Skip to main content
Top
Published in: Indian Journal of Hematology and Blood Transfusion 1/2018

01-01-2018 | Correspondence

Diagnostic and Prognostic Value of Serum Thymidine Kinase 1 in Cancer Patients

Authors: Yantao Li, Rongna Wei, Shilin Song

Published in: Indian Journal of Hematology and Blood Transfusion | Issue 1/2018

Login to get access

Excerpt

Once tumorigenic factors induce abnormal cells’ growth, they grow indefinitely without physiological regulations [13]. Studies found serum thymidine kinase 1 (TK1) level of cancer patients deviates to a certain extent from normal [4, 5]. It is possible that serum TK1 level can be used in cancers’ diagnosis and prognosis. Our study aimed to explore related viewpoint via a clinical controlled trial. …
Literature
1.
go back to reference Kamran SC, Howard SA, Shinagare AB et al (2013) Malignant peripheral nerve sheath tumors: prognostic impact of rhabdomyoblastic differentiation (malignant triton tumors), neurofibromatosis 1 status and location. Eur J Surg Oncol 39(1):46–52CrossRefPubMed Kamran SC, Howard SA, Shinagare AB et al (2013) Malignant peripheral nerve sheath tumors: prognostic impact of rhabdomyoblastic differentiation (malignant triton tumors), neurofibromatosis 1 status and location. Eur J Surg Oncol 39(1):46–52CrossRefPubMed
2.
go back to reference Xie L, Fan M, Sheets NC et al (2012) The use of radiation therapy appears to improve outcome in patients with malignant primary tracheal tumors: a SEER-based analysis. Int J Radiat Oncol Biol Phys 84(2):464–470CrossRefPubMed Xie L, Fan M, Sheets NC et al (2012) The use of radiation therapy appears to improve outcome in patients with malignant primary tracheal tumors: a SEER-based analysis. Int J Radiat Oncol Biol Phys 84(2):464–470CrossRefPubMed
3.
go back to reference Benz MR, Czernin J, Allen-Auerbach MS et al (2012) 3′-deoxy-3′-[18F] fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: a pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response. Cancer 118(12):3135–3144CrossRefPubMed Benz MR, Czernin J, Allen-Auerbach MS et al (2012) 3′-deoxy-3′-[18F] fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: a pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response. Cancer 118(12):3135–3144CrossRefPubMed
4.
go back to reference Bolayirli M, Papila C, Korkmaz GG et al (2013) Serum thymidine kinase 1 activity in solid tumor (breast and colorectal cancer) patients treated with adjuvant chemotherapy. J Clin Lab Anal 27(3):220–226CrossRefPubMed Bolayirli M, Papila C, Korkmaz GG et al (2013) Serum thymidine kinase 1 activity in solid tumor (breast and colorectal cancer) patients treated with adjuvant chemotherapy. J Clin Lab Anal 27(3):220–226CrossRefPubMed
5.
go back to reference Nisman B, Allweis T, Kadouri L et al (2013) Comparison of diagnostic and prognostic performance of two assays measuring thymidine kinase 1 activity in serum of breast cancer patients. Clin Chem Lab Med: CCLM 51(2):439–447CrossRefPubMed Nisman B, Allweis T, Kadouri L et al (2013) Comparison of diagnostic and prognostic performance of two assays measuring thymidine kinase 1 activity in serum of breast cancer patients. Clin Chem Lab Med: CCLM 51(2):439–447CrossRefPubMed
6.
go back to reference Zhou J, Zhang W, Yang W, Wang X, Li F (2015) Effect of S-1 on serum TK1, VEGF, IGF-1 and tumor biomarkers, estrgen levels in patients with advanced breast cancer. Chin J Biochem Pharm 35(8):69–71 Zhou J, Zhang W, Yang W, Wang X, Li F (2015) Effect of S-1 on serum TK1, VEGF, IGF-1 and tumor biomarkers, estrgen levels in patients with advanced breast cancer. Chin J Biochem Pharm 35(8):69–71
7.
go back to reference Xiaojun T, Guiming C, Xiaohong F, Yefu S (2012) Clinical value of combined detection of serum TK1, TPS and CA15-3 in diagnosis of breast cancer. Int J Lab Med 33(16):1943–1944, 1946 Xiaojun T, Guiming C, Xiaohong F, Yefu S (2012) Clinical value of combined detection of serum TK1, TPS and CA15-3 in diagnosis of breast cancer. Int J Lab Med 33(16):1943–1944, 1946
8.
go back to reference Liu M, Deng Y, Liu P (2012) Value of joint detection of serum SCC-Ag, VEGF, IGF-II and TK1 in the diagnosis of early stage cervical cancer. Hainan Med J 23(13):91–93 Liu M, Deng Y, Liu P (2012) Value of joint detection of serum SCC-Ag, VEGF, IGF-II and TK1 in the diagnosis of early stage cervical cancer. Hainan Med J 23(13):91–93
9.
go back to reference Huang MY, Wu CH, Huang CM et al (2013) DPYD, TYMS, TYMP, TK1, and TK2 genetic expressions as response markers in locally advanced rectal cancer patients treated with fluoropyrimidine-based chemoradiotherapy. Biomed Res Int 2013. doi:10.1155/2013/931028 Huang MY, Wu CH, Huang CM et al (2013) DPYD, TYMS, TYMP, TK1, and TK2 genetic expressions as response markers in locally advanced rectal cancer patients treated with fluoropyrimidine-based chemoradiotherapy. Biomed Res Int 2013. doi:10.​1155/​2013/​931028
10.
go back to reference Schelhaas S, Wachsmuth L, Viel T et al (2014) Variability of proliferation and diffusion in different lung cancer models as measured by 3′-deoxy-3′-18F-fluorothymidine PET and diffusion-weighted MR imaging. J Nucl Med 55(6):983–988CrossRefPubMed Schelhaas S, Wachsmuth L, Viel T et al (2014) Variability of proliferation and diffusion in different lung cancer models as measured by 3′-deoxy-3′-18F-fluorothymidine PET and diffusion-weighted MR imaging. J Nucl Med 55(6):983–988CrossRefPubMed
Metadata
Title
Diagnostic and Prognostic Value of Serum Thymidine Kinase 1 in Cancer Patients
Authors
Yantao Li
Rongna Wei
Shilin Song
Publication date
01-01-2018
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue 1/2018
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-017-0812-1

Other articles of this Issue 1/2018

Indian Journal of Hematology and Blood Transfusion 1/2018 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine