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Intensive Care Medicine

Published in:

01-03-2009 | Original

Diabetes mellitus is an independent risk factor for ICU-acquired bloodstream infections

Authors: M. Michalia, M. Kompoti, A. Koutsikou, A. Paridou, P. Giannopoulou, E. Trikka-Graphakos, P. Clouva-Molyvdas

Published in: Intensive Care Medicine | Issue 3/2009

Abstract

Objective

To investigate the role of diabetes as risk factor for ICU-acquired bloodstream infections (BSI).

Design

Prospective observational study.

Setting

A general eight-bed ICU of a tertiary hospital.

Patients

Three hundred and forty-three consecutive patients (63 diabetic and 280 nondiabetic) admitted in the ICU.

Methods

BSI episodes in the ICU were recorded and classified as primary, secondary, catheter-related and mixed according to strict criteria. In all patients, blood glucose was strictly controlled with a continuous insulin infusion within a range of 80–120 mg/dl.

Results

One-hundred and eighteen patients (34.4%) developed at least one BSI episode. Diabetic patients had an increased probability of developing at least one BSI episode compared with nondiabetic patients (hazard ratio = 1.66, 95% confidence interval 1.04–2.64, P = 0.034) in a Cox proportional hazards regression model adjusting for age, gender, admission category and APACHE II score at admission in the ICU and comorbidities.

Conclusions

Despite strict glycemic control, diabetic patients have a 1.7-fold probability of developing an ICU-acquired BSI compared to nondiabetic subjects.

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Title: Diabetes mellitus is an independent risk factor for ICU-acquired bloodstream infections
Authors: M. Michalia
M. Kompoti
A. Koutsikou
A. Paridou
P. Giannopoulou
E. Trikka-Graphakos
P. Clouva-Molyvdas
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 3/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1288-0

At a glance: The STEP trials

Springer Medicine

Diabetes mellitus is an independent risk factor for ICU-acquired bloodstream infections

Abstract

Objective

Design

Setting

Patients

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Design

Setting

Patients

Methods

Results

Conclusions

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