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Open Access 01-12-2018 | Letter

Dexmedetomidine: the first new kid on the block for preventing cardiac surgery-associated acute kidney injury?

Authors: Patrick M. Honore, David De Bels, Thierry Preseau, Herbert D. Spapen

Published in: Critical Care | Issue 1/2018

Excerpt

Cardiac surgery-associated acute kidney injury (CSA-AKI) affects up to 30% of patients undergoing cardiopulmonary bypass (CPB) surgery and is the second most common cause of AKI in the intensive care unit [1, 2]. To date, scarce evidence supports specific measures to prevent CSA-AKI. A recent meta-analysis by Shi and Tie [1] highlights the use of the selective α2-adrenoreceptor agonist dexmedetomidine (DEX) for prevention of CSA-AKI. The authors assume that this renoprotective effect is multifactorial, including both direct (by increasing renal blood flow (RBF) and diuresis) and indirect (by decreasing oxidative and inflammatory “stress”) effects on the kidney [1]. …

Shi R, Tie HT. Dexmedetomidine as a promising prevention strategy for cardiac surgery-associated acute kidney injury: a meta-analysis. Crit Care. 2017;21:198.CrossRefPubMedPubMedCentral

Gambardella I, Gaudino M, Ronco C, Lau C, Ivascu N, Girardi LN. Congestive kidney failure in cardiac surgery: the relationship between central venous pressure and acute kidney injury. Interact Cardiovasc Thorac Surg. 2016;23:800–5.CrossRefPubMed

Lannemyr L, Bragadottir G, Krumbholz V, Redfors B, Sellgren J, Ricksten SE. Effects of cardiopulmonary bypass on renal perfusion, filtration, and oxygenation in patients undergoing cardiac surgery. Anesthesiology. 2017;126:205–13.CrossRefPubMed

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Title: Dexmedetomidine: the first new kid on the block for preventing cardiac surgery-associated acute kidney injury?
Authors: Patrick M. Honore
David De Bels
Thierry Preseau
Herbert D. Spapen
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-018-2072-3

At a glance: The STEP trials

Springer Medicine

Dexmedetomidine: the first new kid on the block for preventing cardiac surgery-associated acute kidney injury?

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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