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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 5/2012

01-05-2012 | Gastrointestinal Oncology

Diagnostic Value of Sentinel Lymph Node Biopsy in Gastric Cancer: A Meta-Analysis

Authors: Zhen Wang, MD, Zhi-Yong Dong, MD, Jun-Qiang Chen, PhD, Jin-Lu Liu, MD

Published in: Annals of Surgical Oncology | Issue 5/2012

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Abstract

Background

The possible application and validity of the sentinel lymph node (SLN) concept in gastric cancer (GC) is still debated. A systematic review to evaluate the diagnostic value of SLN biopsy (SLNB) in GC is urgently needed.

Methods

A systematic review of relevant literatures was performed in PubMed, Embase, and The Cochrane Library. A random-effect model was used to pool the data, and subgroup analysis was used to explain the heterogeneities.

Results

A total of 38 included studies (2,128 patients) were included. The pooled SLN identification rate, sensitivity, negative predictive value, and accuracy were 93.7% (95% confidence interval [95% CI]: 91.1–95.6%), 76.9% (95% CI: 71.6–81.4%), 90.3% (95% CI: 86.9–92.9%), and 92.0% (95% CI: 89.9–93.7%), respectively. Subgroup analysis showed that early T stage, combined tracers, submucosal injection method, conventional open surgery, and usage of immunohistochemistry were associated with higher SLN identification rate and sensitivity.

Conclusions

SLNB in GC is technically feasible with an acceptable sensitivity. However, further studies are needed to confirm the best procedure and standard criteria.
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Metadata
Title
Diagnostic Value of Sentinel Lymph Node Biopsy in Gastric Cancer: A Meta-Analysis
Authors
Zhen Wang, MD
Zhi-Yong Dong, MD
Jun-Qiang Chen, PhD
Jin-Lu Liu, MD
Publication date
01-05-2012
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 5/2012
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-011-2124-2

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