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World Journal of Pediatrics
Published in: World Journal of Pediatrics 1/2022

01-01-2022 | Review Article

Developmental hemostasis in the neonatal period

Authors: Vicente Rey y Formoso, Ricardo Barreto Mota, Henrique Soares

Published in: World Journal of Pediatrics | Issue 1/2022

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Abstract

Background

The hemostatic system is complex and evolves continuously since gestation and well into the adult years, in a process known as “developmental hemostasis.”

Data sources

A comprehensive review was performed after an extensive literature search on PubMed/MEDLINE concerning developmental hemostasis during the neonatal period. Relevant cross references were also included.

Results

Although part of a system, each component of the hemostatic system evolves differently, with many displaying both quantitative and qualitative age-related differences. This leads to drastic disparities between the coagulation system of neonates and both other children’s and adults’, while still maintaining a generally balanced and physiological hemostasis. The motives behind this process remain to be fully elucidated but may be, at least in part, related to non-hemostatic factors.

Conclusions

Knowledge regarding “developmental hemostasis” is essential for everyone caring for newborns or even children in general and in this review, we describe each hemostatic system component’s neonatal characteristics and age-related progression as well as explore some of the possible physiological motives behind the process.
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Metadata
Title
Developmental hemostasis in the neonatal period
Authors
Vicente Rey y Formoso
Ricardo Barreto Mota
Henrique Soares
Publication date
01-01-2022
Publisher
Springer Singapore
Published in
World Journal of Pediatrics / Issue 1/2022
Print ISSN: 1708-8569
Electronic ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-021-00492-3

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