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01-09-2013 | Short Communication

Detection of human herpesvirus 8 sequences in cutaneous cherry angiomas

Authors: Alessandro Borghi, Sabrina Benedetti, Monica Corazza, Valentina Gentili, Giulia Ruina, Dario Di Luca, Anna Virgili, Elisabetta Caselli

Published in: Archives of Dermatological Research | Issue 7/2013

Abstract

Cherry angiomas (CAs) are common vascular benign skin tumors, characterized by abnormal angiogenesis, whose etiology is still unclear and poorly studied. We investigated the presence of HHV8 in CAs due to virus ability of inducing neoangiogenesis in endothelial cells. A total of 29 patients were enrolled in a randomized, controlled, blinded analysis of skin specimens including various vascular lesions. All clinical samples were anonymized and analyzed by three different biomolecular assays to minimize the risk of false positive/negative results. Results showed that 53 % of eruptive CAs harbor HHV8 sequences, with the highest viral loads in samples derived from immunosuppressed patients. By contrast, no paucilesional CAs were positive for HHV8. Considering HHV8 prevalence in the Mediterranean population (10–15 %), results obtained in eruptive CAs are significant and suggest for the first time a possible involvement of HHV8 in eruptive cherry angiomas development, particularly in the context of immunosuppression, similar to that recognized for major HHV8-induced pathologies.

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Title: Detection of human herpesvirus 8 sequences in cutaneous cherry angiomas
Authors: Alessandro Borghi
Sabrina Benedetti
Monica Corazza
Valentina Gentili
Giulia Ruina
Dario Di Luca
Anna Virgili
Elisabetta Caselli
Publication date: 01-09-2013
Publisher: Springer Berlin Heidelberg
Published in: Archives of Dermatological Research / Issue 7/2013
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-013-1346-5

At a glance: The STEP trials

Springer Medicine

Detection of human herpesvirus 8 sequences in cutaneous cherry angiomas

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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