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Surgery Today
Published in: Surgery Today 5/2018

01-05-2018 | Original Article

Development of a new surgical sheet containing both silk fibroin and thermoplastic polyurethane for cardiovascular surgery

Authors: Ryo Shimada, Hayato Konishi, Hideki Ozawa, Takahiro Katsumata, Ryou Tanaka, Yasumoto Nakazawa, Shintaro Nemoto

Published in: Surgery Today | Issue 5/2018

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Abstract

Purpose

The surgical sheets that are currently used for congenital cardiovascular surgery have several drawbacks, including material deterioration, calcification, and pseudo-intimal proliferation resulting in hemodynamic disturbance. The aim of this study was to evaluate a newly developed sheet made from a combination of silk fibroin (SF) and a synthetic polymer, thermoplastic polyurethane (TPU), for surgical use.

Methods

The hybrid SF/TPU sheet was a non-woven fabric with nanofibers that was made using the electrospinning method. The mechanical properties of the SF/TPU sheet were characterized. To determine its biocompatibility, part of the wall of the canine descending aorta was replaced with a SF/TPU sheet as a patch. The patches were removed after 3 months and a histological examination was performed.

Results

The flexibility, water permeability, and suture retention strength of the SF/TPU sheet were excellent and equivalent to those of existing sheets. The SF/TPU sheet had excellent handling properties and fit well into the vascular wall without needle hole bleeding. The histological examination revealed that the intimal tissue was restored well over the intraluminal surface of the explanted SF/TPU sheet, the absence of calcium deposition, and minimal inflammatory reaction, without signs of degradation.

Conclusion

The SF/TPU sheet had excellent mechanical properties and tissue biocompatibility. These favorable features and possible biodegradability of the SF portion warrant a long-term follow-up study.
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Metadata
Title
Development of a new surgical sheet containing both silk fibroin and thermoplastic polyurethane for cardiovascular surgery
Authors
Ryo Shimada
Hayato Konishi
Hideki Ozawa
Takahiro Katsumata
Ryou Tanaka
Yasumoto Nakazawa
Shintaro Nemoto
Publication date
01-05-2018
Publisher
Springer Singapore
Published in
Surgery Today / Issue 5/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-017-1615-6

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