Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
The International Journal of Cardiovascular Imaging
Published in: The International Journal of Cardiovascular Imaging 5/2008

01-06-2008 | Original Paper

Diagnostic accuracy of myocardial perfusion imaging with single photon emission computed tomography and positron emission tomography: a comparison with coronary angiography

Authors: Lars Husmann, Mischa Wiegand, Ines Valenta, Oliver Gaemperli, Tiziano Schepis, Patrick T. Siegrist, Mehdi Namdar, Christophe A. Wyss, Hatem Alkadhi, Philipp A. Kaufmann

Published in: The International Journal of Cardiovascular Imaging | Issue 5/2008

Login to get access

Abstract

Objective The aim of this study was to compare the diagnostic accuracy of myocardial perfusion imaging (MPI) by positron emission tomography (PET) with the diagnostic accuracy of MPI by single photon emission computed tomography (SPECT) in two comparable patient cohorts, using coronary angiography (CA) as the standard of reference. Methods A “SPECT-group” of 80 patients (15 female, 65 male; mean age 60 ± 9 years) and a “PET-group” of 70 patients (14 female, 56 male; mean age 57 ± 10 years) underwent a one day stress/rest examination either with attenuation-corrected 13N-ammonia PET or attenuation-corrected 201TlCl SPECT or 99mTc-hexakis-methoxy-isobutyl-isonitril (MIBI) SPECT. PET and SPECT results were semiquantitatively graded using a 6-segment heart model. All patients underwent CA, and stenoses were graded as a diameter reduction ≥50%. Results Coronary findings between both groups did not significantly differ at CA. For the SPECT-group overall sensitivity and specificity for localisation of stenoses was 77% and 84%. Respective values for the PET-group were 97% and 84%. The specificity of MPI by SPECT in the detection of ischemia was 74% and 91% for MPI by PET. The diagnostic accuracy of MPI improves when the individual coronary dominance and previous coronary revascularisations are taken into account. Conclusion MPI by 13N-ammonia PET is more sensitive in the detection and localisation of coronary stenoses, and more specific in the detection of ischemia than MPI by 201TlCl/99mMIBI SPECT.
Literature
1.
Tamaki N, Yonekura Y, Senda M et al (1988) Value and limitation of stress thallium-201 single photon emission computed tomography: comparison with nitrogen-13 ammonia positron tomography. J Nucl Med 29:1181–1188PubMed
2.
Di Carli MF, Hachamovitch R (2007) New technology for noninvasive evaluation of coronary artery disease. Circulation 115:1464–1480PubMedCrossRef
3.
Klocke FJ, Baird MG, Lorell BH et al (2003) ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging). J Am Coll Cardiol 42:1318–1333PubMedCrossRef
4.
Slart RH, Bax JJ, van Veldhuisen DJ, van der Wall EE, Dierckx RA, Jager PL (2006) Imaging techniques in nuclear cardiology for the assessment of myocardial viability. Int J Cardiovasc Imaging 22:63–80PubMedCrossRef
5.
Stewart RE, Schwaiger M, Molina E et al (1991) Comparison of rubidium-82 positron emission tomography and thallium-201 SPECT imaging for detection of coronary artery disease. Am J Cardiol 67:1303–1310PubMedCrossRef
6.
Go RT, Marwick TH, MacIntyre WJ et al (1990) A prospective comparison of rubidium-82 PET and thallium-201 SPECT myocardial perfusion imaging utilizing a single dipyridamole stress in the diagnosis of coronary artery disease. J Nucl Med 31:1899–1905PubMed
7.
Marwick TH, Go RT, MacIntyre WJ, Saha GB, Underwood DA (1991) Myocardial perfusion imaging with positron emission tomography and single photon emission computed tomography: frequency and causes of disparate results. Eur Heart J 12:1064–1069PubMed
8.
Bateman TM, Heller GV, McGhie AI et al (2006) Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: comparison with ECG-gated Tc-99 m sestamibi SPECT. J Nucl Cardiol 13:24–33PubMedCrossRef
9.
Di Carli MF, Hachamovitch R (2006) Should PET replace SPECT for evaluating CAD? The end of the beginning. J Nucl Cardiol 13:2–7PubMedCrossRef
10.
Lee SJ, Lee KH, Park SM et al (2007) Myocardial perfusion defects and coronary risk factors in symptomatic and asymptomatic elderly women. Int J Cardiovasc Imaging
11.
Koepfli P, Wyss CA, Namdar M et al (2004) Beta-adrenergic blockade and myocardial perfusion in coronary artery disease: differential effects in stenotic versus remote myocardial segments. J Nucl Med 45:1626–1631PubMed
12.
Margonato A, Chierchia SL, Xuereb RG et al (1995) Specificity and sensitivity of exercise-induced ST segment elevation for detection of residual viability: comparison with fluorodeoxyglucose and positron emission tomography. J Am Coll Cardiol 25:1032–1038PubMedCrossRef
13.
Austen WG, Edwards JE, Frye RL et al (1975) A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation 51:5–40PubMed
14.
Fagret D, Marie PY, Brunotte F et al (1995) Myocardial perfusion imaging with technetium-99 m-Tc NOET: comparison with thallium-201 and coronary angiography. J Nucl Med 36:936–943PubMed
15.
Berman DS, Kiat H, Friedman JD et al (1993) Separate acquisition rest thallium-201/stress technetium-99 m sestamibi dual-isotope myocardial perfusion single-photon emission computed tomography: a clinical validation study. J Am Coll Cardiol 22:1455–1464PubMedCrossRef
16.
Hor G, Sebening H, Sauer E et al (1979) 201Tl-redistribution analysis in early and delayed myocardial scintigrams of patients with coronary heart disease (CHD). Eur J Nucl Med 4:343–350PubMedCrossRef
17.
Garcia EV, Eisner RL, Patterson RE (1993) What should we expect from cardiac PET? J Nucl Med 34:978–980PubMed
18.
Heller GV, Bateman TM, Johnson LL et al (2004) Clinical value of attenuation correction in stress-only Tc-99 m sestamibi SPECT imaging. J Nucl Cardiol 11:273–281PubMedCrossRef
19.
Links JM, DePuey EG, Taillefer R, Becker LC (2002) Attenuation correction and gating synergistically improve the diagnostic accuracy of myocardial perfusion SPECT. J Nucl Cardiol 9:183–187PubMedCrossRef
20.
Masood Y, Liu YH, Depuey G et al (2005) Clinical validation of SPECT attenuation correction using X-ray computed tomography-derived attenuation maps: multicenter clinical trial with angiographic correlation. J Nucl Cardiol 12:676–686PubMedCrossRef
Metadata
Title
Diagnostic accuracy of myocardial perfusion imaging with single photon emission computed tomography and positron emission tomography: a comparison with coronary angiography
Authors
Lars Husmann
Mischa Wiegand
Ines Valenta
Oliver Gaemperli
Tiziano Schepis
Patrick T. Siegrist
Mehdi Namdar
Christophe A. Wyss
Hatem Alkadhi
Philipp A. Kaufmann
Publication date
01-06-2008
Publisher
Springer Netherlands
Published in
The International Journal of Cardiovascular Imaging / Issue 5/2008
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-007-9288-7

Other articles of this Issue 5/2008

The International Journal of Cardiovascular Imaging 5/2008 Go to the issue

Original Paper

Dipyridamole stress echocardiography stratifies outcomes of asymptomatic patients with recent myocardial revascularization

Original Paper

Initial evaluation of coronary images from 320-detector row computed tomography

Original Paper

Calcium scoring using 64-slice MDCT, dual source CT and EBT: a comparative phantom study

Original Paper

MRI of great vessel morphology and function in Ehlers-Danlos syndrome type IV

Original Paper

Strain and strain rate deformation parameters: from tissue Doppler to 2D speckle tracking

Case Report

Lower extremity peripheral vein bypass graft wall thickness changes demonstrated at 1 and 6 months after surgery with ultra-high spatial resolution black blood inner volume three-dimensional fast spin echo magnetic resonance imaging