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Published in: International Ophthalmology 1/2024

01-12-2024 | Diabetic Retinopathy | Original Paper

Resilient back-propagation machine learning-based classification on fundus images for retinal microaneurysm detection

Authors: S. Steffi, W. R. Sam Emmanuel

Published in: International Ophthalmology | Issue 1/2024

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Abstract

Background

The timely diagnosis of medical conditions, particularly diabetic retinopathy, relies on the identification of retinal microaneurysms. However, the commonly used retinography method poses a challenge due to the diminutive dimensions and limited differentiation of microaneurysms in images.

Problem Statement

Automated identification of microaneurysms becomes crucial, necessitating the use of comprehensive ad-hoc processing techniques. Although fluorescein angiography enhances detectability, its invasiveness limits its suitability for routine preventative screening.

Objective

This study proposes a novel approach for detecting retinal microaneurysms using a fundus scan, leveraging circular reference-based shape features (CR-SF) and radial gradient-based texture features (RG-TF).

Methodology

The proposed technique involves extracting CR-SF and RG-TF for each candidate microaneurysm, employing a robust back-propagation machine learning method for training. During testing, extracted features from test images are compared with training features to categorize microaneurysm presence.

Results

The experimental assessment utilized four datasets (MESSIDOR, Diaretdb1, e-ophtha-MA, and ROC), employing various measures. The proposed approach demonstrated high accuracy (98.01%), sensitivity (98.74%), specificity (97.12%), and area under the curve (91.72%).

Conclusion

The presented approach showcases a successful method for detecting retinal microaneurysms using a fundus scan, providing promising accuracy and sensitivity. This non-invasive technique holds potential for effective screening in diabetic retinopathy and other related medical conditions.
Literature
1.
2.
go back to reference Wilkinson C, Ferris FL, Klein RE et al (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110(9):1677–1682PubMedCrossRef Wilkinson C, Ferris FL, Klein RE et al (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110(9):1677–1682PubMedCrossRef
4.
go back to reference Ahmed NGA, Hamza MF, Hassan SN (2023) Knowledge, practice and attitude of diabetic patients regarding prevention of diabetic retinopathy. J Surv Fisher Sci 10(3S):3896–3908 Ahmed NGA, Hamza MF, Hassan SN (2023) Knowledge, practice and attitude of diabetic patients regarding prevention of diabetic retinopathy. J Surv Fisher Sci 10(3S):3896–3908
5.
go back to reference Lyssekboron A, Wylegala A, Polanowska K, Krysik K, Dobrowolski D (2017) Longitudinal changes in retinal nerve fiber layer thickness evaluated using avanti rtvue-xr optical coherence tomography after 23g vitrectomy for epiretinal membrane in patients with open-angle glaucoma. J Healthc Eng 2017:4673714–4673714PubMed Lyssekboron A, Wylegala A, Polanowska K, Krysik K, Dobrowolski D (2017) Longitudinal changes in retinal nerve fiber layer thickness evaluated using avanti rtvue-xr optical coherence tomography after 23g vitrectomy for epiretinal membrane in patients with open-angle glaucoma. J Healthc Eng 2017:4673714–4673714PubMed
7.
go back to reference Bernardes R, Serranho P, Lobo C (2011) Digital ocular fundus imaging: a review. Ophthalmological 226(4):161–181CrossRef Bernardes R, Serranho P, Lobo C (2011) Digital ocular fundus imaging: a review. Ophthalmological 226(4):161–181CrossRef
8.
go back to reference Chew EY, Ferris FL (2006) Chapter 67—nonproliferative diabetic retinopathy. In: Ryan SJ, Hinton DR, Schachat AP, Wilkinson CP (eds.) Retina, Fourth edition edn., Mosby, Edinburgh, pp 1271–1284 Chew EY, Ferris FL (2006) Chapter 67—nonproliferative diabetic retinopathy. In: Ryan SJ, Hinton DR, Schachat AP, Wilkinson CP (eds.) Retina, Fourth edition edn., Mosby, Edinburgh, pp 1271–1284
9.
go back to reference Eftekhari N, Pourreza HR, Masoudi M, Ghiasishirazi K, Saeedi E (2019) Microaneurysm detection in fundus images using a two-step convolutional neural network. Biomed Eng Online 18(1):67PubMedPubMedCentralCrossRef Eftekhari N, Pourreza HR, Masoudi M, Ghiasishirazi K, Saeedi E (2019) Microaneurysm detection in fundus images using a two-step convolutional neural network. Biomed Eng Online 18(1):67PubMedPubMedCentralCrossRef
10.
go back to reference Chaturvedi SS, Gupta K, Ninawe V, Prasad PS (2019) Advances in computer-aided Diagnosis of diabetic retinopathy. arXiv e-prints, 1909–09853 Chaturvedi SS, Gupta K, Ninawe V, Prasad PS (2019) Advances in computer-aided Diagnosis of diabetic retinopathy. arXiv e-prints, 1909–09853
11.
go back to reference Saha S, Xiao D, Bhuiyan A, Wong TY, Kanagasingam Y (2019) Color fundus image registration techniques and applications for automated analysis of diabetic retinopathy progression: a review. Biomed Signal Process Control 47:288–302CrossRef Saha S, Xiao D, Bhuiyan A, Wong TY, Kanagasingam Y (2019) Color fundus image registration techniques and applications for automated analysis of diabetic retinopathy progression: a review. Biomed Signal Process Control 47:288–302CrossRef
12.
go back to reference Salamat N, Missen MMS, Rashid A (2019) Diabetic retinopathy techniques in retinal images: a review. Artif Intell Med 97:168–188PubMedCrossRef Salamat N, Missen MMS, Rashid A (2019) Diabetic retinopathy techniques in retinal images: a review. Artif Intell Med 97:168–188PubMedCrossRef
13.
go back to reference Biyani RS, Patre BM (2018) Algorithms for red lesion detection in diabetic retinopathy: a review. Biomed Pharmacother 107:681–688PubMedCrossRef Biyani RS, Patre BM (2018) Algorithms for red lesion detection in diabetic retinopathy: a review. Biomed Pharmacother 107:681–688PubMedCrossRef
14.
go back to reference Chen Z, Chen B et al (2022) A preliminary observation on rod cell photo biomodulation in treating diabetic macular edema. Adv Ophthalmol Pract Res 2(2):10051 Chen Z, Chen B et al (2022) A preliminary observation on rod cell photo biomodulation in treating diabetic macular edema. Adv Ophthalmol Pract Res 2(2):10051
15.
go back to reference Lazar I, Hajdu A (2011) Microaneurysm detection in retinal images using a rotating cross-section-based model. In: 2011 IEEE international symposium on biomedical imaging: from nano to macro. Piscataway: IEEE, p 1405–1409 Lazar I, Hajdu A (2011) Microaneurysm detection in retinal images using a rotating cross-section-based model. In: 2011 IEEE international symposium on biomedical imaging: from nano to macro. Piscataway: IEEE, p 1405–1409
16.
go back to reference Lazar I, Hajdu A (2013) Retinal microaneurysm detection through local rotating cross-section profile analysis. IEEE TransMed Imaging 32(2):400–407CrossRef Lazar I, Hajdu A (2013) Retinal microaneurysm detection through local rotating cross-section profile analysis. IEEE TransMed Imaging 32(2):400–407CrossRef
17.
go back to reference Niemeijer M, Van Ginneken B, Staal J, Suttorp-Schulten MS, Abràmoff MD (2005) Automatic detection of red lesions in digital color fundus photographs. IEEE Trans Med Imaging 24(5):584–592PubMedCrossRef Niemeijer M, Van Ginneken B, Staal J, Suttorp-Schulten MS, Abràmoff MD (2005) Automatic detection of red lesions in digital color fundus photographs. IEEE Trans Med Imaging 24(5):584–592PubMedCrossRef
18.
go back to reference Giancardo L, Meriaudeau F, Karnowski TP, Li Y, Tobin KW, Chaum E (2011) Microaneurysm detection with radon transform-based classification on retina images. In: international conference of the IEEE engineering in medicine and biology society, pp 5939–5942 Giancardo L, Meriaudeau F, Karnowski TP, Li Y, Tobin KW, Chaum E (2011) Microaneurysm detection with radon transform-based classification on retina images. In: international conference of the IEEE engineering in medicine and biology society, pp 5939–5942
19.
go back to reference Zhang B, Wu X, You J, Li Q, Karray F (2010) Detection of microaneurysms using multi-scale correlation coefficients. Pattern Recogn 43(6):2237–2248ADSCrossRef Zhang B, Wu X, You J, Li Q, Karray F (2010) Detection of microaneurysms using multi-scale correlation coefficients. Pattern Recogn 43(6):2237–2248ADSCrossRef
20.
go back to reference Ram K, Joshi GD, Sivaswamy J (2011) A successive clutter-rejection-based approach for early detection of diabetic retinopathy. IEEE Trans Biomed Eng 58(3):664–673PubMedCrossRef Ram K, Joshi GD, Sivaswamy J (2011) A successive clutter-rejection-based approach for early detection of diabetic retinopathy. IEEE Trans Biomed Eng 58(3):664–673PubMedCrossRef
21.
go back to reference Saha, R., Chowdhury, A. R., & Banerjee, S. (2016). Diabetic retinopathy related lesions detection and classification using machine learning technology. In Artificial Intelligence and Soft Computing: 15th International Conference, ICAISC 2016, Zakopane, Poland, June 12–16, 2016, Proceedings, Part II 15 (pp. 734–745). Springer International Publishing. Saha, R., Chowdhury, A. R., & Banerjee, S. (2016). Diabetic retinopathy related lesions detection and classification using machine learning technology. In Artificial Intelligence and Soft Computing: 15th International Conference, ICAISC 2016, Zakopane, Poland, June 12–16, 2016, Proceedings, Part II 15 (pp. 734–745). Springer International Publishing.
22.
go back to reference Zhou W, Wu C, Chen D, Yi Y, Du W (2017) Automatic microaneurysm detection using the sparse principal component analysis-based unsupervised classification method. IEEE Access 5:2563–2572CrossRef Zhou W, Wu C, Chen D, Yi Y, Du W (2017) Automatic microaneurysm detection using the sparse principal component analysis-based unsupervised classification method. IEEE Access 5:2563–2572CrossRef
23.
go back to reference Srivastava R, Duan L, Wong DWK, Liu J, Wong TY (2016) Detecting retinal microaneurysms and haemorrhages with robustness to the presence of blood vessels. Comput Methods Progr Biomed 138:83–91CrossRef Srivastava R, Duan L, Wong DWK, Liu J, Wong TY (2016) Detecting retinal microaneurysms and haemorrhages with robustness to the presence of blood vessels. Comput Methods Progr Biomed 138:83–91CrossRef
24.
go back to reference Wu B, Zhu W, Shi F, Zhu S, Chen X (2017) Automatic detection of microaneurysms in retinal fundus images. Comput Med Imaging Gr 55:106–112CrossRef Wu B, Zhu W, Shi F, Zhu S, Chen X (2017) Automatic detection of microaneurysms in retinal fundus images. Comput Med Imaging Gr 55:106–112CrossRef
25.
go back to reference Wang S, Tang HL, Turk LA, Hu Y, Sanei S, Saleh GM, Peto T (2017) Localizing microaneurysms in fundus images through singular spectrum analysis. IEEE Trans Biomed Eng 64(5):990–1002ADSPubMedCrossRef Wang S, Tang HL, Turk LA, Hu Y, Sanei S, Saleh GM, Peto T (2017) Localizing microaneurysms in fundus images through singular spectrum analysis. IEEE Trans Biomed Eng 64(5):990–1002ADSPubMedCrossRef
26.
go back to reference Derwin DJ, Selvi ST, Singh OJ (2019) Secondary observer system for detection of microaneurysms in fundus images using texture descriptors. J Digit Imaging 33(1):159–167PubMedCentralCrossRef Derwin DJ, Selvi ST, Singh OJ (2019) Secondary observer system for detection of microaneurysms in fundus images using texture descriptors. J Digit Imaging 33(1):159–167PubMedCentralCrossRef
27.
go back to reference Mizutani A, Muramatsu C, Hatanaka Y, Suemori S, Hara T, Fujita H(2009) Automated microaneurysm detection method based on double-ring filter in retinal fundus images. In: proceedings of SPIE medical imaging, vol 7260, 2009, pp 72 601N–72 601N–8 Mizutani A, Muramatsu C, Hatanaka Y, Suemori S, Hara T, Fujita H(2009) Automated microaneurysm detection method based on double-ring filter in retinal fundus images. In: proceedings of SPIE medical imaging, vol 7260, 2009, pp 72 601N–72 601N–8
28.
go back to reference Zhang X (2014) Image processing methods for computer-aided screening of diabetic retinopathy, Ph.D. dissertation, EcoleNationaleSup´erieuredesMines de Paris, Paris Zhang X (2014) Image processing methods for computer-aided screening of diabetic retinopathy, Ph.D. dissertation, EcoleNationaleSup´erieuredesMines de Paris, Paris
29.
go back to reference Adal KM, Sidib D, Ali S, Chaum E, Karnowski TP, Mriaudeau F (2014) Automated detection of microaneurysms using scale-adapted blob analysis and semi-supervised learning. Comput Methods Programs Biomed 114(1):1–10PubMedCrossRef Adal KM, Sidib D, Ali S, Chaum E, Karnowski TP, Mriaudeau F (2014) Automated detection of microaneurysms using scale-adapted blob analysis and semi-supervised learning. Comput Methods Programs Biomed 114(1):1–10PubMedCrossRef
30.
go back to reference Dai B, Wu X, Bu W (2016) Retinal microaneurysms detection using gradient vector analysis and class imbalance classification. PLoS ONE 11(8):1–23CrossRef Dai B, Wu X, Bu W (2016) Retinal microaneurysms detection using gradient vector analysis and class imbalance classification. PLoS ONE 11(8):1–23CrossRef
31.
go back to reference Budak U, Şengür A, Guo Y, Akbulut Y (2017) A novel microaneurysms detection approach based on convolutional neural networks with reinforcement sample learning algorithm. Health Inf Sci Syst 5(1):14PubMedPubMedCentralCrossRef Budak U, Şengür A, Guo Y, Akbulut Y (2017) A novel microaneurysms detection approach based on convolutional neural networks with reinforcement sample learning algorithm. Health Inf Sci Syst 5(1):14PubMedPubMedCentralCrossRef
32.
go back to reference Wang S, Tang HL, Hu Y et al (2017) Localizing microaneurysms in fundus images through singular spectrum analysis. IEEE Trans Biomed Eng 64(5):990–1002ADSPubMedCrossRef Wang S, Tang HL, Hu Y et al (2017) Localizing microaneurysms in fundus images through singular spectrum analysis. IEEE Trans Biomed Eng 64(5):990–1002ADSPubMedCrossRef
33.
go back to reference Seoud L, Hurtut T, Chelbi J, Cheriet F, Langlois JMP (2016) Redlesion detection using dynamic shape features for diabetic retinopathy screening. IEEE Trans Med Imag 35(4):1116–1126CrossRef Seoud L, Hurtut T, Chelbi J, Cheriet F, Langlois JMP (2016) Redlesion detection using dynamic shape features for diabetic retinopathy screening. IEEE Trans Med Imag 35(4):1116–1126CrossRef
34.
go back to reference Eftekhari N et al (2019) Microaneurysm detection in fundus images using a two-step convolutional neural network. Biomed Eng Online 18(1):1–16CrossRef Eftekhari N et al (2019) Microaneurysm detection in fundus images using a two-step convolutional neural network. Biomed Eng Online 18(1):1–16CrossRef
35.
36.
go back to reference Habib MM et al (2017) Detection of microaneurysms in retinal images using an ensemble classifier. Inf Med Unlocked 9:44–57CrossRef Habib MM et al (2017) Detection of microaneurysms in retinal images using an ensemble classifier. Inf Med Unlocked 9:44–57CrossRef
37.
go back to reference Lazar I, Hajdu A (2013) Retinal microaneurysm detection through local rotating cross-section profile analysis. IEEE Trans Med Imag 32(2):400–407CrossRef Lazar I, Hajdu A (2013) Retinal microaneurysm detection through local rotating cross-section profile analysis. IEEE Trans Med Imag 32(2):400–407CrossRef
38.
go back to reference Zhang X (2014) Image processing methods for computer-aided screening of diabetic retinopathy, Ph.D. dissertation, EcoleNationaleSuperieure des ´ Mines de Paris, Paris Zhang X (2014) Image processing methods for computer-aided screening of diabetic retinopathy, Ph.D. dissertation, EcoleNationaleSuperieure des ´ Mines de Paris, Paris
39.
go back to reference Ali Shah SA, Laude A, Faye I, Tang TB (2016) Automated microaneurysm detection in diabetic retinopathy using curvelet transform. J Biomed Opt 21(10):101404PubMedCrossRef Ali Shah SA, Laude A, Faye I, Tang TB (2016) Automated microaneurysm detection in diabetic retinopathy using curvelet transform. J Biomed Opt 21(10):101404PubMedCrossRef
40.
go back to reference Wang S, Tang HL, Turk LIA et al (2017) Localizing microaneurysms in fundus images through singular spectrum analysis. IEEE Trans Biomed Eng 64(5):990–1002ADSPubMedCrossRef Wang S, Tang HL, Turk LIA et al (2017) Localizing microaneurysms in fundus images through singular spectrum analysis. IEEE Trans Biomed Eng 64(5):990–1002ADSPubMedCrossRef
41.
go back to reference Mayya V, Sowmya Kamath S, Kulkarni U (2021) Automated microaneurysms detection for early diagnosis of diabetic retinopathy: a comprehensive review. Comput Methods Progr Biomed Update 1:100013CrossRef Mayya V, Sowmya Kamath S, Kulkarni U (2021) Automated microaneurysms detection for early diagnosis of diabetic retinopathy: a comprehensive review. Comput Methods Progr Biomed Update 1:100013CrossRef
42.
go back to reference Suchetha M, Sai Ganesh N, Raman R, Edwin Dhas D (2021) Region of interest-based predictive algorithm for subretinal hemorrhage detection using faster R-CNN. Soft Comput 25(24):15255–15268PubMedPubMedCentralCrossRef Suchetha M, Sai Ganesh N, Raman R, Edwin Dhas D (2021) Region of interest-based predictive algorithm for subretinal hemorrhage detection using faster R-CNN. Soft Comput 25(24):15255–15268PubMedPubMedCentralCrossRef
43.
go back to reference Yadav D, Karn AK, Giddalur A, Dhiman A, Sharma S, Yadav AK (2021) Microaneurysm detection using color locus detection method. Measurement 176:109084CrossRef Yadav D, Karn AK, Giddalur A, Dhiman A, Sharma S, Yadav AK (2021) Microaneurysm detection using color locus detection method. Measurement 176:109084CrossRef
44.
go back to reference Dai B, Xiangqian Wu, Wei Bu (2016) Retinal microaneurysms detection using gradient vector analysis and class imbalance classification. PLoS ONE 11(8):e0161556PubMedPubMedCentralCrossRef Dai B, Xiangqian Wu, Wei Bu (2016) Retinal microaneurysms detection using gradient vector analysis and class imbalance classification. PLoS ONE 11(8):e0161556PubMedPubMedCentralCrossRef
45.
go back to reference Bradley D, Roth G (2007) Adapting thresholding using the integral image. J Gr Tools 12(2):13–21CrossRef Bradley D, Roth G (2007) Adapting thresholding using the integral image. J Gr Tools 12(2):13–21CrossRef
46.
go back to reference Naoum RS, Abid NA, Al-Sultani ZN (2012) An enhanced resilient backpropagation artificial neural network for the intrusion detection system. Int J Comput Sci Netw Secur (IJCSNS) 12(3):11 Naoum RS, Abid NA, Al-Sultani ZN (2012) An enhanced resilient backpropagation artificial neural network for the intrusion detection system. Int J Comput Sci Netw Secur (IJCSNS) 12(3):11
48.
go back to reference Kauppi T, Kalesnykiene V, Kamarainen J, Lensu L, Sorri I, Raninen A, Voutilainen R, Uusitalo H, K¨alvi¨ainen H, Pietil¨a J (2007) DIARETDB1diabeticretinopathy database and evaluation protocol. In: 11th conference on medical image understanding and analysis Kauppi T, Kalesnykiene V, Kamarainen J, Lensu L, Sorri I, Raninen A, Voutilainen R, Uusitalo H, K¨alvi¨ainen H, Pietil¨a J (2007) DIARETDB1diabeticretinopathy database and evaluation protocol. In: 11th conference on medical image understanding and analysis
49.
go back to reference Decenciere E, Cazuguel G, Zhang X et al (2013) TeleOphta: Machine learning and image processing methods for teleophthalmology. IRBM 34(2):196–203CrossRef Decenciere E, Cazuguel G, Zhang X et al (2013) TeleOphta: Machine learning and image processing methods for teleophthalmology. IRBM 34(2):196–203CrossRef
50.
go back to reference Niemeijer M, Van Ginneken B, Cree MJ et al (2010) Retinopathy online challenge: automatic detection of microaneurysms in digital color fundus photographs. IEEE Trans Med Imag 29(1):185–195CrossRef Niemeijer M, Van Ginneken B, Cree MJ et al (2010) Retinopathy online challenge: automatic detection of microaneurysms in digital color fundus photographs. IEEE Trans Med Imag 29(1):185–195CrossRef
Metadata
Title
Resilient back-propagation machine learning-based classification on fundus images for retinal microaneurysm detection
Authors
S. Steffi
W. R. Sam Emmanuel
Publication date
01-12-2024
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-024-02982-5

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