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Breast Cancer Research
Published in: Breast Cancer Research 1/2010

01-05-2010 | Poster presentation

Developmental protein HOXC11 cooperates with SRC-1 in breast cancer: an adaptive response to endocrine therapy

Authors: M McIlroy, D McCartan, S Early, S Pennington, P O'Gaora, A Hill, L Young

Published in: Breast Cancer Research | Special Issue 1/2010

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Excerpt

The ability of a tumour to adapt and overcome targeted therapies has been recognised clinically for some time, but the molecular mechanisms driving this metamorphosis remain unclear. The steroid receptor coactivator protein, SRC-1, is a strong predictor of reduced disease-free survival in breast cancer patients. SRC-1 can also interact with nonsteroidal transcription factors, and defining these new transcriptional networks will uncover fresh strategies for managing endocrine resistance. …
Metadata
Title
Developmental protein HOXC11 cooperates with SRC-1 in breast cancer: an adaptive response to endocrine therapy
Authors
M McIlroy
D McCartan
S Early
S Pennington
P O'Gaora
A Hill
L Young
Publication date
01-05-2010
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 1/2010
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2518

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Keynote webinar | Spotlight on antibody–drug conjugates in cancer

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