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Journal of Cardiovascular Translational Research

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01-06-2018 | Original Article

Development of an Off-the-Shelf Tissue-Engineered Sinus Valve for Transcatheter Pulmonary Valve Replacement: a Proof-of-Concept Study

Authors: Sarah E. Motta, Emanuela S. Fioretta, Petra E. Dijkman, Valentina Lintas, Luc Behr, Simon P. Hoerstrup, Maximilian Y. Emmert

Published in: Journal of Cardiovascular Translational Research | Issue 3/2018

Abstract

Tissue-engineered heart valves with self-repair and regeneration properties may overcome the problem of long-term degeneration of currently used artificial prostheses. The aim of this study was the development and in vivo proof-of-concept of next-generation off-the-shelf tissue-engineered sinus valve (TESV) for transcatheter pulmonary valve replacement (TPVR). Transcatheter implantation of off-the-shelf TESVs was performed in a translational sheep model for up to 16 weeks. Transapical delivery of TESVs was successful and showed good acute and short-term performance (up to 8 weeks), which then worsened over time most likely due to a non-optimized in vitro valve design. Post-mortem analyses confirmed the remodelling potential of the TESVs, with host cell infiltration, polymer degradation, and collagen and elastin deposition. TESVs proved to be suitable as TPVR in a preclinical model, with encouraging short-term performance and remodelling potential. Future studies will enhance the clinical translation of such approach by improving the valve design to ensure long-term functionality.

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Title: Development of an Off-the-Shelf Tissue-Engineered Sinus Valve for Transcatheter Pulmonary Valve Replacement: a Proof-of-Concept Study
Authors: Sarah E. Motta
Emanuela S. Fioretta
Petra E. Dijkman
Valentina Lintas
Luc Behr
Simon P. Hoerstrup
Maximilian Y. Emmert
Publication date: 01-06-2018
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 3/2018
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-018-9800-6

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Development of an Off-the-Shelf Tissue-Engineered Sinus Valve for Transcatheter Pulmonary Valve Replacement: a Proof-of-Concept Study

Abstract

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Abstract

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