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European Radiology
Published in: European Radiology 1/2017

01-01-2017 | Magnetic Resonance

Detection of Functional Homotopy in Traumatic Axonal Injury

Authors: Jian Li, Lei Gao, Kai Xie, Jie Zhan, Xiaoping Luo, Huifang Wang, Huifang Zhang, Jing Zhao, Fuqing Zhou, Xianjun Zeng, Laichang He, Yulin He, Honghan Gong

Published in: European Radiology | Issue 1/2017

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Abstract

Objective

This study aimed to explore the interhemispheric intrinsic connectivity in traumatic axonal injury (TAI) patients.

Methods

Twenty-one patients with TAI (14 males, seven females; mean age, 38.71 ± 15.25 years) and 22 well-matched healthy controls (16 males, six females; mean age, 38.50 ± 13.82 years) were recruited, and from them we obtained resting-state fMRI data. Interhemispheric coordination was examined using voxel-mirrored homotopic connectivity (VMHC) and seed-based functional connectivity analysis was performed.

Results

We observed significantly decreased VMHC in a number of regions in TAI patients, including the prefrontal, temporal, occipital, parietal, and posterior cingulate cortices, thalami and cerebellar posterior lobes. Subsequent seed-based functional connectivity analysis revealed widely disrupted functional connectivity between the regions of local homotopic connectivity deficits and other areas of the brain, particularly the areas subserving the default, salience, integrative, and executive systems. The lower VMHC of the inferior frontal gyrus and basal ganglia, thalamus, and caudate were significant correlated with the Beck Depression Inventory score, Clinical Dementia Rating score, and Mini-Mental State Examination score, respectively.

Conclusion

TAI is associated with regionally decreased interhemispheric interactions and extensively disrupted seed-based functional connectivity, generating further evidence of diffuse disconnection being associated with clinical symptoms in TAI patients.

Key Points

• Traumatic axonal injury is associated with decreased interhemispheric connectivity
• Traumatic axonal injury couples with widely disrupted functional connectivity
• These alterations support the default, salience, integrative, and executive functions
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Metadata
Title
Detection of Functional Homotopy in Traumatic Axonal Injury
Authors
Jian Li
Lei Gao
Kai Xie
Jie Zhan
Xiaoping Luo
Huifang Wang
Huifang Zhang
Jing Zhao
Fuqing Zhou
Xianjun Zeng
Laichang He
Yulin He
Honghan Gong
Publication date
01-01-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 1/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4302-x

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