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01-08-2008 | Case Report

Development of Vitreous Haemorrhage during Treatment with Bevacizumab for Metastatic Rectal Cancer

Authors: Gwo-Che Huang, Lee-Jen Chen, Hung-Chang Liu, Dr Yu-Jen Chen

Published in: Clinical Drug Investigation | Issue 8/2008

Abstract

Bevacizumab is a recombinant humanized monoclonal antibody with activity against vascular endothelial growth factor used in the treatment of various cancers. This case report describes a 68-year-old male with rectal cancer who developed a vitreous haemorrhage during treatment with bevacizumab. After vitrectomy the vitreous haemorrhage subsided and visual acuity was restored. The patient had evidence of age-related macular degeneration (AMD), which may have induced the development of vitreous haemorrhage. This implies that AMD might serve as a risk factor for vitreous haemorrhage in cancer patients treated with systemic bevacizumab. Ophthalmological examination to identify AMD lesions may be necessary prior to administration of bevacizumab. Vitrectomy could serve as a management tool for bevacizumab-associated vitreous haemorrhage.

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Title: Development of Vitreous Haemorrhage during Treatment with Bevacizumab for Metastatic Rectal Cancer
Authors: Gwo-Che Huang
Lee-Jen Chen
Hung-Chang Liu
Dr Yu-Jen Chen
Publication date: 01-08-2008
Publisher: Springer International Publishing
Published in: Clinical Drug Investigation / Issue 8/2008
Print ISSN: 1173-2563
Electronic ISSN: 1179-1918
DOI: https://doi.org/10.2165/00044011-200828080-00007

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Development of Vitreous Haemorrhage during Treatment with Bevacizumab for Metastatic Rectal Cancer

Abstract

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Springer Medicine

Abstract

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