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01-07-2005 | Correspondence

Dexamethasone therapy and memory performance

Authors: Márcio Rodrigo Martins, Tatiana Barichello, Cristiane Ritter, Adalisa Reinke, João Quevedo, Felipe Dal-Pizzol

Published in: Intensive Care Medicine | Issue 7/2005

Excerpt

Sir: Brain injury with neurological sequelae induced by meningitis is well known in clinical practice. Inflammatory response and apoptotic pathways are related to meningitis-induced brain damage and cognitive impairment. However, the complete mechanism involved in this neurobehavioral impairment remains unclear. We read with interest the contribution by Dr. Irazuzta and colleagues [1] in which they evaluated neurobehavioral performance in the water maze in a rat model of bacterial meningitis with or without dexamethasone treatment. They demonstrated a significant water maze performance improvement in the animals treated with dexamethasone compared to placebo (bacteria and placebo) both 3 and 9 days after bacteria inoculation. In this context the work by Irazuzta et al. provide methodological advances because they present an old bacterial meningitis model in a new approach: the study of neurobehavioral impairment in bacterial meningitis survivors. This model provides the tools needed to investigate the mechanism involved in meningitis cognitive changes, as well as possible treatments. …

Irazuzta J, Pretzlaff RK, deCourten-Myers G, Zemlan F, Zingarelli B (2005) Dexamethasone decreases neurological sequelae and caspase activity. Intensive Care Med 31:146–150CrossRefPubMed

Roozendaal B (2000) Glucocorticoids and the regulation of memory consolidation. Psychoneuroendocrinology 25:213–238CrossRefPubMed

Quervain DJ de, Roozendaal B, McGaugh JL (1998) Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature 394:787–790

Barichello T, Martins MR, Reinke A, Feier G, Ritter C, Quevedo J, Dal-Pizzol F (2005) Cognitive impairment in sepsis survivors from cecal ligation and perforation. Crit Care Med 33:221–223CrossRefPubMed

Barichello T, Martins MR, Reinke A, Feier G, Ritter C, Quevedo J, Dal-Pizzol F (2005) Long-term cognitive impairment in sepsis survivors. Crit Care Med (in press)CrossRefPubMed

Title: Dexamethasone therapy and memory performance
Authors: Márcio Rodrigo Martins
Tatiana Barichello
Cristiane Ritter
Adalisa Reinke
João Quevedo
Felipe Dal-Pizzol
Publication date: 01-07-2005
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 7/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-005-2665-6

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Dexamethasone therapy and memory performance

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