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International Archives of Occupational and Environmental Health

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01-08-2009 | Original Article

Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children

Authors: Kyoung-Ho Lee, Roel Vermeulen, Virissa Lenters, Soo-Hun Cho, Paul T. Strickland, Daehee Kang

Published in: International Archives of Occupational and Environmental Health | Issue 8/2009

Abstract

Objectives

This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children.

Methods

Urine samples were collected from 102 non-smoking children (aged 10–14). Urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy, following immuno-affinity purification using monoclonal antibody 8E11. Urinary cotinine, a metabolite of nicotine, was measured by GC/MS. Information on environmental tobacco smoke (ETS) exposure, diet, fuel type for heating home, and other possible sources of PAH exposure was collected by self-administered questionnaires.

Results

Mean (±SE) 1-OHPG levels were 1.64 (±0.06) ng/ml (range 0.04–3.27 ng/ml). Two multiple linear regression analyses (differing in how ETS was approximated: by parental smoking or urinary cotinine) revealed a positive association between urinary 1-OHPG levels and parental smoking at home (P = 0.007), log urinary cotinine (P = 0.165), frequent grilled (shell)fish consumption (P = 0.061), and living in a commercial/other zone (P = 0.007) versus a residential or industrial zone. No consistent associations were found between 1-OHPG and the child’s sex, grilled meat consumption, or fuels used to heat the home.

Conclusions

These results support that ETS, frequent grilled fish consumption, and the ambient environment are important predictors of urinary 1-OHPG levels in South Korean children.

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Title: Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children
Authors: Kyoung-Ho Lee
Roel Vermeulen
Virissa Lenters
Soo-Hun Cho
Paul T. Strickland
Daehee Kang
Publication date: 01-08-2009
Publisher: Springer-Verlag
Published in: International Archives of Occupational and Environmental Health / Issue 8/2009
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-008-0385-2

At a glance: The STEP trials

Springer Medicine

Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children

Abstract

Objectives

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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