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01-06-2018 | Gastrointestinal

Demystifying liver iron concentration measurements with MRI

Author: B. Henninger

Published in: European Radiology | Issue 6/2018

Abstract

This Editorial comment refers to the article: Non-invasive measurement of liver iron concentration using 3-Tesla magnetic resonance imaging: validation against biopsy. D’Assignies G, et al. Eur Radiol Nov 2017.

Key Points

• MRI is a widely accepted reliable tool to determine liver iron concentration.

• MRI cannot measure iron directly, it needs calibration.

• Calibration curves for 3.0T are rare in the literature.

• The study by d’Assignies et al. provides valuable information on this topic.

• Evaluation of liver iron overload should no longer be restricted to experts.

Alustiza Echeverria JM, Castiella A, Emparanza JI (2012) Quantification of iron concentration in the liver by MRI. Insights Imaging 3:173–180CrossRefPubMed

Gandon Y, Olivie D, Guyader D et al (2004) Non-invasive assessment of hepatic iron stores by MRI. Lancet 363:357–362CrossRefPubMed

Henninger B, Zoller H, Rauch S et al (2015) R2* relaxometry for the quantification of hepatic iron overload: biopsy-based calibration and comparison with the literature. Rofo 187:472–479CrossRefPubMed

Hankins JS, McCarville MB, Loeffler RB et al (2009) R2* magnetic resonance imaging of the liver in patients with iron overload. Blood 113:4853–4855CrossRefPubMedPubMedCentral

Wood JC, Enriquez C, Ghugre N et al (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106:1460–1465CrossRefPubMedPubMedCentral

Garbowski MW, Carpenter JP, Smith G et al (2014) Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan. J Cardiovasc Magn Reson 10:16–40

Henninger B, Kremser C, Rauch S et al (2012) Evaluation of MR imaging with T1 and T2* mapping for the determination of hepatic iron overload. Eur Radiol. 22:2478–2486CrossRefPubMed

Storey P, Thompson AA, Carqueville CL, Wood JC, de Freitas RA, Rigsby CK (2007) R2* imaging of transfusional iron burden at 3T and comparison with 1.5T. J Magn Reson Imaging 25:540–547CrossRefPubMedPubMedCentral

Wood JC (2014) Guidelines for quantifying iron overload. Hematology Am Soc Hematol Educ Program 2014:210–215PubMed

10.

Paisant A, Boulic A, Bardou-Jacquet E et al (2017) Assessment of liver iron overload by 3 T MRI. Abdom Radiol (NY) 42:1713–1720CrossRef

Title: Demystifying liver iron concentration measurements with MRI
Author: B. Henninger
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 6/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5199-8

At a glance: The STEP trials

Springer Medicine

Demystifying liver iron concentration measurements with MRI

Abstract

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Key Points

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