and medium-chain saturated fatty acid (SFA) pattern”, “long-chain FA pattern”, “omega-3 PUFA pattern”, and “long-chain SFA pattern”. There was no significant association between dietary FA patterns and risk of MetS incidence.

Conclusions

We found no significant association between FA patterns and risk of MetS. More prospective cohort studies and clinical trials are needed to clarify the issue.
Literature
2.
go back to reference Um Y-J, Oh S-W, Lee C-M, Kwon H-T, Joh H-K, Kim Y-J, et al. Dietary fat intake and the risk of metabolic syndrome in Korean adults. Korean J Fam Med. 2015;36(5):245–52.CrossRefPubMedPubMedCentral Um Y-J, Oh S-W, Lee C-M, Kwon H-T, Joh H-K, Kim Y-J, et al. Dietary fat intake and the risk of metabolic syndrome in Korean adults. Korean J Fam Med. 2015;36(5):245–52.CrossRefPubMedPubMedCentral
3.
go back to reference Hekmatdoost A, Mirmiran P, Hosseini-Esfahani F, Azizi F. Dietary fatty acid composition and metabolic syndrome in Tehranian adults. Nutrition. 2011;27(10):1002–7.CrossRefPubMed Hekmatdoost A, Mirmiran P, Hosseini-Esfahani F, Azizi F. Dietary fatty acid composition and metabolic syndrome in Tehranian adults. Nutrition. 2011;27(10):1002–7.CrossRefPubMed
4.
go back to reference Julibert A, Bibiloni MDM, Bouzas C, Alonso-Gómez ÁM, Babio N, Becerra-Tomás N, et al. Total and subtypes of dietary fat intake and its association with components of the metabolic syndrome in a mediterranean population at high cardiovascular risk. Nutrition. 2019. https://doi.org/10.3390/nu11081901.CrossRef Julibert A, Bibiloni MDM, Bouzas C, Alonso-Gómez ÁM, Babio N, Becerra-Tomás N, et al. Total and subtypes of dietary fat intake and its association with components of the metabolic syndrome in a mediterranean population at high cardiovascular risk. Nutrition. 2019. https://​doi.​org/​10.​3390/​nu11081901.CrossRef
5.
go back to reference Noel SE, Newby PK, Ordovas JM, Tucker KL. Adherence to an (n-3) fatty acid/fish intake pattern is inversely associated with metabolic syndrome among Puerto Rican adults in the Greater Boston area. J Nutr. 2010;140(10):1846–54.CrossRefPubMedPubMedCentral Noel SE, Newby PK, Ordovas JM, Tucker KL. Adherence to an (n-3) fatty acid/fish intake pattern is inversely associated with metabolic syndrome among Puerto Rican adults in the Greater Boston area. J Nutr. 2010;140(10):1846–54.CrossRefPubMedPubMedCentral
6.
go back to reference Choi E, Ahn S, Joung H. Association of dietary fatty acid consumption patterns with risk of hyper-LDL cholesterolemiain Korean adults. Nutrients. 2020;12(5):1412.CrossRefPubMedPubMedCentral Choi E, Ahn S, Joung H. Association of dietary fatty acid consumption patterns with risk of hyper-LDL cholesterolemiain Korean adults. Nutrients. 2020;12(5):1412.CrossRefPubMedPubMedCentral
7.
go back to reference Warensjö E, Sundström J, Lind L, Vessby B. Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men. Am J Clin Nutr. 2006;84(2):442–8.CrossRefPubMed Warensjö E, Sundström J, Lind L, Vessby B. Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men. Am J Clin Nutr. 2006;84(2):442–8.CrossRefPubMed
8.
go back to reference Azizi F, Zadeh-Vakili A, Takyar M. Review of rationale, design, and initial findings: Tehran lipid and glucose study. Int J Endocrinol Metab. 2018;16(4):84777. Azizi F, Zadeh-Vakili A, Takyar M. Review of rationale, design, and initial findings: Tehran lipid and glucose study. Int J Endocrinol Metab. 2018;16(4):84777.
9.
go back to reference Hosseini-Esfahani F, Jessri M, Mirmiran P, Bastan S, Azizi F. Adherence to dietary recommendations and risk of metabolic syndrome: Tehran lipid and glucose study. Metabolism. 2010;59(12):1833–42.CrossRefPubMed Hosseini-Esfahani F, Jessri M, Mirmiran P, Bastan S, Azizi F. Adherence to dietary recommendations and risk of metabolic syndrome: Tehran lipid and glucose study. Metabolism. 2010;59(12):1833–42.CrossRefPubMed
10.
go back to reference Askari S, Asghari G, Ghanbarian A, Khazan M, Alamdari S, Azizi F. Seasonal variations of blood pressure in adults: Tehran lipid and glucose study. Arch Iran Med. 2014;17(6):441.PubMed Askari S, Asghari G, Ghanbarian A, Khazan M, Alamdari S, Azizi F. Seasonal variations of blood pressure in adults: Tehran lipid and glucose study. Arch Iran Med. 2014;17(6):441.PubMed
11.
go back to reference Momenan AA, Delshad M, Sarbazi N, Rezaei Ghaleh N, Ghanbarian A, Azizi F. Reliability and validity of the modifiable activity questionnaire (MAQ) in an Iranian urban adult population. Arch Iran Med. 2012;15(5):279–82.PubMed Momenan AA, Delshad M, Sarbazi N, Rezaei Ghaleh N, Ghanbarian A, Azizi F. Reliability and validity of the modifiable activity questionnaire (MAQ) in an Iranian urban adult population. Arch Iran Med. 2012;15(5):279–82.PubMed
12.
go back to reference Ainsworth BE, Haskell WL, Leon AS, Jacobs DR Jr, Montoye HJ, Sallis JF, et al. Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc. 1993;25(1):71–80.CrossRefPubMed Ainsworth BE, Haskell WL, Leon AS, Jacobs DR Jr, Montoye HJ, Sallis JF, et al. Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc. 1993;25(1):71–80.CrossRefPubMed
13.
go back to reference Mirmiran P, Esfahani FH, Mehrabi Y, Hedayati M, Azizi F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr. 2010;13(5):654–62.CrossRefPubMed Mirmiran P, Esfahani FH, Mehrabi Y, Hedayati M, Azizi F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr. 2010;13(5):654–62.CrossRefPubMed
14.
go back to reference Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation. 2005;112(17):2735–52.CrossRefPubMed Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation. 2005;112(17):2735–52.CrossRefPubMed
15.
go back to reference Azizi F, Hadaegh F, Khalili D, Esteghamati A, Hosseinpanah F, Delavari A, et al. Appropriate definition of metabolic syndrome among Iranian adults: report of the Iranian national committee of obesity. Arch Iran Med. 2010;13(5):426–8.PubMed Azizi F, Hadaegh F, Khalili D, Esteghamati A, Hosseinpanah F, Delavari A, et al. Appropriate definition of metabolic syndrome among Iranian adults: report of the Iranian national committee of obesity. Arch Iran Med. 2010;13(5):426–8.PubMed
16.
go back to reference Lichtenstein AH, Kennedy E, Barrier P, Danford D, Ernst ND, Grundy SM, et al. Dietary fat consumption and health. Nutr Rev. 1998;56(5 Pt 2):S3-19.PubMed Lichtenstein AH, Kennedy E, Barrier P, Danford D, Ernst ND, Grundy SM, et al. Dietary fat consumption and health. Nutr Rev. 1998;56(5 Pt 2):S3-19.PubMed
17.
go back to reference Daumerie CM, Woollett LA, Dietschy JM. Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools. Proc Natl Acad Sci USA. 1992;89(22):10797–801.CrossRefPubMedPubMedCentral Daumerie CM, Woollett LA, Dietschy JM. Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools. Proc Natl Acad Sci USA. 1992;89(22):10797–801.CrossRefPubMedPubMedCentral
18.
go back to reference Fernandez ML, West KL. Mechanisms by which dietary fatty acids modulate plasma lipids. J Nutr. 2005;135(9):2075–8.CrossRefPubMed Fernandez ML, West KL. Mechanisms by which dietary fatty acids modulate plasma lipids. J Nutr. 2005;135(9):2075–8.CrossRefPubMed
19.
go back to reference Mustad VA, Ellsworth JL, Cooper AD, Kris-Etherton PM, Etherton TD. Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs. J Lipid Res. 1996;37(11):2310–23.CrossRefPubMed Mustad VA, Ellsworth JL, Cooper AD, Kris-Etherton PM, Etherton TD. Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs. J Lipid Res. 1996;37(11):2310–23.CrossRefPubMed
20.
go back to reference DuBroff R, de Lorgeril M. Fat or fiction: the diet-heart hypothesis. BMJ Evidence-Based Med. 2021;26(1):3–7.CrossRef DuBroff R, de Lorgeril M. Fat or fiction: the diet-heart hypothesis. BMJ Evidence-Based Med. 2021;26(1):3–7.CrossRef
21.
go back to reference Hooper L, Martin N, Jimoh OF, Kirk C, Foster E, Abdelhamid AS. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database Syst Rev. 2020;8(8):011737. Hooper L, Martin N, Jimoh OF, Kirk C, Foster E, Abdelhamid AS. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database Syst Rev. 2020;8(8):011737.
22.
go back to reference Chiu S, Williams PT, Krauss RM. Effects of a very high saturated fat diet on LDL particles in adults with atherogenic dyslipidemia: a randomized controlled trial. PLoS ONE. 2017;12(2):0170664.CrossRef Chiu S, Williams PT, Krauss RM. Effects of a very high saturated fat diet on LDL particles in adults with atherogenic dyslipidemia: a randomized controlled trial. PLoS ONE. 2017;12(2):0170664.CrossRef
24.
go back to reference Astrup A, Magkos F, Bier Dennis M, Brenna JT, De Oliveira Otto Marcia C, Hill James O, et al. Saturated fats and health: a reassessment and proposal for food-based recommendations. J Am College Cardiol. 2020;76(7):844–57.CrossRef Astrup A, Magkos F, Bier Dennis M, Brenna JT, De Oliveira Otto Marcia C, Hill James O, et al. Saturated fats and health: a reassessment and proposal for food-based recommendations. J Am College Cardiol. 2020;76(7):844–57.CrossRef
25.
go back to reference Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, et al. Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans. Am J Clin Nutr. 2014;99(3):436–45.CrossRefPubMedPubMedCentral Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, et al. Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans. Am J Clin Nutr. 2014;99(3):436–45.CrossRefPubMedPubMedCentral
27.
go back to reference Unger AL, Torres-Gonzalez M, Kraft J. Dairy fat consumption and the risk of metabolic syndrome: an examination of the saturated fatty acids in dairy. Nutrients. 2019;11(9):2200.CrossRefPubMedPubMedCentral Unger AL, Torres-Gonzalez M, Kraft J. Dairy fat consumption and the risk of metabolic syndrome: an examination of the saturated fatty acids in dairy. Nutrients. 2019;11(9):2200.CrossRefPubMedPubMedCentral
28.
go back to reference Nikooei P, Hosseinzadeh-Attar MJ, Asghari S, Norouzy A, Yaseri M, Vasheghani-Farahani A. Effects of virgin coconut oil consumption on metabolic syndrome components and asymmetric dimethylarginine: a randomized controlled clinical trial. Nutr Metab Cardiovasc Dis. 2021;31(3):939–49.CrossRefPubMed Nikooei P, Hosseinzadeh-Attar MJ, Asghari S, Norouzy A, Yaseri M, Vasheghani-Farahani A. Effects of virgin coconut oil consumption on metabolic syndrome components and asymmetric dimethylarginine: a randomized controlled clinical trial. Nutr Metab Cardiovasc Dis. 2021;31(3):939–49.CrossRefPubMed
29.
go back to reference Júnior FAO, Ruiz CR, de Oliveira Y, Barros MAV, Silva AS, Santos MSB, et al. Coconut oil supplementation does not affect blood pressure variability and oxidative stress: a placebo-controlled clinical study in stage-1 hypertensive patients. Nutrients. 2021;13(3):798.CrossRefPubMedPubMedCentral Júnior FAO, Ruiz CR, de Oliveira Y, Barros MAV, Silva AS, Santos MSB, et al. Coconut oil supplementation does not affect blood pressure variability and oxidative stress: a placebo-controlled clinical study in stage-1 hypertensive patients. Nutrients. 2021;13(3):798.CrossRefPubMedPubMedCentral
30.
go back to reference Wang L, Manson JE, Forman JP, Gaziano JM, Buring JE, Sesso HD. Dietary fatty acids and the risk of hypertension in middle-aged and older women. Hypertension. 2010;56(4):598–604.CrossRefPubMed Wang L, Manson JE, Forman JP, Gaziano JM, Buring JE, Sesso HD. Dietary fatty acids and the risk of hypertension in middle-aged and older women. Hypertension. 2010;56(4):598–604.CrossRefPubMed
31.
go back to reference Nakamura H, Tsujiguchi H, Kambayashi Y, Hara A, Miyagi S, Yamada Y, et al. Relationship between saturated fatty acid intake and hypertension and oxidative stress. Nutrition. 2019;61:8–15.CrossRefPubMed Nakamura H, Tsujiguchi H, Kambayashi Y, Hara A, Miyagi S, Yamada Y, et al. Relationship between saturated fatty acid intake and hypertension and oxidative stress. Nutrition. 2019;61:8–15.CrossRefPubMed
32.
go back to reference Suburu J, Gu Z, Chen H, Chen W, Zhang H, Chen YQ. Fatty acid metabolism: implications for diet, genetic variation, and disease. Food Biosci. 2013;4:1–12.CrossRefPubMedPubMedCentral Suburu J, Gu Z, Chen H, Chen W, Zhang H, Chen YQ. Fatty acid metabolism: implications for diet, genetic variation, and disease. Food Biosci. 2013;4:1–12.CrossRefPubMedPubMedCentral
34.
go back to reference Kim Y-S, Xun P, He K. Fish consumption, long-chain omega-3 polyunsaturated fatty acid intake and risk of metabolic syndrome: a meta-analysis. Nutrients. 2015;7(4):2085–100.CrossRefPubMedPubMedCentral Kim Y-S, Xun P, He K. Fish consumption, long-chain omega-3 polyunsaturated fatty acid intake and risk of metabolic syndrome: a meta-analysis. Nutrients. 2015;7(4):2085–100.CrossRefPubMedPubMedCentral
35.
go back to reference Shang X, Scott D, Hodge A, English DR, Giles GG, Ebeling PR, et al. Dietary protein from different food sources, incident metabolic syndrome and changes in its components: an 11-year longitudinal study in healthy community-dwelling adults. Clin Nutr. 2017;36(6):1540–8.CrossRefPubMed Shang X, Scott D, Hodge A, English DR, Giles GG, Ebeling PR, et al. Dietary protein from different food sources, incident metabolic syndrome and changes in its components: an 11-year longitudinal study in healthy community-dwelling adults. Clin Nutr. 2017;36(6):1540–8.CrossRefPubMed
36.
go back to reference Shin A, Lim S-Y, Sung J, Shin H-R, Kim J. Dietary intake, eating habits, and metabolic syndrome in Korean men. J Am Diet Assoc. 2009;109(4):633–40.CrossRefPubMed Shin A, Lim S-Y, Sung J, Shin H-R, Kim J. Dietary intake, eating habits, and metabolic syndrome in Korean men. J Am Diet Assoc. 2009;109(4):633–40.CrossRefPubMed
37.
go back to reference Baik I, Abbott RD, Curb JD, Shin C. Intake of fish and n-3 fatty acids and future risk of metabolic syndrome. J Am Diet Assoc. 2010;110(7):1018–26.CrossRefPubMed Baik I, Abbott RD, Curb JD, Shin C. Intake of fish and n-3 fatty acids and future risk of metabolic syndrome. J Am Diet Assoc. 2010;110(7):1018–26.CrossRefPubMed
38.
go back to reference Kim Y-S, Xun P, Iribarren C, Van Horn L, Steffen L, Daviglus ML, et al. Intake of fish and long-chain omega-3 polyunsaturated fatty acids and incidence of metabolic syndrome among American young adults: a 25-year follow-up study. Eur J Nutr. 2016;55(4):1707–16.CrossRefPubMedPubMedCentral Kim Y-S, Xun P, Iribarren C, Van Horn L, Steffen L, Daviglus ML, et al. Intake of fish and long-chain omega-3 polyunsaturated fatty acids and incidence of metabolic syndrome among American young adults: a 25-year follow-up study. Eur J Nutr. 2016;55(4):1707–16.CrossRefPubMedPubMedCentral
Metadata
Title
Dietary fatty acid patterns and risk of metabolic syndrome: Tehran lipid and glucose study
Authors
Parvin Mirmiran
Zahra Gaeini
Zahra Feizy
Fereidoun Azizi
Publication date
01-12-2023
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-023-01348-4

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