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American Journal of Clinical Dermatology

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Open Access 01-09-2020 | Diabetic Foot | Review Article

Skin Microbiota and its Interplay with Wound Healing

Authors: Marjana Tomic-Canic, Jamie L. Burgess, Katelyn E. O’Neill, Natasa Strbo, Irena Pastar

Published in: American Journal of Clinical Dermatology | Special Issue 1/2020

Abstract

The skin microbiota is intimately coupled with cutaneous health and disease. Interactions between commensal microbiota and the multiple cell types involved in cutaneous wound healing regulate the immune response and promote barrier restoration. This dialog between host cells and the microbiome is dysregulated in chronic wounds. In this review, we first describe how advances in sequencing approaches and analysis have been used to study the chronic wound microbiota, and how these findings underscored the complexity of microbial communities and their association with clinical outcomes in patients with chronic wound disorders. We also discuss the mechanistic insights gathered from multiple animal models of polymicrobial wound infections. In addition to the well-described role of bacteria residing in polymicrobial biofilms, we also discuss the role of the intracellular bacterial niche in wound healing. We describe how, in contrast to pathogenic species capable of subverting skin immunity, commensals are essential for the regulation of the cutaneous immune system and provide protection from intracellular pathogens through modulation of the antimicrobial molecule, Perforin-2. Despite recent advances, more research is needed to shed light on host-microbiome crosstalk in both healing and nonhealing chronic wounds to appropriately guide therapeutic developments.

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Title: Skin Microbiota and its Interplay with Wound Healing
Authors: Marjana Tomic-Canic
Jamie L. Burgess
Katelyn E. O’Neill
Natasa Strbo
Irena Pastar
Publication date: 01-09-2020
Publisher: Springer International Publishing
Keywords: Diabetic Foot
Respiratory Microbiota
Published in: American Journal of Clinical Dermatology / Issue Special Issue 1/2020
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI: https://doi.org/10.1007/s40257-020-00536-w

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Skin Microbiota and its Interplay with Wound Healing

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