Top

Published in:

01-11-2014 | 2014 SSAT Poster Presentation

Determinants of Repeat Curative Intent Surgery in Colorectal Liver Metastasis

Authors: Afif N. Kulaylat, Neil H. Bhayani, Audrey L. Stokes, Jane R. Schubart, Joyce Wong, Eric T. Kimchi, Kevin F. Staveley-O’Carroll, Jussuf T. Kaifi, Niraj J. Gusani

Published in: Journal of Gastrointestinal Surgery | Issue 11/2014

Abstract

Introduction

Following curative intent surgery (CIS) for colorectal liver metastasis (CRLM), repeat CIS for recurrence improves survival. The factors associated with repeat CIS are not widely reported.

Methods

An institutional database (January 2002–December 2012) was reviewed to evaluate factors influencing repeat CIS.

Results

One hundred sixty-three patients with colorectal liver metastasis (CRLM) underwent successful CIS. Median follow-up and disease-free interval (DFI) was 33 and 16 months, respectively. After initial CIS, 102 patients (63 %) recurred. Fifty-three patients (52 %) underwent a repeat CIS. After repeat CIS, 33 patients (62 %) developed a second recurrence, and in 13 patients (39 %), a third CIS was possible. DFI decreased following initial CIS (first CIS vs. second CIS vs. third CIS [20 vs. 15 vs. 8.5 months], p < 0.001). Overall 5-year survival in all patients was 55 %; patients who recurred had a 5-year survival of 67 % if they underwent repeat CIS vs. 7.8 % if they were managed palliatively. Second CIS was less likely with a postoperative complication, other/multifocal recurrence, or DFI <12 months.

Conclusion

Despite high recurrence and decreasing DFI, repeat CIS provides a survival benefit. Postoperative complications, DFI, number, and pattern of recurrence influence the decision to pursue repeat CIS.

de Jong MC, Mayo SC, Pulitano C, Lanella S, Ribero D, Strub J, Hubert C, Gigot JF, Schulick RD, Choti MA, Aldrighetti L, Mentha G, Capussotti L, Pawlik TM. Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis: results from an international multi-institutional analysis. J Gastrointest Surg 2009;13:2141-2151.CrossRefPubMed

Chua TC, Saxena A, Chu F, Zhao J, Morris DL. Predictors of cure after hepatic resection of colorectal liver metastases: an analysis of actual 5- and 10-year survivors. J Surg Oncol 2011;103:796-800.CrossRefPubMed

Mayo SC, Pawlik TM. Current management of colorectal hepatic metastasis. Expert Rev Gastroenterol Hepatol 2009;3:131-144.CrossRefPubMed

Nikfarjam M, Shereef S, Kimchi ET, Gusani NJ, Jiang Y, Avella DM, Mahraj RP, Staveley-O’Carroll KF. Survival outcomes of patients with colorectal liver metastases following hepatic resection or ablation in the era of effective chemotherapy. Ann Surg Oncol 2009;16:1860-1867.CrossRefPubMed

Cao CQ, Yan TD, Liauw W, Morris DL. Comparison of optimally resected hepatectomy and peritonectomy patients with colorectal cancer metastasis. J Surg Oncol 2009;100:529-533.CrossRefPubMed

Sa Cunha A, Laurent C, Rault A, Couderc P, Rullier E, Saric J. A second liver resection due to recurrent colorectal liver metastases. Arch Surg 2007;142:1144-1149; discussion 1150.CrossRefPubMed

Mise Y, Imamura H, Hashimoto T, Seyama Y, Aoki T, Hasegawa K, Beck Y, Sugawara Y, Makuuchi M, Nakajima J, Kokudo N. Cohort study of the survival benefit of resection for recurrent hepatic and/or pulmonary metastases after primary hepatectomy for colorectal metastases. Ann Surg 2010;251:902-909.CrossRefPubMed

Kaifi JT, Gusani NJ, Deshaies I, Kimchi ET, Reed MF, Mahraj RP, Staveley-O'Carroll KF. Indications and approach to surgical resection of lung metastases. J Surg Oncol 2010;102:187-195.CrossRefPubMed

Adam R, Pascal G, Azoulay D, Tanaka K, Castaing D, Bismuth H. Liver resection for colorectal metastases: the third hepatectomy. Ann Surg 2003;238:871-883; discussion 883-884.PubMedCentralCrossRefPubMed

10.

Nordlinger B, Vaillant JC, Guiguet M, Balladur P, Paris F, Bachellier P, Jaeck D. Survival benefit of repeat liver resections for recurrent colorectal metastases: 143 cases. Association Francaise de Chirurgie. J Clin Oncol 1994;12:1491-1496.PubMed

11.

Adam R, Bismuth H, Castaing D, Waechter F, Navarro F, Abascal A, Majno P, Engerran L. Repeat hepatectomy for colorectal liver metastases. Ann Surg 1997;225:51-60; discussion 60-62.PubMedCentralCrossRefPubMed

12.

Shaw IM, Rees M, Welsh FK, Bygrave S, John TG. Repeat hepatic resection for recurrent colorectal liver metastases is associated with favourable long-term survival. Br J Surg 2006;93:457-464.CrossRefPubMed

13.

Petrowsky H, Gonen M, Jarnagin W, Lorenz M, DeMatteo R, Heinrich S, Encke A, Blumgart L, Fong Y. Second liver resections are safe and effective treatment for recurrent hepatic metastases from colorectal cancer: a bi-institutional analysis. Ann Surg 2002;235:863-871.PubMedCentralCrossRefPubMed

14.

Pessaux P, Lermite E, Brehant O, Tuech JJ, Lorimier G, Arnaud JP. Repeat hepatectomy for recurrent colorectal liver metastases. J Surg Oncol 2006;93:1-7.CrossRefPubMed

15.

Wicherts DA, de Haas RJ, Salloum C, Andreani P, Pascal G, Sotirov D, Adam R, Castaing D, Azoulay D. Repeat hepatectomy for recurrent colorectal metastases. Br J Surg 2013;100:808-818.CrossRefPubMed

16.

Mavros MN, de Jong M, Dogeas E, Hyder O, Pawlik TM. Impact of complications on long-term survival after resection of colorectal liver metastases. Br J Surg 2013;100:711-718.CrossRefPubMed

17.

Farid SG, Aldouri A, Morris-Stiff G, Khan AZ, Toogood GJ, Lodge JP, Prasad KR. Correlation between postoperative infective complications and long-term outcomes after hepatic resection for colorectal liver metastasis. Ann Surg 2010;251:91-100.CrossRefPubMed

18.

Karanicolas PJ, Jarnagin WR, Gonen M, Tuorto S, Allen PJ, DeMatteo RP, D’Angelica MI, Fong Y. Long-term outcomes following tumor ablation for treatment of bilateral colorectal liver metastases. JAMA Surg 2013;148:597-601.PubMedCentralCrossRefPubMed

19.

Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 1999;230:309-318; discussion 318-321.PubMedCentralCrossRefPubMed

20.

Zacharia TT, Saini S, Halpern EF, Sumner JE. CT of colon cancer metastases to the liver using modified RECIST criteria: determining the ideal number of target lesions to measure. AJR Am J Roentgenol 2006;186:1067-1070.CrossRefPubMed

21.

Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004;240:205-213.PubMedCentralCrossRefPubMed

22.

Pawlik TM, Schulick RD, Choti MA. Expanding criteria for resectability of colorectal liver metastases. Oncologist 2008;13:51-64.CrossRefPubMed

23.

Chen F, Sakai H, Miyahara R, Bando T, Okubo K, Date H. Repeat resection of pulmonary metastasis is beneficial for patients with colorectal carcinoma. World J Surg 2010;34:2373-2378.CrossRefPubMed

24.

Sugawara G, Isogai M, Kaneoka Y, Suzuki M, Yamaguchi A. Repeat hepatectomy for recurrent colorectal metastases. Surg Today 2005;35:282-289.CrossRefPubMed

25.

Mansour JC. Repeated Resection of Colorectal Liver Metastases. Curr Colorectal Cancer Rep 2014.

26.

Hendren S, Birkmeyer JD, Yin H, Banerjee M, Sonnenday C, Morris AM. Surgical complications are associated with omission of chemotherapy for stage III colorectal cancer. Dis Colon Rectum 2010;53:1587-1593.CrossRefPubMed

27.

Matsuda A, Matsumoto S, Seya T, Matsutani T, Kishi T, Yokoi K, Wang P, Uchida E. Does postoperative complication have a negative impact on long-term outcomes following hepatic resection for colorectal liver metastasis?: a meta-analysis. Ann Surg Oncol 2013;20:2485-2492.CrossRefPubMed

28.

Merkow RP, Bentrem DJ, Mulcahy MF, Chung JW, Abbott DE, Kmiecik TE, Stewart AK, Winchester DP, Ko CY, Bilimoria KY. Effect of postoperative complications on adjuvant chemotherapy use for stage III colon cancer. Ann Surg 2013;258:847-853.CrossRefPubMed

Title: Determinants of Repeat Curative Intent Surgery in Colorectal Liver Metastasis
Authors: Afif N. Kulaylat
Neil H. Bhayani
Audrey L. Stokes
Jane R. Schubart
Joyce Wong
Eric T. Kimchi
Kevin F. Staveley-O’Carroll
Jussuf T. Kaifi
Niraj J. Gusani
Publication date: 01-11-2014
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 11/2014
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-014-2580-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Determinants of Repeat Curative Intent Surgery in Colorectal Liver Metastasis

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 11/2014

Defining Perioperative Risk after Hepatectomy Based on Diagnosis and Extent of Resection

IGF-2 Is Necessary for Retinoblastoma-Mediated Enhanced Adaptation after Small-Bowel Resection

RETRACTED ARTICLE: Does the Hepatic Branch of Vagus Mediate the Secretion of Glucagon-Like Peptide-1 During the Roux-en-Y Gastric Bypass Surgery?

Endoscopy in the Early Postoperative Setting after Primary Gastrointestinal Anastomosis

Anatomic Versus Nonanatomic Hepatectomy for a Solitary Hepatocellular Carcinoma

GERD Procedures: When and What?