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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2017

Open Access 01-12-2017 | Research article

Depression and anxiety behaviour in a rat model of chronic migraine

Authors: Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong, Shengyuan Yu

Published in: The Journal of Headache and Pain | Issue 1/2017

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Abstract

Background

Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals.

Methods

A classical chronic migraine rat model (repeated dura mater inflammatory soup [IS] infusion) was used to evaluate depression and anxiety behaviour via weight, sucrose preference test, open field test and elevated plus maze test.

Results

We found that sucrose preference, locomotor and rearing behaviours, inner zoon distance percent, open-arm entries percent and serotonin and dopamine levels in the prefrontal cortex decreased significantly in the IS group compared with those in the control group; co-administration of low-dose amitriptyline ameliorated these deficits. However, no differences in weight, inner zone time percent, or open-arm time percent between the IS and control groups. These results were used to create new depression and anxiety scales to comprehensively assess and evaluate the degree of affective disorders in rats. Most of chronic migraine animals showed depression and anxiety like behaviors but a few didn’t.

Conclusions

Most of the chronic migraine rats were present depression and anxiety like behaviors. The new scales we created are expected to use in the future studies to find out the potential mechanism of affective disorders’ comorbidity.
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Metadata
Title
Depression and anxiety behaviour in a rat model of chronic migraine
Authors
Mingjie Zhang
Yufei Liu
Mangsuo Zhao
Wenjing Tang
Xiaolin Wang
Zhao Dong
Shengyuan Yu
Publication date
01-12-2017
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2017
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-017-0736-z

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