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01-03-2021 | Musculoskeletal

Detection of gadolinium deposition in cortical bone with ultrashort echo time T₁ mapping: an ex vivo study in a rabbit model

Authors: Kaixuan Zhao, Shisi Li, Peiwei Yi, Yihao Guo, Qinqin Yu, Cuiling Zhu, Qianjin Feng, Jiang Du, Xiaodong Zhang, Yanqiu Feng

Published in: European Radiology | Issue 3/2021

Abstract

Objectives

To investigate the capacity of ultrashort echo time (UTE) T₁ mapping to non-invasively assess gadolinium deposition in cortical bone after gadolinium-based contrast agent (GBCA) administration.

Methods

Twenty-eight New Zealand rabbits (male, 3.0–3.5 kg) were randomly allocated into control, macrocyclic, high-dose macrocyclic, and linear GBCA groups (n = 7 for each group), and respectively given daily doses of 0.9 ml/kg bodyweight saline, 0.3 mmol/kg bodyweight gadobutrol, 0.9 mmol/kg bodyweight gadobutrol, and 0.3 mmol/kg bodyweight gadopentetate dimeglumine for five consecutive days per week over a period of 4 weeks. After a subsequent 4 weeks of recovery, the rabbits were sacrificed and their tibiae harvested. T₁ value of cortical bone was measured using a combination of UTE actual flip angle imaging and variable repetition time on a 7T animal scanner. Gadolinium concentration in cortical bone was measured using inductively coupled plasma mass spectrometry (ICP-MS). Pearson’s correlation between R₁ value (R₁ = 1/T₁) and gadolinium concentration in cortical bone was assessed.

Results

Bone T₁ values were significantly lower in the lower-dose macrocyclic (329.2 ± 21.0 ms, p < 0.05), higher-dose macrocyclic (316.8 ± 21.7 ms, p < 0.01), and linear (296.8 ± 24.1 ms, p < 0.001) GBCA groups compared with the control group (356.3 ± 19.4 ms). Gadolinium concentrations measured by ICP-MS in the control, lower-dose macrocyclic, higher-dose macrocyclic, and linear GBCA groups were 0.04 ± 0.02 μg/g, 2.60 ± 0.48 μg/g, 4.95 ± 1.17 μg/g, and 13.62 ± 1.55 μg/g, respectively. There was a strong positive correlation between R₁ values and gadolinium concentrations in cortical bone (r = 0.73, p < 0.001).

Conclusions

These results suggest that UTE T₁ mapping has the potential to provide a non-invasive assessment of gadolinium deposition in cortical bone following GBCA administration.

Key Points

• Changes in T ₁ value related to gadolinium deposition were found in bone after both linear and macrocyclic GBCA administrations.

• R ₁ relaxometry correlates strongly with gadolinium concentration in cortical bone.

• UTE T ₁ mapping provides a potential tool for non-invasively monitoring gadolinium deposition in cortical bone.

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Title: Detection of gadolinium deposition in cortical bone with ultrashort echo time T1 mapping: an ex vivo study in a rabbit model
Authors: Kaixuan Zhao
Shisi Li
Peiwei Yi
Yihao Guo
Qinqin Yu
Cuiling Zhu
Qianjin Feng
Jiang Du
Xiaodong Zhang
Yanqiu Feng
Publication date: 01-03-2021
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 3/2021
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-020-07258-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Detection of gadolinium deposition in cortical bone with ultrashort echo time T₁ mapping: an ex vivo study in a rabbit model

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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