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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2023

01-12-2023 | Diabetes | Original Article

Hip structural analysis, trabecular bone score, and bone mineral density in post-menopausal women with type-2 diabetes mellitus: a multi-center cross-sectional study in the south of Iran

Authors: Arzhang Naseri, Ehsan Shojaeefard, Marzieh Bakhshayeshkaram, Mohammad Mahdi Dabbaghmanesh, Seyed Taghi Heydari, Pedram Talezadeh, Mostafa Farhadi, Alireza Nikkhah, Mohammad Hossein Dabbaghmanesh

Published in: Archives of Osteoporosis | Issue 1/2023

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Abstract

Summary

This study aimed to evaluate bone mineral density (BMD), trabecular microarchitecture, and proximal hip geometry in diabetic postmenopausal women, where BMD alone cannot reflect bone strength adequately. We found significantly lower trabecular bone score and BMD at the distal radius and total forearm in diabetic subjects compared to controls.

Purpose

The limitations resulting from the exclusive assessment of bone mineral density (BMD) in people with diabetes can lead to underestimation of microarchitectural and geometric changes, both of which play an essential role in the fracture risk. Therefore, we aimed to evaluate BMD, trabecular bone score (TBS), and hip structural analysis (HSA) in diabetic type-2 post-menopausal women and compare them with healthy postmenopausal subjects.

Methods

BMD was assessed at the lumbar spine, femoral sites, distal radius, and total forearm using dual-energy X-ray absorptiometry (DXA); TBS was measured based on DXA images using the software at the same region of interest as the BMD measurements; geometric assessment at the proximal femur was performed by the HSA program.

Results

A total of 348 ambulatory type-2 diabetic postmenopausal women and 539 healthy postmenopausal women were enrolled. TBS and BMD at the distal radius and total forearm were significantly (P value < 0.05) lower in cases compared to controls after age and body mass index (BMI) adjustment. In addition, degraded bone microarchitecture was significantly (P value < 0.05) more prevalent in diabetic subjects than in non-diabetic controls after adjusting for age and BMI. A number of geometric indices of the proximal hip were significantly lower in the controls than in those with diabetes (P-value < 0.05).

Conclusion

This study may highlight the utility of the TBS and BMD at the distal radius and total forearm in subjects with type-2 diabetes mellitus, where the BMD at central sites may not adequately predict fracture risk.
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Metadata
Title
Hip structural analysis, trabecular bone score, and bone mineral density in post-menopausal women with type-2 diabetes mellitus: a multi-center cross-sectional study in the south of Iran
Authors
Arzhang Naseri
Ehsan Shojaeefard
Marzieh Bakhshayeshkaram
Mohammad Mahdi Dabbaghmanesh
Seyed Taghi Heydari
Pedram Talezadeh
Mostafa Farhadi
Alireza Nikkhah
Mohammad Hossein Dabbaghmanesh
Publication date
01-12-2023
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2023
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-023-01310-1

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