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01-12-2008

Development of Cerebellar GABAergic Interneurons: Origin and Shaping of the “Minibrain” Local Connections

Authors: Ketty Leto, Alice Bartolini, Ferdinando Rossi

Published in: The Cerebellum | Issue 4/2008

Abstract

The cerebellar circuits comprise a limited number of neuronal phenotypes embedded in a defined cytoarchitecture and generated according to specific spatio-temporal patterns. The local GABAergic network is composed of several interneuron phenotypes that play essential roles in information processing by modulating the activity of cerebellar cortical inputs and outputs. A major issue in the study of cerebellar development is to understand the mechanisms that underlie the generation of different interneuron classes and regulate their placement in the cerebellar architecture and integration in the cortico-nuclear network. Recent findings indicate that the variety of cerebellar interneurons derives from a single population of multipotent progenitors whose fate choices are determined by instructive environmental information. Such a strategy, which is unique for the cerebellum along the neuraxis, allows great flexibility in the control of the quality and quantity of GABAergic interneurons that are produced, thus facilitating the adaptive shaping of the cerebellar network to specific functional demands.

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Title: Development of Cerebellar GABAergic Interneurons: Origin and Shaping of the “Minibrain” Local Connections
Authors: Ketty Leto
Alice Bartolini
Ferdinando Rossi
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: The Cerebellum / Issue 4/2008
Print ISSN: 1473-4222
Electronic ISSN: 1473-4230
DOI: https://doi.org/10.1007/s12311-008-0079-z

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Development of Cerebellar GABAergic Interneurons: Origin and Shaping of the “Minibrain” Local Connections

Abstract

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Abstract

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