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01-07-2008 | Original Paper

Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy

Authors: Emilie A. Steffen-Smith, Pamela L. Wolters, Paul S. Albert, Eva H. Baker, Kim C. Shimoda, Alan S. Barnett, Katherine E. Warren

Published in: Child's Nervous System | Issue 7/2008

Abstract

Objective

The study objective was to detect abnormalities and identify relationships between brain metabolic ratios determined by proton magnetic resonance spectroscopic imaging (¹H-MRSI) and neuropsychological (NP) function in cancer patients at risk for neurotoxicity.

Methods

Thirty-two patients received ¹H-MRSI using a multi-slice, multi-voxel technique on a 1.5T magnet. Cho/NAA, NAA/Cr, and Cho/Cr ratios were identified in seven pre-determined sites without tumor involvement. A battery of age-appropriate NP tests was administered within 7 days of imaging. Relationships were examined between test scores and metabolite ratios.

Conclusions

This study identifies relationships between brain metabolite ratios and cognitive functioning in cancer patients. ¹H-MRSI may be useful in early detection of neurotoxic effects, but prospective longitudinal studies in a homogeneous population are recommended to determine the prognostic value.

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Title: Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy
Authors: Emilie A. Steffen-Smith
Pamela L. Wolters
Paul S. Albert
Eva H. Baker
Kim C. Shimoda
Alan S. Barnett
Katherine E. Warren
Publication date: 01-07-2008
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 7/2008
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-007-0576-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy

Abstract

Objective

Methods

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Conclusions

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