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AIDS and Behavior
Published in: AIDS and Behavior 1/2016

01-01-2016 | Original Paper

Developmental Cognitive Neuroscience of Adolescent Sexual Risk and Alcohol Use

Authors: Sarah W. Feldstein Ewing, Sephira G. Ryman, Arielle S. Gillman, Barbara J. Weiland, Rachel E. Thayer, Angela D. Bryan

Published in: AIDS and Behavior | Special Issue 1/2016

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Abstract

Human adolescents engage in very high rates of unprotected sex. This behavior has a high potential for unintended, serious, and sustained health consequences including HIV/AIDS. Despite these serious health consequences, we know little about the neural and cognitive factors that influence adolescents’ decision-making around sex, and their potential overlap with behaviorally co-occurring risk behaviors, including alcohol use. Thus, in this review, we evaluate the developmental neuroscience of sexual risk and alcohol use for human adolescents with an eye to relevant prevention and intervention implications.
Literature
1.
CDC. Youth risk behavior surveillance survey. MMWR Surveill Summ. 2013;66:1–172.
2.
Shedler J, Block J. Adolescent drug use and psychological health: a longitudinal inquiry. Am Psychol. 1990;45(5):612–30.PubMedCrossRef
3.
Feldstein Ewing SW, Bryan AD. A question of love and trust? The role of relationship factors in adolescent sexual decision-making. J Dev Behav Pediatr. 2015.
4.
CDC. Sexually transmitted infections among young Americans. In: National Center for HIV/AIDs VH, STD, and TB Prevention, editor. 2014.
5.
Cooper ML. Alcohol use and risky sexual behavior among college students and youth: evaluating the evidence. J Stud Alcohol Drugs. 2002;14:101–17.
6.
Cooper ML. Does drinking promote risky sexual behavior? A complex answer to a simple question. Curr Dir Psychol Sci. 2006;15:19–23.CrossRef
7.
Bryan AD, Ray LA, Cooper ML. Alcohol use and protective sexual behaviors among high-risk adolescents. J Stud Alcohol Drugs. 2007;68(3):327–35.PubMedCrossRef
8.
Mills KL, Goddings AL, Clasen LS, Giedd JN, Blakemore S-J. The developmental mismatch in structural brain maturation during adolescence. Dev Neurosci. 2014;36:147–60.PubMedCrossRef
9.
Goldenberg D, Telzer EH, Lieberman MD, Fuligni A, Galvan A. Neural mechanisms of impulse control in sexually risky adolescents. Dev Cogn Neurosci. 2013;6:23–9.PubMedPubMedCentralCrossRef
10.
Thayer RE, Montanaro E, Weiland BJ, Callahan TJ, Bryan AD. Exploring the relationship of functional network connectivity to latent trajectories of alcohol use and risky sex. Curr HIV Res. 2014;12:293–300.PubMedCrossRef
11.
Magnan RE, Callahan TJ, Ladd BO, Claus ED, Hutchison KE, Bryan AD. Evaluating an integrative theoretical framework for HIV sexual risk among juvenile justice involved adolescents. J AIDS Clin Res. 2013;4:217.PubMedPubMedCentralCrossRef
12.
Feldstein Ewing SW, Houck JM, Bryan AD. Neural activation during response inhibition is associated with adolescents’ frequency of risky sex and substance use. Addict Behav. 2015;44:80–7.PubMedCrossRef
13.
Hensel DJ, Hummer TA, Acrurio LR, James TW, Fortenberry JD. Feasibility of functional neuroimaging to understand adolescent women’s sexual decision making. J Adolesc Health. 2015;56:389–95.PubMedCrossRef
14.
Hall GS. Adolescence: Its psychology and relations to physiology, anthropology, sociology, sex, crime, religion, and education (Vols I & II). New York: D. Appleton & Co.; 1904.
15.
16.
17.
Somerville LH, Jones R, Casey BJ. A time of change: behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues. Brain Cogn. 2010;72:124–33.PubMedPubMedCentralCrossRef
18.
19.
20.
21.
Bechara A, Tranel D, Damasio H. Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain. 2000;123:2189–202.PubMedCrossRef
22.
Steinberg L. The influence of neuroscience on US Supreme Court decisions about adolescents’ criminal culpability. Nat Rev Neurosci. 2013;14:513–8.PubMedCrossRef
23.
Noel X. Why adolescents are at risk of misusing alcohol and gambling. Alcohol Alcohol. 2014;49:165–72.PubMedCrossRef
24.
Willoughby T, Good M, Adachi PJ, Hamza C, Tavernier R. Examining the link between adolescent brain development and risk taking from a social-developmental perspective. Brain Cogn. 2014;89:70–8.PubMedCrossRef
25.
Kawamichi H, Sasaki AT, Matsunaga M, Yoshihara K, Takahashi HK, Tanabe HC, et al. Medial prefrontal cortex activation is commonly invoked by reputation of self and romantic partners. PLoS One. 2013;8:e74958.PubMedPubMedCentralCrossRef
26.
Kuhn S, Gallinat J. Brain structure and functional connectivity associated with pornography consumption: the brain on porn. JAMA Psychiatry. 2014;71:827–34.PubMedCrossRef
27.
Donahue CH, Lee D. Dynamic routing of task-relevant signals for decision making in dorsolateral prefrontal cortex. Nat Neurosci. 2015;18:295–301.PubMedCrossRef
28.
Volkow ND, Baler RD. Addiction science: uncovering neurobiological complexity. Neuropharmacology. 2014;76:235–49.PubMedCrossRef
29.
30.
Luciana M, Segalowitz SJ. Some challenges for the triadic model for the study of adolescent development. Brain Cogn. 2014;39:118–21.CrossRef
31.
Spielberg JM, Olino TM, Forbes EE, Dahl RE. Exciting fear in adolescence: does pubertal development alter threat processing? Dev Cogn Neurosci. 2014;8:86–95.PubMedPubMedCentralCrossRef
32.
Ellis BJ. Determinants of pubertal timing: an evolutionary developmental approach. In: Ellis BJ, Bjorkland DF, editors. Origins of the social mind: evolutionary psychology and child development. New York: Guilford Press; 2005. p. 164–88.
33.
Stanton BF, Li X, Ricardo I, Galbraith J, Feigelman S, Kaljee L. A randomized, controlled effectiveness trial of an AIDS prevention program for low-income African-American youth. Arch Pediatr Adolesc Med. 1996;150:363–72.PubMedCrossRef
34.
Jemmott LS, Jemmott JB. Increasing condom use intentions among sexually active black adolescent women. Nurs Res. 1992;41:273–6.PubMed
35.
Schmiege SJ, Broaddus MR, Levin ME, Bryan AD. Randomized trial of group interventions to reduce HIV/STD risk and change theoretical mediators among detained adolescents. J Consult Clin Psychol. 2009;77(1):38–50.PubMedCrossRef
36.
Broaddus MR, Schmiege SJ, Bryan AD. An expanded model of the temporal stability of condom use intentions: gender-specific predictors among high-risk adolescents. Ann Behav Med. 2011;42:99–110.PubMedPubMedCentralCrossRef
37.
Rupp HA, James TW, Ketterson ED, Sengelaub DR, Jannsen E, Heiman JR. The role of the anterior cingulate cortex in women’s sexual decision making. Horm Behav. 2009;1:42–7.
38.
Pfaus JG, Kippin TE, Coria-Avila GA. What can animal models tell us about human sexual response? Annu Rev Sex Res. 2003;14:1–63.PubMed
39.
Pfaus JG, Kippin TE, Coria-Avila GA, Gelez HA, Afonso VM, Ismail N, Parada M. Who, what, where, when (and maybe even why?) How the experience of sexual reward connects sexual desire, preference, and performance. Arch Sex Behav. 2012;41:31–62.PubMedCrossRef
40.
Casey BJ. Beyond simple models of self-control to circuit-based accounts of adolescent behavior. Annu Rev Psychol. 2015;66(1–6):25.
41.
Dir AL, Coskunipar A, Cyders MA. A meta-analytic review of the relationship between adolescent risky sexual behavior and impulsivity across gender, age, and race. Clin Psychol Rev. 2014;34:551–62.PubMedCrossRef
42.
Pharo H, Clark S, Graham M, Gross J, Hayne H. Risky business: executive function, personality, and reckless behavior during adolescence and emerging adulthood. Behav Neurosci. 2011;125:970–8.PubMedCrossRef
43.
Heitzig MM, Villafuerte S, Weiland BJ, Enoch MA, Burmeister M, Zubieta JK, et al. Effect of GABRA2 genotype on development of incentive-motivation circuitry in a sample enriched for alcoholism risk. Neuropsychopharmacology. 2014;39:3077–86.CrossRef
44.
Ernst M, Nelson EE, Jazbec S, McClure EB, Monk CS, Leibenluft E, et al. Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents. Neuroimage. 2005;25(4):1279–91.PubMedCrossRef
45.
Galvan A, Hare TA, Parra CE, Penn J, Voss K, Glover G, et al. Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents. J Neurosci. 2006;26(25):6885–92.PubMedCrossRef
46.
Seeman P, Bzowej NH, Guan HC, Bergeron C, Becker LE, Reynolds GP. Human brain dopamine receptors in children and aging adults. Synapse. 1987;1:399–404.PubMedCrossRef
47.
Van Leijenhorst L, Zanolie K, Van Meel CS, Westenberg PM, Rombouts SA, Crone EA. What motivates the adolescent? Brain regions mediating reward sensitivity across adolescence. Cereb Cortex. 2010;20:61–9.PubMedCrossRef
48.
Raznahan A, Shaw PW, Lerch JP, Clasen LS, Greenstein D, Berman R, et al. Longitudinal four-dimensional mapping of subcortical anatomy in human development. Proc Natl Acad Sci USA. 2014;111:1592–7.PubMedPubMedCentralCrossRef
49.
Voon V, Mole TB, Banca P, Porter L, Morris L, Mitchell S, et al. Neural correlates of sexual cue reactivity in individuals with and without compulsive sexual behavior. PLoS One. 2014;9:e102419.PubMedPubMedCentralCrossRef
50.
Rupp HA, James TW, Ketterson ED, Sengelaub DR, Ditzen B, Heiman JR. Lower sexual interest in postpartum women: relationship to amygdala activation and intranasal oxytocin. Horm Behav. 2013;63:114–21.PubMedPubMedCentralCrossRef
51.
Alarcon G, Cservenka A, Rudolph MD, Fair DA, Nagel BJ. Developmental sex differences in resting state functional connectivity of amygdala sub-regions. Neuroimage. 2015;115:235–44.PubMedCrossRef
52.
Scherf KS, Smyth JM, Delgado MR. The amygdala: an agent of change in adolescent neural networks. Horm Behav. 2013;64:64.CrossRef
53.
54.
Lefkowtiz ES, Shearer CL, Gillen MM, Espinosa-Hernandez G. How gendered attitudes relate to women’s and men’s sexual behaviors and beliefs. Sex Cult. 2014;18:833–46.CrossRef
55.
Feldstein Ewing SW, Ryman SG, Karoly H, Mayer AR, Ling J, Bryan AD. Protected sexual intercourse and the adolescent brain: gender matters (under review).
56.
57.
Feldstein Ewing SW, Blakemore S-J, Sakhardande A. The effect of alcohol consumption on the adolescent brain: a systematic review of MRI and fMRI studies of alcohol-using youth. Neuroimage. 2014;5:420–37.CrossRef
58.
Ryman SG, Bryan AD, Thayer RE, Mayer AR, Ling J, Feldstein Ewing SW. The association between protected sex and the adolescent brain (under review).
59.
Lisdahl KM, Gilbart ER, Wright NE, Shollenbarger S. Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function. Front Psychiatry. 2013;4:53.PubMedPubMedCentralCrossRef
60.
Bryan AD, Schmiege SJ, Magnan RE. Marijuana use and risky sexual behavior among high-risk adolescents: trajectories, risk factors, and event-level relationships. Dev Psychol. 2012;48:1429–42.PubMedCrossRef
61.
Feldstein Ewing SW, Houck JM, Bryan AD. Examining the brain-behavioral interplay between adolescent substance use, sexual risk, and response inhibition (under review).
62.
Robin L, Dittus P, Whitaker D, Crosby R, Ethier K, Mezoff J, et al. Behavioral interventions to reduce incidence of HIV, STD, and pregnancy among adolescents: a decade in review. J Adolesc Health. 2004;34:3–26.PubMedCrossRef
63.
Kirby DB, Laris BA, Rolleri LA. Sex and HIV education programs: their impact on sexual behaviors of young people throughout the world. J Adolesc Health. 2007;40:206–17.PubMedCrossRef
64.
Conner M, McEachan R, Taylor N, O’Hara J, Lawton R. Role of affective attitudes and anticipated affective reactions in predicting health behaviors. Health Psychol. 2015;34:642–52.PubMedCrossRef
65.
Sheeran P, Gollwitzer PM, Bargh JA. Nonconscious processes and health. Health Psychol. 2013;32:460–73.PubMedCrossRef
66.
Sniehotta FF, Presseau J, Araujo-Soares V. Time to retire the theory of planed behavior. Health Psychol Rev. 2014;8:1–7.PubMedCrossRef
67.
Pachankis JE, Rendina HJ, Restar A, Ventuneac A, Grov C, Parsons JT. A minority stress-emotion regulation model of sexual compulsivity among highly sexually active gay and bisexual men. Health Psychol. 2014;34:829–40.PubMedCrossRef
68.
Simons JS, Maisto SA, Wray TB, Emery NN. Acute effects of intoxication and arousal on approach/avoidance biases toward sexual risk stimuli in heterosexual men. Arch Sex Behav. 2015.
69.
Wehrum-Osinsky S, Klucken T, Kagerer S, Walter B, Hermann A, Stark R. At the second glance: stability of neural responses toward visual sexual stimuli. J Sex Med. 2014;11:2720–37.PubMedCrossRef
Metadata
Title
Developmental Cognitive Neuroscience of Adolescent Sexual Risk and Alcohol Use
Authors
Sarah W. Feldstein Ewing
Sephira G. Ryman
Arielle S. Gillman
Barbara J. Weiland
Rachel E. Thayer
Angela D. Bryan
Publication date
01-01-2016
Publisher
Springer US
Published in
AIDS and Behavior / Issue Special Issue 1/2016
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-015-1155-2

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