Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 9/2014

01-09-2014 | Musculoskeletal

Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC

Authors: Jasper van Tiel, Gyula Kotek, Max Reijman, Pieter K. Bos, Esther E. Bron, Stefan Klein, Jan A. N. Verhaar, Gabriel P. Krestin, Harrie Weinans, Edwin H. G. Oei

Published in: European Radiology | Issue 9/2014

Login to get access

Abstract

Objectives

To assess (1) whether normal and degenerated menisci exhibit different T1GD on delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM), (2) the reproducibility of dGEMRIM and (3) the correlation between meniscus and cartilage T1GD in knee osteoarthritis (OA) patients.

Methods

In 17 OA patients who underwent dGEMRIM twice within 7 days, meniscus and cartilage T1GD was calculated. Meniscus pathology was evaluated on conventional MRI. T1GD in normal and degenerated menisci were compared using a Student’s t-test. Reproducibility was assessed using ICCs. Pearson’s correlation was calculated between meniscus and cartilage T1GD.

Results

A trend towards lower T1GD in degenerated menisci (mean: 402 ms; 95 % CI: 359–444 ms) compared to normal menisci (mean: 448 ms; 95 % CI: 423–473 ms) was observed (p = 0.05). Meniscus T1GD ICCs were 0.85–0.90. The correlation between meniscus and cartilage T1GD was moderate in the lateral (r = 0.52–0.75) and strong in the medial compartment (r = 0.78–0.94).

Conclusions

Our results show that degenerated menisci have a clear trend towards lower T1GD compared to normal menisci. Since these results are highly reproducible, meniscus degeneration may be assessed within one delayed gadolinium-enhanced MRI simultaneously with cartilage. The strong correlation between meniscus and cartilage T1GD suggests concomitant degeneration in both tissues in OA, but also suggests that dGEMRIC may not be regarded entirely as sulphated glycosaminoglycan specific.

Key Points

• dGEMRIM T1 GD can possibly be used to assess meniscal degeneration;
• dGEMRIM yields highly reproducible meniscal T1 GD in early stage osteoarthritic patients;
• Concomitant degeneration of cartilage and meniscus tissue occurs in early stage osteoarthritis;
• dGEMRIC cannot be regarded as entirely sulphated glycosaminoglycan specific.
Literature
1.
2.
3.
4.
Yelin E, Murphy L, Cisternas MG, Foreman AJ, Pasta DJ, Helmick CG (2007) Medical care expenditures and earnings losses among persons with arthritis and other rheumatic conditions in 2003, and comparisons with 1997. Arthritis Rheum 56:1397–1407PubMedCentralPubMedCrossRef
5.
6.
Hunter DJ, Zhang YQ, Niu JB et al (2006) The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis. Arthritis Rheum 54:795–801PubMedCrossRef
7.
Englund M, Guermazi A, Roemer FW et al (2009) Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons. The Multicenter Osteoarthritis Study. Arthritis Rheum 60:831–839PubMedCentralPubMedCrossRef
8.
Englund M, Guermazi A, Lohmander SL (2009) The role of the meniscus in knee osteoarthritis: a cause or consequence? Radiol Clin N Am 47:703–712PubMedCrossRef
9.
Buckwalter JA, Mankin HJ (1998) Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 47–1998:487–504
10.
Grushko G, Schneiderman R, Maroudas A (1989) Some biochemical and biophysical parameters for the study of the pathogenesis of osteoarthritis: a comparison between the processes of ageing and degeneration in human hip cartilage. Connect Tissue Res 19:149–176PubMedCrossRef
11.
Mcnicol D, Roughley PJ (1980) Extraction and characterization of proteoglycan from human meniscus. Biochem J 185:705–713PubMedCentralPubMed
12.
Bashir A, Gray ML, Boutin RD, Burstein D (1997) Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology 205:551–558PubMedCrossRef
13.
Tiderius CJ, Olsson LE, Leander P, Ekberg O, Dahlberg L (2003) Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis. Magn Reson Med 49:488–492PubMedCrossRef
14.
Bashir A, Gray ML, Hartke J, Burstein D (1999) Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med 41:857–865PubMedCrossRef
15.
Hellio Le Graverand MP, Vignon E, Otterness IG, Hart DA (2001) Early changes in lapine menisci during osteoarthritis development: part I: cellular and matrix alterations. Osteoarthr Cartil 9:56–64PubMedCrossRef
16.
Krishnan N, Shetty SK, Williams A, Mikulis B, McKenzie C, Burstein D (2007) Delayed gadolinium-enhanced magnetic resonance imaging of the meniscus: an index of meniscal tissue degeneration? Arthritis Rheum 56:1507–1511PubMedCrossRef
17.
Mayerhoefer ME, Mamisch TC, Riegler G et al (2011) Gadolinium diethylenetriaminepentaacetate enhancement kinetics in the menisci of asymptomatic subjects: a first step towards a dedicated dGEMRIC (delayed gadolinium-enhanced MRI of cartilage)-like protocol for biochemical imaging of the menisci. NMR Biomed 24:1210–1215PubMedCrossRef
18.
Venn M, Maroudas A (1977) Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition. Ann Rheum Dis 36:121–129PubMedCentralPubMedCrossRef
19.
20.
Jensen MP, Miller L, Fisher LD (1998) Assessment of pain during medical procedures: a comparison of three scales. Clin J Pain 14:343–349PubMedCrossRef
21.
22.
McKenzie CA, Williams A, Prasad PV, Burstein D (2006) Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. J Magn Reson Imaging 24:928–933PubMed
23.
Studler U, White LM, Andreisek G, Luu S, Cheng HLM, Sussman MS (2010) Impact of motion on T1 mapping acquired with inversion recovery fast spin echo and rapid spoiled gradient recalled-echo pulse sequences for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in volunteers. J Magn Reson Imaging 32:394–398PubMed
24.
Bron EE, van Tiel J, Smit H et al (2013) Image registration improves human knee cartilage T1 mapping with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Eur Radiol 23:246–252PubMedCentralPubMedCrossRef
25.
van Tiel J, Bron EE, Tiderius CJ et al (2013) Reproducibility of 3D delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the knee at 3.0T in patients with early stage osteoarthritis. Eur Radiol 23:496–504PubMedCrossRef
26.
van Tiel J, Reijman M, Bos PK et al (2013) Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) shows no change in cartilage structural composition after viscosupplementation in patients with early-stage knee osteoarthritis. PLoS One 8:e79785PubMedCentralPubMedCrossRef
27.
Tiderius C, Hori M, Williams A et al (2006) dGEMRIC as a function of BMI. Osteoarthr Cartil 14:1091–1097PubMedCrossRef
28.
Crues JV, Mink J, Levy TL, Lotysch M, Stoller DW (1987) Meniscal tears of the knee—accuracy of MR imaging. Radiology 164:445–448PubMedCrossRef
29.
Reicher MA, Hartzman S, Duckwiler GR, Bassett LW, Anderson LJ, Gold RH (1986) Meniscal injuries—detection using MR imaging. Radiology 159:753–757PubMedCrossRef
30.
Atkinson G, Nevill AM (1998) Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. Sports Med 26:217–238PubMedCrossRef
31.
Meredith DS, Losina E, Mahorned NN, Wright J, Katz JN (2005) Factors predicting functional and radiographic outcomes after arthroscopic partial meniscectomy: a review of the literature. Arthrosc J Arthrosc Relat Surg 21:211–223CrossRef
32.
Salata MJ, Gibbs AE, Sekiya JK (2010) A systematic review of clinical outcomes in patients undergoing meniscectomy. Am J Sports Med 38:1907–1916PubMedCrossRef
33.
Duvvuri U, Kudchodkar S, Reddy R, Leigh JS (2002) T(1rho) relaxation can assess longitudinal proteoglycan loss from articular cartilage in vitro. Osteoarthr Cartil 10:838–844PubMedCrossRef
34.
Nieminen MT, Rieppo J, Toyras J et al (2001) T2 relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study. Magn Reson Med 46:487–493PubMedCrossRef
35.
Zarins ZA, Bolbos RI, Pialat JB et al (2010) Cartilage and meniscus assessment using T1rho and T2 measurements in healthy subjects and patients with osteoarthritis. Osteoarthr Cartil 18:1408–1416PubMedCentralPubMedCrossRef
36.
Li W, Edelman RR, Prasad PV (2011) Delayed contrast enhanced MRI of meniscus with ionic and non-ionic agents. J Magn Reson Imaging 33:731–735PubMed
37.
Li W, Scheidegger R, Wu Y et al (2010) Delayed contrast-enhanced MRI of cartilage: comparison of nonionic and ionic contrast agents. Magn Reson Med 64:1267–1273PubMedCrossRef
38.
Silvast TS, Jurvelin JS, Tiitu V, Quinn TM, Töyräs J (2013) Bath concentration of anionic contrast agents does not affect their diffusion and distribution in articular cartilage in vitro. Cartilage 4:42–51CrossRef
39.
Wiener E, Settles M, Weirich G, Schmidt C, Diederichs G (2011) The influence of collagen network integrity on the accumulation of gadolinium-based MR contrast agents in articular cartilage. 183:226–232. doi:10.​1055/​s-0029-1245739
40.
Salo EN, Nissi MJ, Kulmala KA, Tiitu V, Toyras J, Nieminen MT (2012) Diffusion of Gd-DTPA(2)(-) into articular cartilage. Osteoarthr Cartil 20:117–126PubMedCrossRef
41.
Siebelt M, van Tiel J, Waarsing JH et al (2011) Clinically applied CT arthrography to measure the sulphated glycosaminoglycan content of cartilage. Osteoarthr Cartil 19:1183–1189PubMedCrossRef
42.
Watanabe A, Wada Y, Obata T et al (2006) Delayed gadolinium-enhanced MR to determine glycosaminoglycan concentration in reparative cartilage after autologous chondrocyte implantation: preliminary results. Radiology 239:201–208PubMedCrossRef
43.
Son M, Goodman SB, Chen W, Hargreaves BA, Gold GE, Levenston ME (2013) Regional variation in T1rho and T2 times in osteoarthritic human menisci: correlation with mechanical properties and matrix composition. Osteoarthr Cartil 21:796–805PubMedCentralPubMedCrossRef
44.
Williams A, Qian Y, Golla S, Chu CR (2012) UTE-T2* mapping detects sub-clinical meniscus injury after anterior cruciate ligament tear. Osteoarthr Cartil 20:486–494PubMedCrossRef
Metadata
Title
Delayed gadolinium-enhanced MRI of the meniscus (dGEMRIM) in patients with knee osteoarthritis: relation with meniscal degeneration on conventional MRI, reproducibility, and correlation with dGEMRIC
Authors
Jasper van Tiel
Gyula Kotek
Max Reijman
Pieter K. Bos
Esther E. Bron
Stefan Klein
Jan A. N. Verhaar
Gabriel P. Krestin
Harrie Weinans
Edwin H. G. Oei
Publication date
01-09-2014
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 9/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3204-z

Other articles of this Issue 9/2014

European Radiology 9/2014 Go to the issue

Hepatobiliary-Pancreas

Spectral CT evaluation of interstitial brachytherapy in pancreatic carcinoma xenografts: preliminary animal experience

Ultrasound

US-guided high-intensity focused ultrasound as a promising non-invasive method for treatment of primary hyperparathyroidism

Urogenital

T1-mapping for assessment of ischemia-induced acute kidney injury and prediction of chronic kidney disease in mice

Computed Tomography

Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method

Oncology

Diffusion-weighted MR imaging for differentiating borderline from malignant epithelial tumours of the ovary: pathological correlation

Magnetic Resonance

MRI-based Determination of Reference Values of Thoracic Aortic Wall Thickness in a General Population